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BMN 673

BMN 673 Structure
CAS No.
1207456-01-6
Chemical Name:
BMN 673
Synonyms
LT-673;CS-750;BMN 673;MDV3800);Talazoparib;BMN 673, >=98%;(8S,9R)-BMN 673;BMN 673 USP/EP/BP;BMN-673, TALAZOPARIB;Talazoparib (BMN 673)
CBNumber:
CB22615112
Molecular Formula:
C19H14F2N6O
Molecular Weight:
380.35
MOL File:
1207456-01-6.mol
Modify Date:
2024/1/3 15:56:48
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BMN 673 Properties

Melting point 247 - 249°C
Density 1.63
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 10.14±0.60(Predicted)
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360-H372-H341
Precautionary statements  P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501

BMN 673 Chemical Properties,Uses,Production

Enzyme inhibitor

This novel, orally bioavailable poly(ADP-ribose) polymerase, or PARP, inhibitor (FW = 380.35 g/mol; CAS 1207456-01-6), also known as (8S,9R)- 5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro- 2H-pyrido[4,3,2-de]phthalazin-3(7H)-one, targets PARP-mediated DNA repair (IC50 = 0.58 nM) of single-strand DNA breaks by the base-excision repair pathway. By enhancing the accumulation of DNA strand breaks, BMN 673 promotes genomic instability, eventually leading to apoptosis. BMN 673 exhibits selective anti-tumor cytotoxicity and elicits DNA repair biomarkers at much lower concentrations than earlier generation PARP1/2 inhibitors, including olaparib, rucaparib and veliparib. BMN 673 shows remarkable anti-tumor activity in vivo, with strong action against xenografted tumors carrying defects in DNA repair due to BRCA mutations or PTEN deficiency. Synergistic or additive anti-tumor effects are observed, when BMN 673 was combined with temozolomide, SN38 or platinum drugs.

BMN 673 Preparation Products And Raw materials

Raw materials

LT-673 Benzoic acid, 5-fluoro-2-[2-(1-Methyl-1H-1,2,4-triazol-5-yl)acetyl]-3-nitro-, Methyl ester 1(2H)-Phthalazinone, 7-fluoro-5-[(E)-[(4-fluorophenyl)methylene]amino]-4-[(1-methyl-1H-1,2,4-triazol-5-yl)methyl]- 5-Quinolinecarboxylic acid, 7-fluoro-2-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-hydroxy-3-(1-methyl-1H-1,2,4-triazol-5-yl)-4-oxo-, methyl ester 5-Quinolinecarboxylic acid,7-fluoro-2-(4-fluorophenyl)-1,2,3,4-tetrahydro-3-(1-Methyl-1H-1,2,4-triazol-5-yl)-4-oxo-,Methyl ester,(2S,3S)-
1(3H)-Isobenzofuranone,6-fluoro-3-[(1-Methyl-1H-1,2,4-triazol-5-yl)Methylene]-4-nitro-,(3Z)- BMN 673 (8R,9S) 6-Fluoro-4-nitro-3H-isobenzofuran-1-one 5-Quinolinecarboxylic acid, 7-fluoro-2-(4-fluorophenyl)-1,2,3,4-tetrahydro-3-(1-Methyl-1H-1,2,4-triazol-5-yl)-4-oxo-, Methyl ester
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Preparation Products

BMN 673 Suppliers

Global( 184)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29898 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Baoji Guokang Bio-Technology Co., Ltd. 0917-3909592 13892490616 China 9322 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
SynZeal Research Pvt Ltd 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
Dideu Industries Group Limited 58
Baoji Guokang Bio-Technology Co., Ltd. 58

Related articles

BMN 673 Spectrum

BMN 673(1207456-01-6)MS

1207456-01-6(BMN 673)Related Search:

LOXO-101 (sulfate) LOXO-101 Bortezomib PF-01367338 Selumetinib
MG-132 Veliparib Olaparib
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BMN 673 LT-673 (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-Methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one Talazoparib 3H-Pyrido[4,3,2-de]phthalazin-3-one, 5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-, (8S,9R)- Talazoparib (BMN 673) (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazine-3-one BMN673 BMN 673, >=98% (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4 BMN 673 USP/EP/BP LT-673;BMN673;LT673;TALAZOPARIB; BMN 673 Talazoparib - BMN 673 | LT 00673 CS-750 LT-673;BMN673;LT673;BMN-673;BMN 673 (8S,9R)-BMN 673 BMN-673, TALAZOPARIB (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)- 2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one MDV3800) (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-... inhibit,LT673,BRCA1/2,MX-1,PARP-mediated,Talazoparib,poly ADP ribose polymerase,BMN 673,breast cancer,BMN673,Inhibitor,PARylation,anticancer,LT 673,PARP BMN-673 (TALAZOPARIB) (MDV-3800) (LT 00673) Brotizolam Impurity 4 1207456-01-6 C19H14F2N6O Inhibitors API