BMN 673
BMN 673
- CAS:
- 1207456-01-6
- MF:
- C19H14F2N6O
- MW:
- 380.35
Suppliers by country/region
Company Type
Properties
- Melting point:
- 247 - 249°C
- Density
- 1.63
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.14±0.60(Predicted)
- color
- White to Off-White
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Danger
- Hazard statements
- H360-H372-H341
- Precautionary statements
- P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501
Use
BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. BMN 673 selectively kills cancer cells with BRCA-1 or BRCA-2 mutations. BMN 673 demonstrates single-agent cytotoxicityin BRCA-1 mutant (MX-1, IC50 = 0.3 nM) and BRCA-2 mutant cells (Capan-1, IC50 = 5 nM). In contrast, in MRC-5 normal human fibroblastand other tumor cell lines with wild-type BRCA-1 and BRCA-2 genes, IC50 of BMN 673 ranges between 90 nM and 1.9 μM. In cultured human cancer cells, BMN 673 also significantly enhances the cytotoxic efficacy of both Temozolomide and SN-38. Off-target molecular screening did not identify significant non-specific activity for this class of PARP inhibitors.
0 India supplier list of "BMN 673"
![](/images/pro-3.jpg)
- Product Name:Talazoparib
- Products Intro:Brand:synzeal | Product Number:326147159
- Company Type: Trader
- Country/Region: INDIA
![](/images/pro-3.jpg)
- Product Name:BMN 673
- Products Intro:Purity: 98% | Package: 25KG
- Company Type: Trader
- Country/Region: CHINA