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KAINIC ACID

KAINIC ACID Structure
CAS No.
487-79-6
Chemical Name:
KAINIC ACID
Synonyms
KAINATE;(-)-α-Kainic Acid;C12819;Kainic;digenin;helminal;(3aαKainicaci;,4-beta))-;KAINIC ACID
CBNumber:
CB2351306
Molecular Formula:
C10H15NO4
Molecular Weight:
213.23
MOL File:
487-79-6.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
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KAINIC ACID Properties

Melting point 253-254 C
alpha D24 -14.8° (c = 1.01)
Boiling point 353.22°C (rough estimate)
Density 1.2177 (rough estimate)
refractive index 1.4368 (estimate)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility H2O: soluble
form White to off-white solid.
pka 2.03±0.60(Predicted)
color White
optical activity -14.824 (H2O)
Water Solubility Soluble to 25 mM in water
Stability Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
InChIKey VLSMHEGGTFMBBZ-OOZYFLPDSA-N
SMILES N1C[C@H](C(C)=C)[C@H](CC(O)=O)[C@H]1C(O)=O
EPA Substance Registry System 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)- (487-79-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  22-24/25-36
WGK Germany  3

KAINIC ACID Chemical Properties,Uses,Production

Chemical Properties

soluble in 0.1 M NaOH

Uses

(-)-α-Kainic Acid is a naturally occurring neuroexcitatory chemical that is an selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.

Biological Activity

Selective agonist at kainate receptors. Potent excitant and neurotoxin. Also available as part of the Kainate Receptor Tocriset™ .

Purification Methods

Purify the acid by adsorbing on to a strongly acidic ion-exchange resin (Merck), elute the diacid with aqueous M NaOH, the eluate is evaporated, H2O is added, and filtered through a weakly acidic ion-exchange resin (Merck). The filtrate is then evaporated and recrystallised from EtOH. Its solubility is 0.1g in 1mL of 0.5N HCl. (±)--Kainic acid is recrystallised from H2O with m 230-260o. UV (MeOH): 219 (log 3.9); max 1HNMR (CCl4, 100MHz, Me4Si standard) : 1.64 (s 1H), 1.70 (s 3H), 3.24 (d J 7.5, 2H), 3.3-4.2 (1H), 3.70 (s 3H), 3.83 (s 3H), 4.35 (dd J 7.5, J 14.5, 1H), 5.21 (t J 7.5, 1H), 7.26 (t J 7.5, 1H). [Oppolzer & Andres Helv Chim Acta 62 2282 1979, Beilstein 22 III/IV 1523.]

KAINIC ACID Preparation Products And Raw materials

Raw materials

3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethenyl)-1-[(4-methylphenyl)sulfonyl]-, (2S,3S,4S)-

Preparation Products

KAINIC ACID Suppliers

Global( 150)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Finetech Industry Limited +86-27-8746-5837 +8619945049750 China 9642 58 Inquiry
Alfa Chemistry United States 24072 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49734 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3135 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 49984 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43340 58 Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd. +86-18621343501; +undefined18621343501 China 33338 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
TargetMol Chemicals Inc. 58
Finetech Industry Limited 58
Alfa Chemistry 58
InvivoChem 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
Nantong HI-FUTURE Biology Co., Ltd. 58
GIHI CHEMICALS CO.,LIMITED 58
LEAPCHEM CO., LTD. 58
Shanghai Acmec Biochemical Technology Co., Ltd. 58

KAINIC ACID Spectrum

KAINIC ACID(487-79-6)MSKAINIC ACID(487-79-6)IR1KAINIC ACID(487-79-6)IR2

487-79-6(KAINIC ACID)Related Search:

DOMOIC ACID KAINIC ACID KAINIC ACID 2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE rac-Kainic Acid KAINIC ACID DIMETHYL ESTER HYDROCHLORIDE
seco-Kainic acid KAINIC ACID, [VINYLIDENE-3H] acromelic acid A KAINIC ACID, G-(A-CARBOXY-2-NITROBENZYL)ESTER Kainic Acid Rabbit Polyclonal
Receptors, Kainic Acid (-)-KAINIC ACID MONOHYDRAT KAINIC ACID (OPIKA-1?) KAINIC ACID, G-(A-CARBOXY-2-NITROBENZYL)ESTER HYDROCHLORIDE KAINIC ACID METHYL ESTER
(-)-(ALPHA)-KAINIC ACID HYDRATE Kainic Acid, Natural KAINIC ACID DIMETHYL ESTER
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(-)-A-KAINIC ACID KAINIC ACID KAINIC ACID SYNTHETIC KAINIC ACID (OPIKA-1(TM)) Kainic C12819 (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineaceticacid 3-(carboxyMethyl)-4-prop-1-en-2-ylproline (2S,3S,4S)-2-Carboxy-4-isopropenylpyrrolidine-3-acetic acid L-alpha-Kainic acid 3-Pyrrolidineaceticacid, 2-carboxy-4-(1-methylethenyl)-, (2S,3S,4S)- ,4-beta))- 2-carboxy-4-isopropenyl-3-pyrrolidineaceticaci 3-pyrrolidineaceticacid,2-carboxy-4-(1-methylethenyl)-,(2s-(2-alpha,3-beta alpha-kainicacid digenicacid digenin helminal (2-CARBOXY-3-CARBOXYMETHYL-4-ISOPROPENYLPYRROLIDINE) 2-CARBOXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID 2-CARBOXYL-3-CARBOXYMETHYL-4-ISOPROPENYL PYRROLIDINE [2S-(2A,3B,4B)]-2-CARBOXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID (2S,3S,4R)-CARBOXY-4-(1-METHYLETHENYL)-3-PYRROLIDINEACETIC ACID -Dihydroxyandrost-5-en-17-one 12-dihydroxyguaian-6,10-diene )]-Hexahydro-2-oxo-1,3-bis(phenylmethyl)-1H-Thieno[3,4-d]imidazole-4-pentanoic Acid Phenylmethyl Ester [3aS-(3a&alpha (3a&alpha )-3a,4,7,7a-Tetrahydro-4-hydroxy-1H-isoindole-1,3(2H)-dione 7-p-Toluenesulfonylhydrazide 3&beta -Dihydroxy-chol-5-ene-24-carboxylic Acid Ethyl Ester -glucopyranosyl-(1&rarr Periplogenin 3-[O-&beta -sarmentopyranoside] -Hydroxy Cholesterol-d4 (Major) [2S-[1(S*),2&alpha ]]-4-Methyl-1-(1-phenylethyl)-2-piperidinecarboxylic Acid Ethyl Ester )-7-Dehydro-4,25-dihydroxycholesterol -Hydroxy Cholesterol 4-Acetate )-3,4-Dihydroxy-chol-5,7-diene-24-carboxylic Acid Methyl Ester -Allopyranosyl-(1&rarr -oleandropyranosyl-11-O-isobutyryl-12-O-acetyl- Tenacigenin B, 3-O-&beta )]-4-[2-(2,5-Dihydroxyphenyl)ethyl]octahydro-1-hydroxy-7a-methyl-5H-inden-5-one (2S,3S,4S)-3-(carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid -Hydroxy Cholesterol-d7 4-Acetate -Diacetyloxy-chol-5-ene-24-carboxylic Acid Ethyl Ester )-4,5-Epoxy-13-ethyl-17-hydroxy-18,19-dinorpregn-20-yn-3-one Kainicaci KAINATE (-)-α-Kainic Acid α-Kainic acid Kainic acid (mM/ml), Prototypic kainate receptor agonist Kainic acid, prototypic kainate receptor agonist Kainic acid, 10 mM in DMSO 487-79-6 Glutamate receptor