DOMOIC ACID

CAS No.: 14277-97-5

Chemical Name:: DOMOIC ACID

Synonyms: C13732;Domoic;omoicaci;NSC 288031;DOMOIC ACID;L-Domic acid;(-)-Domic acid;DoMoic Acid-d3;(-)-DoMoic Acid-d3;Domoic acid, 100ppm

CBNumber:: CB2359498

Molecular Formula:: C15H21NO6

Molecular Weight:: 311.33

MOL File:: 14277-97-5.mol

Modify Date:: 2023/4/23 13:52:06

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DOMOIC ACID Properties

Melting point	213-217℃
Boiling point	451.38°C (rough estimate)
Density	1.1800 (rough estimate)
refractive index	1.5130 (estimate)
storage temp.	-20°C
solubility	methanol: 0.6 mg/mL
form	solid
pka	2.08±0.60(Predicted)
color	white
Water Solubility	Soluble in water at 8mg/ml. Soluble in methanol at 0.6mg/ml.
Merck	13,3451
BRN	46376
Stability	Light Sensitive
EPA Substance Registry System	Domoic acid (14277-97-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H302-H370
Precautionary statements	P260-P264-P270-P301+P312-P308+P311-P405
Hazard Codes	Xn
Risk Statements	20/21/22
Safety Statements	36/37
WGK Germany	3
RTECS	UX9665100
Toxicity	An excitory amino acid isolated from the red alga Chondria armata. A structural analog of kainic acid and domoic acid has been shown to be responsible for the shellfish poisoning associated with eating certain cultured blue mussels.

DOMOIC ACID Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Labelled Domoic Acid. Domoic Acid is an excitatory amino acid isolated from the red alga Chondria armata Okamura, Rhodomelaceae. Domoic acid shown to be responsible for amnesic shellfish poisoning ass ociated with ingestion of certain cultured blue mussels. Domoic Acid is a structural analog of Kainic acid (K135000).

Definition

ChEBI: A L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is an analog of kainic acid and is the neurotoxin associated with the a nesic shellfish poisoning (ASP).

General Description

Domoic acid, a heterocyclic amino acid neurotoxin is synthesized by various marine algaes. It possess some structural similarity to kainic acid.

Biological Activity

More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.

Purification Methods

Domoic acid (~300 mg) is purifed on a Dowex1 column (3.5 x 40 mm, 200-400 mesh, acetate form), washed with H2O until neutral, then eluted with increasing concentrations of AcOH (8L) from 0 to 0.25M. The fraction containing domoic acid (in 50mL) is collected, evaporated to dryness under reduced pressure and recrystallised from aqueous EtOH. It is a glutamate and a Kainate receptor agonist. [Impellizzeri et al. Phytochemistry 14 1549 1975, Takemoto & Diago Arch Pharm 293 627 1960, Beilstein 22/4 V 371.]

DOMOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

DOMOIC ACID Suppliers

Global( 83)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21669	55	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry
Naturewill Biotechnology Co., Ltd.	18113192475 18113192475	China	4999	58	Inquiry
Shaanxi Xihua Chemical Industry Co., Ltd	029-81122149 13992773979	China	6355	58	Inquiry
Shanghai Easy CDMO Co.,Ltd	021-61734564	China	10010	58	Inquiry
Guangdong Wengjiang Chemical Reagent Co.,Ltd.	0751-2815983 13927872582	China	2529	58	Inquiry
TCI (Shanghai) Chemical Trading Co., Ltd.	021-021-61109150	China	31163	58	Inquiry
cjbscvictory	13348960310 13348960310	China	10000	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Henan Tianfu Chemical Co.,Ltd.	55
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Naturewill Biotechnology Co., Ltd.	58
Shaanxi Xihua Chemical Industry Co., Ltd	58
Shanghai Easy CDMO Co.,Ltd	58
Guangdong Wengjiang Chemical Reagent Co.,Ltd.	58
TCI (Shanghai) Chemical Trading Co., Ltd.	58
cjbscvictory	58

14277-97-5(DOMOIC ACID)Related Search:

Trifluoroacetic acid Thickening agent Pyrrolidine Benzimidazole Methylene Blue trihydrate

MONOCROTALINE PATULIN Acetic acid DEOXYNIVALENOL Zearalenone

TOXIN II, ANEMONIA SULCATA KAINIC ACID (2S,3S)-3-METHYLPYRROLIDINE-2-CARBOXYLIC ACID DOMOIC ACID 3-Pyrrolidineacetic acid

DOMOIC ACID = DOMOINS?URE DOMOIC ACID PRITY: 90% POTEN MUSSEL TISSUE - DOMOIC ACID(CRM STANDARD)

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(2S-(2-alpha,3-beta,4-beta(1Z,3E,5S*)))-2-Carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineacetic acid (-)-Domic acid (2S)-2α-Carboxy-4β-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadienyl]-3β-pyrrolidineacetic acid L-Domic acid 3-Pyrrolidineacetic acid, 2-carboxy-4-(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadienyl- C13732 (2S,3S,4S)-2-Carboxy-4-[(1Z,3E,5R)-5-carboxy-1-Methyl-1,3-hexadien-1-yl]-3-pyrrolidineacetic Acid NSC 288031 (-)-DoMoic Acid-d3 (2S,3S,4S)-2-Carboxy-4-[(1Z,3E,5R)-5-carboxy-1-Methyl-1,3-hexadien-1-yl]-3-pyrrolidineacetic Acid-d3 DoMoic Acid-d3 2-carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-3-pyrrolidineaceticaci(2s DOMOIC ACID DOMOIC ACID, MYTILUS EDULIS 3-beta,4-beta(1z,3e,5s*)))--(2-alph 2S-[2ALPHA, 3BETA, 4BETA (1Z, 3E, 5R)]-2-CARBOXY-4-(5-CARBOXY-1-METHYL-1,3-HEXADIENYL)-3-PYRROLIDINEACETIC ACID (2S,3S,4R,5'R)-2-CARBOXY-4-(5'-CARBOXY-1'-METHYL-1Z,3E-HEXADIENYL)-3-PYRROLIDINEACETIC ACID Domoic 3-Pyrrolidineacetic acid, 2-carboxy-4-(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadienyl-, (2S,3S,4S)- AMNESICSHELLFISHPOISON AMNESICSHELLFISHPOISONING DOMOICACID=DOMOINSRE 14277-97-5 DOMOIC ACID omoicaci Myticus edulis, homogenized (Domoic acid) Domoic acid, 100ppm 3-Pyrrolidineacetic acid, 2-carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadien-1-yl]-, (2S,3S,4S)- Domoic Acid, Mytilus edulis - CAS 14277-97-5 - Calbiochem (2S,3S,4S)-4-[(2Z,4E,6R)-6-carboxyhepta-2,4-dien-2-yl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid Buprenorphine Impurity 23 14277-97-5 Biochemicals and Reagents BioChemical Amino Acids and Peptides A - H Cell Signaling and Neuroscience Cell Biology Ligand-Gated Ion Channels Modified Amino Acids Ion Channels Ionotropic Glutamate Receptor Modulators Amino Acids & Derivatives Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Glutamate receptor AlgaeNeurotransmitters AMPA/Kainate AgonistsIon Channels Ionotropic Glutamate Receptor Modulators Cell Signaling and Neuroscience Excitatory Amino Acids Ligand-Gated Ion Channels Toxins and Venoms