Methylene Blue trihydrate
- CAS No.
- 7220-79-3
- Chemical Name:
- Methylene Blue trihydrate
- Synonyms
- METHYLENE BLUE HYDRATE;Methylene Blue, CP;METHYLTHIONINE CHLORIDE;Methylene Blue trihydratee;Methyltltioninium Chloride;Methylthioninium Chloride Trihydrate;SJ-09;CI 52015;CI NO 52015;ue trihydrate
- CBNumber:
- CB3748860
- Molecular Formula:
- C16H20ClN3OS
- Molecular Weight:
- 337.87
- MOL File:
- 7220-79-3.mol
- Modify Date:
- 2024/8/28 18:16:09
| Melting point | 190 °C (dec.)(lit.) |
|---|---|
| Density | 0.98 g/mL at 25 °C |
| Flash point | 14 °C |
| storage temp. | no restrictions. |
| solubility | Soluble in water, chloroform; sparingly soluble in ethanol |
| Colour Index | 52015 |
| form | Solid |
| pka | 2.6, 11.2(at 25℃) |
| color | Green |
| Water Solubility | 4 g/100 mL |
| λmax | 668 nm, 609 nm |
| Merck | 13,6085 |
| Stability | Stable. Incompatible with bases, reducing agents, strong oxidizing agents. |
| Biological Applications | Diagnosis of tauopathy,Alzheimer’s disease (AD),Pick’s disease; treating prophylaxis; dental materials |
| InChIKey | YAFGUSOAMIMROI-UHFFFAOYSA-M |
| CAS DataBase Reference | 7220-79-3(CAS DataBase Reference) |
| IARC | 3 (Vol. 108) 2016 |
| EPA Substance Registry System | Methylene blue trihydrate (7220-79-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Hazard Codes | Xn,F |
| Risk Statements | 22-36/37/38-11 |
| Safety Statements | 26-36-24/25-16-7 |
| RIDADR | UN 1170 3/PG 2 |
| WGK Germany | 3 |
| RTECS | SP5740000 |
| TSCA | Yes |
| HS Code | 32129000 |
Methylene Blue trihydrate price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1.59270 | Methylene blue (C.I. 52015) Reag. Ph Eur | 7220-79-3 | 10G | ₹3910 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 1.59270 | Methylene blue (C.I. 52015) Reag. Ph Eur | 7220-79-3 | 10G | ₹3910 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 6210-OP | OmniPur® Methylene Blue, Trihydrate | 7220-79-3 | 100G | ₹10840.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 1.59270 | Methylene blue (C.I. 52015) Reag. Ph Eur | 7220-79-3 | 100G | ₹12870.01 | 2022-06-14 | Buy |
| Sigma-Aldrich | 1.15943 | Methylene blue (C.I.52015) for microscopy Certistain? | 7220-79-3 | 25G | ₹9340 | 2022-06-14 | Buy |
Methylene Blue trihydrate Chemical Properties,Uses,Production
Chemical Properties
Methylene Blue trihydrate is a dark green crystalline powder that has a bronze-like luster. When dissolved in water or alcohol, it creates a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It can also inhibit guanylate cyclase and has been used to treat cyanide poisoning and lower levels of methemoglobin.
Uses
Methylene Blue trihydrate finds many uses in biology and chemistry. It acts as a GCS inhibitor, biological stain and redox indicator. It inhibits tau filament formation. Further, it is reported to bind to the M2 subtype of muscarinic receptors in rat cardiac myocytes and thus exhibit antimuscarinic effects on IK, ACh and ICa. It also inhibits endothelium-dependent relaxation of isolated blood vessels.
Preparation
Methylene blue is synthesized commercially by oxidation of N,N-dimethyl-phenylenediamine with sodium dichromate (Na2Cr2O7) in the presence of sodium thiosulfate (Na2S2O3), followed by further oxidation in the presence of N,N-dimethylaniline (NTP, 2008). Methylene blue hydrochloride is isolated by addition of 30% hydrochloric acid and of a saturated common salt solution to the dye solution; after filtration, the product is washed with a 2% common salt solution. Instead of sodium dichromate, manganese dioxide, and catalytic amounts of copper sulfate can be used for the oxidation (Berneth, 2008).
Methylene blue of high purity can be obtained by chloroform extraction of impurities from solutions of raw dye in borate buffer at pH 9.5–10, followed by acidification of the aqueous solution and isolation of the dye (Berneth, 2008).
IARC Monographs
General Description
Methylene blue trihydrate appears as odorless or almost odorless dark green crystals with bronze luster or dark green crystalline powder. pH (1% solution in water) 3 to 4.5. (NTP, 1992)
Air & Water Reactions
Hygroscopic. Water soluble. Gives a blue solution in water.
Reactivity Profile
Methylene Blue trihydrate is incompatible with strong oxidizing agents, caustics, alkali metal iodides and reducing agents. Also incompatible with dichromates. Methylene Blue trihydrate forms double salts with many inorganic salts. Is bleached reversibly by (zinc + hydrochloric acid) or sodium hydrosulfite. In aqueous solution, Methylene Blue trihydrate is decolorized by zinc dust and dilute sulfuric acid, but the color is restored upon exposure to air and more rapidly upon addition of ammonium hydroxide.
Fire Hazard
Flash point data for Methylene Blue trihydrate are not available; however, Methylene Blue trihydrate is probably combustible.
Methylene Blue trihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Arnish Laborates Pvt Ltd | +91 7208475595 | Maharashtra, India | 187 | 58 | Inquiry |
| Garuda Chemicals | +91-8097853976 +91-8097853975 | Maharashtra, India | 58 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Praasa Overseas | 08046050350 | Ahmedabad, India | 68 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Arnish Laborates Pvt Ltd | 58 |
| Garuda Chemicals | 58 |
| JSK Chemicals | 58 |
| CHEMSWORTH | 30 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Triveni chemicals | 58 |
| Central Drug House(P) Ltd. | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Praasa Overseas | 58 |
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