CHLORIN E6
- CAS No.
- 19660-77-6
- Chemical Name:
- CHLORIN E6
- Synonyms
- Chlorine e6;Photolon;CHLORIN E6 TRISODIUM SALT;orin E6;HLORIN E6;Aids006251;CHLORIN E6;Aids-006251;Chlorine a6;PHYTOCHLORIN
- CBNumber:
- CB2365923
- Molecular Formula:
- C34H36N4O6
- Molecular Weight:
- 596.67
- MOL File:
- 19660-77-6.mol
- Modify Date:
- 2023/6/8 9:02:50
| alpha | D20 -141° in acetone |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Isopropanol (Slightly, Heated, Sonicated) |
| form | Solid |
| Boiling point | 1093.7±60.0 °C(Predicted) |
| Density | 1.306±0.06 g/cm3(Predicted) |
| color | Black |
| EPA Substance Registry System | 21H,23H-Porphine-7-propanoic acid, 3-carboxy-5-(carboxymethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-, (7S,8S)- (19660-77-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
CHLORIN E6 Chemical Properties,Uses,Production
Description
Chlorin E6 is a natural molecule and a promising photosensitizer. Chlorin E6 is isolated from renewable natural sources. Chlorin E6 is an attractive photodynamic therapy (PDT) drug candidate because of (1) its high absorption in the red spectral region, and (2) its low cost to make compared to other porphyrin-based PDT drugs. Chlorin E6 exhibits advantageous photophysical properties for PDT such as having long lifetimes in their photoexcited triplet states and high molar absorption in the red region of the visible spectrum. Moreover, a 664-nm laser light can penetrate tissue deeper that the 630-nm laser light used for other PDT drugs. Chlorin E6 is an important starting material for making PDT drug Talaporfin sodium (mono-L-aspartyl chlorin e6 or NPe6).
PDT is currently being used as an alternative therapeutic modality for a variety of malignant tumors. Studies have examined antitumor activity of Ce6-induced PDT (Ce6-PDT) both in vitro and in vivo using a rat tumor models. In one study three-week-old male Sprague-Dawley (SD) rats were inoculated s.c. on the right flank with 5x106 RK3E-ras cells. The animals were administered i.v. with Ce6 (10 mg/kg) and 24 h later, PDT was performed using a laser diode at a light dose of 100 J/cm2. Ce6-PDT generated reactive oxygen species and led to significant growth inhibition in RK3E-ras cell. In addition, Ce6-PDT induced apoptosis through the activation of caspase-3 and its downstream target, PARP cleavage. The protein level of anti-apoptotic bcl-2 was also reduced by Ce6-PDT in RK3E-ras cells. In in vivo experiments, application of Ce6- PDT led to a significant reduction of tumor size. PCNA immunostaining and TUNEL assay revealed that Ce6-PDT inhibited tumor cell proliferation and increased apoptosis. (source: Oncology Reports, 2009, 22(5). 1085-1091.)
Uses
Chlorin E6 is a photosensitizer.The conjugates of gold nanorods and chlorin e6 enhance the fluorescence detection and photodynamic therapy (PDT) of cancers.
CHLORIN E6 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | China | 300 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
| Accela ChemBio Inc. | +1-858-6993322 | United States | 19479 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
| CHEMSOON CO.,LTD. | +8613761723174 | China | 1211 | 58 | Inquiry |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Wuhan Nutra Biotechnology Co.,Ltd | 58 |
| Hangzhou FandaChem Co.,Ltd. | 55 |
| Accela ChemBio Inc. | 58 |
| BOC Sciences | 58 |
| Chongqing Chemdad Co., Ltd | 58 |
| career henan chemical co | 58 |
| CHEMSOON CO.,LTD. | 58 |
| Chengdu Aslee Biopharmaceuticals, Inc. | 58 |
19660-77-6(CHLORIN E6)Related Search:
1of4
chevron_right