Pheophorbide A
- CAS No.
- 15664-29-6
- Chemical Name:
- Pheophorbide A
- Synonyms
- PHEOPHORBIDE A;Phaeophorbide A;Pheophorbide A (>13-Epi-phaeophorbide-a;Chlorophyll Impurity 2;pheophorbide a AldrichCPR;Demagnesia chloric acid -a;Pheophorbide a (mixture of diastereomers);[3s-(3alpha,4beta,21beta)]-ramethyl-20-oxo;Pheophorbide A (>80%) (mixture of diastereomers)
- CBNumber:
- CB4426628
- Molecular Formula:
- C35H36N4O5
- Molecular Weight:
- 592.7
- MOL File:
- 15664-29-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:16
Melting point | 191-195 °C |
---|---|
Boiling point | 1019.0±65.0 °C(Predicted) |
Density | 1.282±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO: soluble0.5mg/mL, clear (warmed) |
form | Solid |
color | blue, to dark brown to black |
Stability | Light Sensitive |
EPA Substance Registry System | 3-Phorbinepropanoic acid, 9-ethenyl-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-, (3S,4S,21R)- (15664-29-6) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
NFPA 704 |
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Pheophorbide A Chemical Properties,Uses,Production
Uses
Pheophorbide a is a chlorophyll-related compound studied for it’s anti-tumor & anti-cancer activity.
Biochem/physiol Actions
Pheophorbide-a, due to its photosensitizing effect, may serve as a promising bioactive compound to treat leishmaniasis. It is a metabolite of chlorophyll and possesses immunostimulation functionality. Pheophorbide-a is a photosensitizer for the photodynamic therapy. It is an ATP Binding Cassette Subfamily G Member 2 (ABCG2) transporter specific substrate. Overexpression of ATP-binding cassette (ABC) transporters in cancer cells is associated with the multidrug resistance phenotype.
Enzyme inhibitor
This chlorophyll a degradation intermediate (MW = 579.68 g/mol; CAS 15664-29-6), which is identical to chlorophyll a, except for the absence of the latter’s magnesium ion and ester at the 17-position, is obtained by acid hydrolysis of chlorophyll a. Pheophorbide a inhibits acyl-CoA:cholesterol acyltransferase and magnesium protoporphyrin IX methyltransferase, acts as an endothelin receptor antagonist, and also induces apoptosis. Pheophorbide a is also as an anti-tumor promoter.
Pheophorbide A Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
Dr. Silviu Pharmachem Pvt., Ltd. | +91-8390608382 +91-8390608382 | Mumbai, India | 248 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29897 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | Inquiry |
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