BUDIPINE
- CAS No.
- 57982-78-2
- Chemical Name:
- BUDIPINE
- Synonyms
- budipin;BUDIPINE;BUDIPINE USP/EP/BP;BUDIPINE(FORR&DONLY);4,4-diphenyl-1-tert-butyl-piperidine;1-TERT-BUTYL-4,4-DIPHENYL-PIPERIDINE;1-(1,1-dimethylethyl)-4,4-diphenylpiperidine;1-(1,1-dimethylethyl)-4,4-diphenyl-piperidin;Piperidine,1-(1,1-dimethylethyl)-4,4-diphenyl-;monoamine oxidase type B (MAO-B),inhibit,CNS disorders,Parkinson disease,Budipine,Inhibitor,dopaminergic
- CBNumber:
- CB2369325
- Molecular Formula:
- C21H27N
- Molecular Weight:
- 293.45
- MOL File:
- 57982-78-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:03
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H332-H335 |
Precautionary statements | P280-P305+P351+P338-P310 |
BUDIPINE Chemical Properties,Uses,Production
Description
Parkinsan was launched in Germany as a centrally-active anti-Parkinsonian agent. It can be prepared in three steps: a Mannich-aldol sequence to assemble the 4-phenylpiperidine scaffold followed by a Friedel-Crafts reaction to introduce the second phenyl ring. Parkinsan is effective for the treatment of Parkinsonian tremors and is similar in action to, but more potent than, biperiden. It exhibits use-dependent, open channel, uncompetitive NMDA receptor antagonistic activity. This may occur by binding to the PCP site in addition to interacting with sigma, binding sites in the frontal cortex. Parkinsan is also an antagonist at presynaptic muscarinic autoreceptors but facilitation of direct or indirect dopaminergic transmission does not contribute to its actions. While its mechanism of action is not completely understood, it has a weak inhibitory effect on dopamine reuptake, inhibits evoked GABA release (with low affinity for GABA-A receptors and a lower affinity for benzodiazepine receptors), and has a weak inhibitory effect on MAO-B.
BUDIPINE Preparation Products And Raw materials
BUDIPINE Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24099 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | China | 40067 | 58 | Inquiry |
Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |