3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

CAS No.: 40254-90-8

Chemical Name:: 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

Synonyms: NSC 693868;Brimonidine Impurity 8;Cdk1/5 Inhibitor inhibitor;3-Aminopyrazolo[3,4-b]quinoxaline;1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE;3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE;1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine;1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI);Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem

CBNumber:: CB2381002

Molecular Formula:: C9H7N5

Molecular Weight:: 185.19

MOL File:: 40254-90-8.mol

Modify Date:: 2024/7/2 8:55:03

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3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Properties

Melting point	292-293℃ (ethanol )
Boiling point	522.8±45.0 °C(Predicted)
Density	1.570±0.06 g/cm3(Predicted)
storage temp.	Store at +4°C
solubility	Soluble to 100 mM in DMSO
form	Red solid
pka	7.40±0.50(Predicted)
color	Orange to red

SAFETY

Risk and Safety Statements

Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	217720	Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem The Cdk1/5 Inhibitor, also referenced under CAS 40254-90-8, controls the biological activity of Cdk1/5. This small molecule/inhibitor is primarily use	40254-90-8	5MG	₹20250	2022-06-14	Buy

Product number	Packaging	Price	Buy
217720	5MG	₹20250	Buy

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Chemical Properties,Uses,Production

Description

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC₅₀s = 600 and 400 nM, respectively). It less potently inhibits GSK3β (IC₅₀ = 1 μM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.

Uses

Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. NSC 693868 is an inhibitor of Cdk1/cyclin B and Cdk5/p25.?Small molecules that target these protein kinases are valuable tools for investigating cellular signaling pathways and are potential therapeutic agents.

Biological Activity

Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Preparation Products And Raw materials

Raw materials

3-Chloroquinoxaline-2-carbonitrile

Preparation Products

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Suppliers

Global( 51)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	China	49739	58	Inquiry
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	China	19947	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Olix (Shanghai) Pharmaceutical Technology Co., Ltd	17316404525	China	9627	58	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6618	81	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24017	58	Inquiry
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	China	8141	58	Inquiry
Shanghai Hao Biological Technology Co., Ltd.	021-58116080 18019263206	CHINA	6921	58	Inquiry

Supplier	Advantage
SynZeal Research Pvt Ltd	58
TargetMol Chemicals Inc.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58
Aladdin Scientific	58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd	58
Cayman Chemical Company	81
TargetMol Chemicals Inc.	58
MedBioPharmaceutical Technology Inc	58
Shanghai Hao Biological Technology Co., Ltd.	58

40254-90-8(3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE)Related Search:

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Brimonidine Related Impurity 3 1H-PYRAZOLO[3,4-B]PYRAZIN-3-AMINE 4,7-DIAZA-1H-INDAZOLE 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

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1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE NSC 693868 1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI) 3-Aminopyrazolo[3,4-b]quinoxaline 1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem Brimonidine Impurity 8 Cdk1/5 Inhibitor inhibitor 40254-90-8 C9H7N5 Protein Kinase PIPERIDINE