9-CIS-RETINOIC ACID
- CAS No.
- 5300-03-8
- Chemical Name:
- 9-CIS-RETINOIC ACID
- Synonyms
- Alitretinoin;Panretin;Tretinoin EP Impurity D;Toctino;LGD 1057;Panretyn;ALRT1057;ALRT 1057;ALRT-1057;NSC 659772
- CBNumber:
- CB2386395
- Molecular Formula:
- C20H28O2
- Molecular Weight:
- 300.44
- MOL File:
- 5300-03-8.mol
- Modify Date:
- 2023/10/16 16:12:12
| Melting point | 189-191°C |
|---|---|
| Boiling point | 462.8±14.0 °C(Predicted) |
| Density | 1.011±0.06 g/cm3(Predicted) |
| RTECS | VH6450000 |
| storage temp. | -20°C |
| solubility | Acetonitrile (Very Slightly), Chloroform (Slightly), DMSO (Slightly), Ethanol ( |
| pka | 4.73±0.33(Predicted) |
| form | Light yellow to orange crystalline powder. |
| color | Pale Yellow to Yellow |
| Water Solubility | Soluble in chloroform (50 mg/ml), DMSO (~25 mg/ml), ethanol (25 mg/ml), and acetone (25 mg/ml). Insoluble in water. |
| Sensitive | Moisture & Light Sensitive |
| Stability | Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months. |
| CAS DataBase Reference | 5300-03-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H319-H335-H360 | |||||||||
| Precautionary statements | P201-P302+P352-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 61-36/37/38 | |||||||||
| Safety Statements | 53-26-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29162090 | |||||||||
| NFPA 704 |
|
9-CIS-RETINOIC ACID Chemical Properties,Uses,Production
Description
Alitretinoin was introduced in the US for the topical treatment of cutaneous lesions in patients with Kaposi's sarcoma (KS), the most frequent malignancy observed in AIDS patients. It is a derivative of 9-cis-retinoic acid (9- cis-RA) identified as an endogenous hormone in mammalian tissues. Alitretinoin binds to all isoforms of the intracellular retinoid X (RXR) and retinoid A (RAR) receptors thus inducing cell differentiation, increasing cell apoptosis and inhibiting cellular proliferation in experimental models of human cancer. In an international phase III trial in patients with KS, 42% of 82 patients treated with 0.1% gel formulation experienced complete or partial responses cf 7% for controls. Alitretinoin is the first topical therapy for KS and is expected to be a new option to its traditional management.
Chemical Properties
Pale Yellow Solid
Uses
9-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. 9-cis-Retinoic acid is an inhibitor of Cox-2 and an activator of RAR α, RAR β, RAR γ and RXR.
Indications
Alitretinoin (Panretin) is a naturally occurring endogenous retinoid that binds to and activates all known retinoid receptors (both RARs and RXRs). It is approved for the topical treatment of cutaneous lesions of Kaposi’s sarcoma. Most patients have local irritation while using alitretinoin gel; however, the irritation rarely necessitates discontinuation of therapy.
Definition
ChEBI: A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.
9-CIS-RETINOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| EAGLE CHEMICAL WORKS | +91-22263303652226330365 +91-2226330365 | Maharashtra, India | 61 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12459 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | China | 4088 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 13102 | 58 | Inquiry |
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