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9-CIS-RETINOIC ACID

9-CIS-RETINOIC ACID Structure
  • ₹9526
  • Product name: 9-CIS-RETINOIC ACID
  • CAS: 5300-03-8
  • MF: C20H28O2
  • MW: 300.44
  • EINECS:1533716-785-6
  • MDL Number:MFCD00270072
  • Synonyms:RETINOIC ACID, 9-CIS-;RARECHEM AL BE 0738;(2E,4E,6Z,8E)-3,7-DIMETHYL-9-(2,6,6-TRIMETHYLCYCLOHEX-1-ENYL)NONA-2,4,6,8-TETRAENOIC ACID;9-CIS-RETINOIC ACID;9-CIS-TRETINOIN;9-cis-tretinoi;3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-t;ALIRETINOIN
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Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberR4643
  • Product description9-cis-Retinoic acid ≥98% (HPLC)
  • Packaging1MG
  • Price₹9526
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) R4643 9-cis-Retinoic acid ≥98% (HPLC) 1MG ₹9526 2022-06-14 Buy

Properties

Melting point :189-191°C
Boiling point :462.8±14.0 °C(Predicted)
Density :1.011±0.06 g/cm3(Predicted)
RTECS :VH6450000
storage temp. :-20°C
solubility :Acetonitrile (Very Slightly), Chloroform (Slightly), DMSO (Slightly), Ethanol (
pka :4.73±0.33(Predicted)
form :Light yellow to orange crystalline powder.
color :Pale Yellow to Yellow
Water Solubility :Soluble in chloroform (50 mg/ml), DMSO (~25 mg/ml), ethanol (25 mg/ml), and acetone (25 mg/ml). Insoluble in water.
Sensitive :Moisture & Light Sensitive
Stability :Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months.
CAS DataBase Reference :5300-03-8(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

9-cis-Retinoic acid is a natural metabolite of vitamin A, derived from the intermediate all-trans retinoic acid . It potently activates all isoforms of retinoic acid receptor (RAR) (Ki = 0.5-27 nM) as well as retinoid X receptor (RXR) isoforms (Ki = 3.8-12 nM). RAR heterodimerizes with RXR, while RXR can homodimerize as well as heterodimerize with numerous partners in addition to RAR, thus allowing 9-cis-retinoic acid to evoke a wide range of effects.

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