YC-1
- CAS No.
- 170632-47-0
- Chemical Name:
- YC-1
- Synonyms
- YC-1;CS-2261;Nsc728165;LIFICIGUAT;Lificiguat(YC-1);YC-1(Lificiguat);YC 1 (pharMaceutical);YC-1 - CAS 170632-47-0 - Calbiochem;1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole;1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole
- CBNumber:
- CB2395371
- Molecular Formula:
- C19H16N2O2
- Molecular Weight:
- 304.34
- MOL File:
- 170632-47-0.mol
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 110-112℃ |
|---|---|
| Boiling point | 522.2±50.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: 12 mg/mL |
| pka | 13.83±0.10(Predicted) |
| form | solid |
| color | white |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
YC-1 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | Y102 | YC-1 powder | 170632-47-0 | 5MG | ₹20080.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | Y102 | YC-1 powder | 170632-47-0 | 25MG | ₹71878 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 688100 | YC-1 - CAS 170632-47-0 - Calbiochem A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. | 170632-47-0 | 5MG | ₹23550 | 2022-06-14 | Buy |
YC-1 Chemical Properties,Uses,Production
Uses
YC-1 has been used as a hypoxia-inducible factor 1α (HIF-1α) inhibitor:
- to reduce hypoxia induced Jagged1 expression in cardiomyocytes (CMs)
- to study its effect on progenitor expansion and CD34+ and side population (SP) cell phenotype and on the proliferation rate of cells with an ability to form long term colony forming units
- to study its effect on regulating sphingosine 1-phosphate (S1P) bound to albumin induced plasminogen activator inhibitor 1 (PAI-1) expression by activating Rho/ Rho-associated protein kinase (ROCK) pathway.
General Description
A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent. Reported to reduce HIF-1α levels and xenograft growth.
Biochem/physiol Actions
YC-1 activates soluble guanylyl cyclase and prevents platelet aggregation and vascular contraction. It has a potential to treat circulation disorders. YC-1 also has an ability to inhibit hypoxia-inducible factor 1α (HIF-1α) activity in vitro. It acts as a potential antiangiogenic anticancer agent.
YC-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 123)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | China | 4128 | 58 | Inquiry |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | China | 3136 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | China | 8474 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
170632-47-0(YC-1)Related Search:
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2-Furanmethanol, 5-[1-(phenylmethyl)-1H-indazol-3-yl]-
Nsc728165
(5-(1-Benzyl-1H-indazol-3-yl)furan-2-yl)Methanol
YC 1 (pharMaceutical)
1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole
1-benzyl-3-(5-hydroxymethyl-furan-2-yl)indazole
Lificiguat(YC-1)
5-[1-(PHENYLMETHYL)-1H-INDAZOL-3-YL]-2-FURANMETHANOL
3-(5'-HYDROXYMETHYL-2'-FURYL)-1-BENZYLINDAZOLE
LIFICIGUAT
YC-1
YC-1 (3-(5'-HYDROXYMETHYL-2'-FURYL)-1-BE NZYL INDAZOLE) \ GUANYLYL CYCLASE ACTI
1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole
YC-1 - CAS 170632-47-0 - Calbiochem
CS-2261
YC-1(Lificiguat)
170632-47-0
C19H16N2O2
Cell Signaling and Neuroscience
Cell Biology
BioChemical
Cyclic Nucleotide Metabolism
G Proteins and Cyclic Nucleotides
Guanylyl Cyclase Activators