4'-METHOXYVALEROPHENONE
- CAS No.
- 1671-76-7
- Chemical Name:
- 4'-METHOXYVALEROPHENONE
- Synonyms
- p-Methoxyvalerophenon;P-METHOXYVALEROPHENONE;4-METHOXYVALEROPHENONE;4'-Methoxyvalerophenone;4'-METHOXYVALEROPHENONE;4-Methoxy-1-phenylpentan-1-one;1-(4-Methoxyphenyl)-1-pentanone;1-(4-Methoxyphenyl)pentane-1-one;1-Pentanone, 1-(4-methoxyphenyl)-;1-(4-METHOXY-PHENYL)-PENTAN-1-ONE
- CBNumber:
- CB2404543
- Molecular Formula:
- C12H16O2
- Molecular Weight:
- 192.25
- MOL File:
- 1671-76-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2022/12/21 16:56:50
| Melting point | 22-23.5 °C |
|---|---|
| Boiling point | 300 °C(Press: 739 Torr) |
| Density | 0.988±0.06 g/cm3(Predicted) |
| CAS DataBase Reference | 1671-76-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
4'-METHOXYVALEROPHENONE Chemical Properties,Uses,Production
Preparation
To a solution of N-methoxy-N-methyl-2-pyridyl urethane (364.4 mg, 2 mmol) in THF (6 mL), p-methoxyphenylmagnesium bromide (0.25 m in THF, 8 mL, 2 mmol) was added dropwise over a period of 10 min at 0 °C under nitrogen atmosphere. Stirring was maintained for a further 5 min and then n-butyllithium (1.60 m in hexane, 1.5 mL, 2.4 mmol) was added directly to the mixture (one-pot process). The reaction mixture was stirred for 0.5 h, while warming to room temperature, and was then quenched with 1 n HCl (5 mL). After evaporation of the THF, the concentrated mixture was poured into 1 n HCl (30 mL) and the aqueous phase was extracted with dichloromethane (3*20 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated to dryness in vacuo. The crude product was purified by column chromatography on silica gel (EtOAc/n-hexane, 1:4) to give 369.1 mg (96%) of p-methoxyvalerophenone.
Synthesis Reference(s)
Chemistry Letters, 15, p. 165, 1986
Tetrahedron, 50, p. 11839, 1994 DOI: 10.1016/S0040-4020(01)89299-1
4'-METHOXYVALEROPHENONE Preparation Products And Raw materials
4'-METHOXYVALEROPHENONE Suppliers
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