Quinine hydrochloride
- CAS No.
- 130-89-2
- Chemical Name:
- Quinine hydrochloride
- Synonyms
- QUININE HC;QUININE HCL;chinimetten;quininemuriate;quininechloride;Quinine Impurity 11;Quinine hydrochlorid;QUININE HYDROCHLORIDE;Quinine HCL & Sulfate;QUININE HCL USP/EP/BP
- CBNumber:
- CB2453521
- Molecular Formula:
- C20H25ClN2O2
- Molecular Weight:
- 360.88
- MOL File:
- 130-89-2.mol
- Modify Date:
- 2024/10/28 23:16:16
| Melting point | 158-160 C |
|---|---|
| Density | 1.1206 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| FEMA | 2976 | QUININE HYDROCHLORIDE |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Ethanol (1g/1ml), glycerol(1g/7ml), chloroform(1g/1ml) |
| form | Solid |
| color | White |
| Water Solubility | 549.7mg/L(25 ºC) |
| InChIKey | LBSFSRMTJJPTCW-QJLYHTAINA-N |
| SMILES | C12C=C(C=CC=1N=CC=C2[C@@H](O)[C@]1([H])C[C@]2([H])CCN1C[C@@H]2C=C)OC.Cl |&1:10,12,15,21,r| |
| LogP | 3.496 (est) |
| EPA Substance Registry System | Cinchonan-9-ol, 6'-methoxy-, hydrochloride (1:1), (8.alpha.,9R)- (130-89-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25 |
| RIDADR | 1544 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29392000 |
| Toxicity | cat,LDLo,intravenous,80mg/kg (80mg/kg),Journal of Pharmacology and Experimental Therapeutics. Vol. 30, Pg. 327, 1927. |
Quinine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Quinine hydrochloride is a white, silky, glittering needles; odourless, effloresces when exposed to warm air. Soluble in water, very soluble in ethanol, freely soluble in chloroform, insoluble in ether. Its solutions are neutral or alkaline to litmus. It is an alkaloid derived from the bark of the cinchona tree. Quinine Hydrochloride is used as ingredient of beverages and injection medication.
Uses
Quinine Hydrochloride is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.
Definition
Quinine Hydrochloride is the hydrochloride of a natural substance, quinine, obtained from the bark of various species of Cinchona including Cinchona succirubra, Pavon. (red cinchona); Cinchona officinalis, Linn; Cinchona calizaya, Wenddell; Cinchona ledgeriana, Moens. It is a nature-derived bitter flavoring agent for tonic water, among other beverages.
Biological Activity
Quinine hydrochloride is a displays antimalarial and muscle relaxant properties. Stereoisomer of quinidine; closely related to chloroquine.?
Safety Profile
Poison by ingestion, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects by intravenous route: convulsions or effect on seizure threshold, muscle contraction or spasticity, and nausea or vomiting. Mutation data reported. Used as a local anesthetic. When heated to decomposition it emits very toxic fumes of NO, and HCI. See also QUININE.
Quinine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Himpharm | +91-9816648055 +91-9816664455 | Himachal Pradesh, India | 29 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Inga Pharmaceuticals | +91-2228202932 +91-2228202932 | Maharashtra, India | 38 | 58 | Inquiry |
| Prism Industries Ltd | +91-9825050731 +91-9227406992 | Gujarat, India | 28 | 58 | Inquiry |
| S M Herbals Pvt Ltd | +91-1124624177 +91-1124624177 | New Delhi, India | 15 | 58 | Inquiry |
| Quad Lifesciences Pvt Ltd | +91-9810034045 +91-9810034045 | New Delhi, India | 23 | 58 | Inquiry |
| Micron Pharmaceuticals | 91-22-24969511 | Maharashtra, India | 43 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6739 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Himpharm | 58 |
| Ralington Pharma | 58 |
| Inga Pharmaceuticals | 58 |
| Prism Industries Ltd | 58 |
| S M Herbals Pvt Ltd | 58 |
| Quad Lifesciences Pvt Ltd | 58 |
| Micron Pharmaceuticals | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Medilink Pharmachem | 50 |
| A.J Chemicals | 58 |
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