Tinidazole
- CAS No.
- 19387-91-8
- Chemical Name:
- Tinidazole
- Synonyms
- tinidazol;1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-1h-imidazol;TIXIAOZUO;1-[2-(ethanesulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazole;pleti;pletil;bioshik;cp12574;fasigin;fasigyn
- CBNumber:
- CB2674744
- Molecular Formula:
- C8H13N3O4S
- Molecular Weight:
- 247.27
- MOL File:
- 19387-91-8.mol
- Modify Date:
- 2024/7/2 8:55:04
| Melting point | 118-120?C |
|---|---|
| Boiling point | 528.4±30.0 °C(Predicted) |
| Density | 1.4338 (rough estimate) |
| refractive index | 1.6320 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Practically insoluble in water, soluble in acetone and in methylene chloride, sparingly soluble in methanol. |
| form | Solid |
| pka | 2.30±0.34(Predicted) |
| color | Off-White to Pale Yellow |
| λmax | 317nm(H2O)(lit.) |
| Merck | 14,9447 |
| BRN | 618182 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | HJLSLZFTEKNLFI-UHFFFAOYSA-N |
| CAS DataBase Reference | 19387-91-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H312+H332-H341-H351 | |||||||||
| Precautionary statements | P201-P202-P280-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-40 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NI6255000 | |||||||||
| HS Code | 2933290000 | |||||||||
| Toxicity | LD50 in mice (mg/kg): >3600 orally; >2000 i.p. (Miller) | |||||||||
| NFPA 704 |
|
Tinidazole price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR2807 | Tinidazole Pharmaceutical Secondary Standard; Certified Reference Material | 19387-91-8 | 400MG | ₹15598.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 32553 | Tinidazole VETRANAL?, analytical standard | 19387-91-8 | 10MG | ₹23695.93 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T3058 | Tinidazole | 19387-91-8 | 5G | ₹2300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T3058 | Tinidazole | 19387-91-8 | 25G | ₹5100 | 2022-05-26 | Buy |
Tinidazole Chemical Properties,Uses,Production
Chemical Properties
solid
Uses
Antiprotozoal (Trichomonas, Giardia); antiamebic; antibacterial.
Antimicrobial activity
Its antibacterial and antiprotozoal activity is similar to that of metronidazole.The MIC against G. vaginalis is 0.2–2 mg/L; the hydroxy metabolite is significantly more active than that of metronidazole. H. pylori is inhibited by 0.5 mg/L. T. vaginalis and T. fetus at 2.5 mg/L and E. histolytica is inhibited by about 0.3–2.5 mg/L.
Pharmaceutical Applications
A 5-nitroimidazole available for oral administration and, in some countries, for intravenous infusion.
Mechanism of action
Tinidazole has a mechanism of action that parallels that of metronidazole as well as a similar metabolic pathway leading to hydroxylation at the 2-methyl group catalyzed by CYP3A4. Basically, tinidazole appears to mimic the actions of metronidazole, although there are reports that it is effective against some protozoa which are resistant to metronidazole.
Clinical Use
Anaerobic bacterial infections(prophylaxis and treatment)
Trichomoniasis
Giardiasis (single dose) Amebiasis (including amebic liver abscess)
Bacterial vaginosis
Gastric colonization with H. pylori (in combination with other agents)
Side effects
Tinidazole is generally well tolerated. Infrequent and transient effects include nausea, vomiting, diarrhea and a metallic taste. Disulfiram-like reactions may occur and rare neurological disturbances and transient leukopenia have been described. Rash, which may be severe, urticaria and angioneurotic edema can occur.
Tinidazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AnalyticsStanza Inc | +91-7032031309 +91-7032031309 | Hyderabad, India | 227 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Dishman Carbogen Amcis Ltd (Dishman Group) | +91-2717420100 +91-8154017093 | Gujarat, India | 90 | 58 | Inquiry |
| Anuja Healthcare Ltd | +91-6239597015 +91-9815004047 | Punjab, India | 26 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Globela Industry Pvt Ltd | +91-2616158000 +91-9998199919 | Gujarat, India | 98 | 58 | Inquiry |
| Unidrug Innovative Pharma Technologies Ltd | +91-7312533576 +91-7312533324 | Madhya Pradesh, India | 9 | 58 | Inquiry |
| Aarti Drugs Ltd (part of Aarti Group of Industries) | +91-2224019025 +91-9136988221 | Maharashtra, India | 57 | 58 | Inquiry |
| Elppe Chemicals Private Limited | +91-2240109150 +91-2240159160 | Maharashtra, India | 34 | 58 | Inquiry |
| Biofil Chemicals and Pharmaceuticals Limited | +91-7312426700 +91-7312426713 | Madhya Pradesh, India | 12 | 58 | Inquiry |
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