3-Amino-1-propanesulfonic acid
- CAS No.
- 3687-18-1
- Chemical Name:
- 3-Amino-1-propanesulfonic acid
- Synonyms
- HOMOTAURINE;3-AMINOPROPANE-1-SULFONIC ACID;3 APS;NC 758;TRAMIP;Alzhemed;NSC 77071;Homotaurin;TRAMIPROSATE;3-Sulfopropylamine
- CBNumber:
- CB2741107
- Molecular Formula:
- C3H9NO3S
- Molecular Weight:
- 139.17
- MOL File:
- 3687-18-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/17 18:50:11
| Melting point | 293 °C (dec.)(lit.) |
|---|---|
| Density | 1.202 (estimate) |
| refractive index | 1.5130 (estimate) |
| storage temp. | 2-8°C |
| solubility | Water (Slightly) |
| form | Crystalline Powder |
| pka | 1.06±0.50(Predicted) |
| color | White to slightly blue |
| LogP | -4.555 |
| CAS DataBase Reference | 3687-18-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 1 | |||||||||
| HS Code | 29049090 | |||||||||
| NFPA 704 |
|
3-Amino-1-propanesulfonic acid price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A76109 | 3-Amino-1-propanesulfonic acid 97% | 3687-18-1 | 1G | ₹4232.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2822 | Acamprosate Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 3687-18-1 | 50MG | ₹44804.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A76109 | 3-Amino-1-propanesulfonic acid 97% | 3687-18-1 | 5G | ₹13314.75 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A2602 | 3-Amino-1-propanesulfonic Acid | 3687-18-1 | 5G | ₹8300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A2602 | 3-Amino-1-propanesulfonic Acid | 3687-18-1 | 25G | ₹10800 | 2022-05-26 | Buy |
3-Amino-1-propanesulfonic acid Chemical Properties,Uses,Production
Description
Homotaurine (also known as tramiprosate (INN), 3-amino-1-propanesulfonic acid, or 3-APS) is a natural sulfonic acid found in seaweed. Tramiprosate is a sulfated glycosaminoglycan mimetic that was reported to bind soluble Aβ and inhibit the interaction of Aβ with endogenous glycosaminoglycans, thereby preventing β-sheet formation. Conversely, tramiprosate was also reported to promote tau polymerization into fibrillar aggregates. It is also an analog of GABA that can act as a partial agonist of GABAA receptors, as well as an antagonist at GABAB receptors.
Chemical Properties
White Powder
Uses
3-Amino-1-propanesulfonic acid is a Important gabamimetic agent-evokes neurological responses similar to those elicited by γ-aminobutyric acid (GABA). It is an intermediate in the synthesis of acamprosate. acamprosate is an alcohol addiction treatment commonly used to reduce urges to drink and help people in recovery remain sober.
Biological Activity
Sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (A β ) and maintains A β in a non-fibrillar form. Decreases A β 42-induced neuronal death and inhibits amyloid deposition in vitro . Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo .
3-Amino-1-propanesulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Ind-Swift Laboratories Ltd. | 91-11-26226140 | Delhi, India | 28 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Opulent Pharma | 08068441147Ext 981 | Gujarat, India | 810 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Alfa Aesar | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Ind-Swift Laboratories Ltd. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Pharma Affiliates | 58 |
| Opulent Pharma | 58 |
| Reax Chemicals | 58 |