GLIOTOXIN
- CAS No.
- 67-99-2
- Chemical Name:
- GLIOTOXIN
- Synonyms
- S-82;GLIOTOXIN;s.n.12870;Nsc102866;Aids086418;aspergillin;Aids-086418;Gliotoxin solution;Aspergillin solution;Aspergillin, SN 12879, SN 12870
- CBNumber:
- CB2745332
- Molecular Formula:
- C13H14N2O4S2
- Molecular Weight:
- 326.39
- MOL File:
- 67-99-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 221°C (rough estimate) |
|---|---|
| Boiling point | 699.7±55.0 °C(Predicted) |
| alpha | D25 -290° (c = 0.08 in ethanol) |
| Density | 1.4069 (rough estimate) |
| refractive index | 1.6510 (estimate) |
| Flash point | 2℃ |
| storage temp. | 2-8°C |
| solubility | chloroform: 10 mg/mL, clear, colorless |
| form | White solid |
| pka | 12.90±0.40(Predicted) |
| color | Monoclinic crystals from MeOH |
| Merck | 13,4454 |
| BRN | 50675 |
| Stability | Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| Hazard Codes | T,Xn,F | |||||||||
| Risk Statements | 25-36-20/21/22-11 | |||||||||
| Safety Statements | 36/37/39-45-36/37-16 | |||||||||
| RIDADR | UN 3462 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KB4725000 | |||||||||
| F | 4.2-10-23 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29419090 | |||||||||
| Toxicity | LD50 oral in mouse: 67mg/kg | |||||||||
| NFPA 704 |
|
GLIOTOXIN price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G9893 | Gliotoxin from Gliocladium fimbriatum | 67-99-2 | 5MG | ₹25666.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G9893 | Gliotoxin from Gliocladium fimbriatum | 67-99-2 | 25MG | ₹97977.08 | 2022-06-14 | Buy |
| Sigma-Aldrich | 371715 | Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem An immunosuppressive secondary metabolite produced by several pathogenic fungi. | 67-99-2 | 1MG | ₹13100 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 371715 | Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem An immunosuppressive secondary metabolite produced by several pathogenic fungi. | 67-99-2 | 1MG | ₹13100 | 2022-06-14 | Buy |
GLIOTOXIN Chemical Properties,Uses,Production
Chemical Properties
White powder
Uses
Gliotoxin is a sulfur-containing mycotoxin produced by species of fungi and pathogens of humans. Gliotoxin exhibits inhibitory activities against histone H3K9 methyltransferase, a key enzyme in the re gulation of transcriptional activity by writing epigenetic marks. Gliotoxin also exhibits immunosuppressive properties by causing apoptosis of cells of the immune system. In addition, various studies suggests Gliotoxin may also be a potential anti-inflammatory, antibiotic, antifungal and antiviral agent.
Definition
ChEBI: A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.
Hazard
Poison.
Biological Activity
Immunosuppressive agent; blocks phagocytosis, cytokine production and proliferation of T and B cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome; prevents degradation of I κ B α , an endogenous blocker of NF- κ B. Also inhibits farnesyltransferase and geranylgeranyltransferase I (IC 50 values are 80 and 17 μ M respectively) and displays antitumor activity against breast cancer in vivo .
Safety Profile
Poison by intraperitoneal andintravenous routes. When heated to decomposition itemits very toxic fumes such as SOx and NOx.
Purification Methods
Purify gliotoxin by recrystallisation from MeOH. Its solubility in CHCl3 is 1%. The dibenzoyl derivative has m 202o (from CHCl3/MeOH). [Glister & Williams Nature 153 651 1944, Elvidge & Spring J Chem Soc Suppl 135 1949, Johnson et al. J Am Chem Soc 65 2005 1943, Bracken & Raistrick Biochem J 41 569 1947.]
GLIOTOXIN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3424 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | China | 19947 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |