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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Food and cosmetics standards >GLIOTOXIN

GLIOTOXIN

GLIOTOXIN Structure
  • ₹13100 - ₹97977.08
  • Product name: GLIOTOXIN
  • CAS: 67-99-2
  • MF: C13H14N2O4S2
  • MW: 326.39
  • EINECS:636-170-3
  • MDL Number:MFCD00058534
  • Synonyms:GLIOTOXIN;GLIOTOXIN, GLADIOCLADIUM FIMBRIATUM;2,3,5A,6-TETRAHYDRO-6-HYDROXY-3(HYROXYMETHYL)-2-METHYL-10H-3A, 10A-EPIDITHIO-PYRAZINOL[1,2ALPHA]INDOLE-1,4-DIONE;(3r-(3-alpha,5a-beta,6-beta,10a-alpha))-ymethyl)-2-methyl ;10h-3,10a-epidithiopyrazino(1,2-a)indole-1,4-dione,2,3,5a,6-hydroxy-3-(hydrox ;aspergillin ;s.n.12870 ;gliotoxin from gliocladium fimbriatum
Price4 Properties Safety Information Description
4 prices
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Brand

  • Sigma-Aldrich
  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich
  • Product number371715
  • Product descriptionGliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem An immunosuppressive secondary metabolite produced by several pathogenic fungi.
  • Packaging1MG
  • Price₹13100
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number371715
  • Product descriptionGliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem An immunosuppressive secondary metabolite produced by several pathogenic fungi.
  • Packaging1MG
  • Price₹13100
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberG9893
  • Product descriptionGliotoxin from Gliocladium fimbriatum
  • Packaging5MG
  • Price₹25666.08
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberG9893
  • Product descriptionGliotoxin from Gliocladium fimbriatum
  • Packaging25MG
  • Price₹97977.08
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich 371715 Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem An immunosuppressive secondary metabolite produced by several pathogenic fungi. 1MG ₹13100 2022-06-14 Buy
Sigma-Aldrich(India) 371715 Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem An immunosuppressive secondary metabolite produced by several pathogenic fungi. 1MG ₹13100 2022-06-14 Buy
Sigma-Aldrich(India) G9893 Gliotoxin from Gliocladium fimbriatum 5MG ₹25666.08 2022-06-14 Buy
Sigma-Aldrich(India) G9893 Gliotoxin from Gliocladium fimbriatum 25MG ₹97977.08 2022-06-14 Buy

Properties

Melting point :221°C (rough estimate)
Boiling point :699.7±55.0 °C(Predicted)
alpha :D25 -290° (c = 0.08 in ethanol)
Density :1.4069 (rough estimate)
refractive index :1.6510 (estimate)
Flash point :2℃
storage temp. :2-8°C
solubility :chloroform: 10 mg/mL, clear, colorless
form :White solid
pka :12.90±0.40(Predicted)
color :Monoclinic crystals from MeOH
Merck :13,4454
BRN :50675
Stability :Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi. It inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB. Gliotoxin also induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils. It also inhibits geranylgeranyltransferase I and farnesyltransferase (IC50 = 17 and 80 μM, respectively). Gliotoxin potently suppresses viral infection by Nipah and Hendra virus in vitro (IC50 = 149 and 579 nM, respectively). While gliotoxin production by fungi correlates with invasiveness, its role in aspergillosis remains unclear.

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