mopidamol

mopidamol  Structure
CAS No.
13665-88-8
Chemical Name:
mopidamol
Synonyms
RA-233;Rapenton;mopidamol;Compound RA-233;2,2',2'',2'''-[[4-Piperidinopyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetraethanol;2,2',2'',2'''-[(4-Piperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol;2,2',2'',2'''-[[4-(1-Piperidinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol;Ethanol, 2,2',2'',2'''-[[4-(1-piperidinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakis- (9CI)
CBNumber:
CB2937119
Molecular Formula:
C19H31N7O4
Molecular Weight:
421.499
MOL File:
13665-88-8.mol
Modify Date:
2025/6/18 8:43:23

mopidamol Properties

Melting point 157-158°
Boiling point 738.6±70.0 °C(Predicted)
Density 1.401±0.06 g/cm3(Predicted)
pka 13.85±0.10(Predicted)

mopidamol Chemical Properties,Uses,Production

Originator

Rapenton,Thomae,W. Germany,1980

Manufacturing Process

3.9 g (0.06 mol) of zinc powder were introduced into a solution of 5.0 g (0.01 mol) of 2,6-bis-(diethanolamino)-4,8-dipiperidino-pyrimido-[5,4-d]-pyrimidine (dipyridamole; see entry under that name for its synthesis) in 120 cc of aqueous 10% formic acid. The resulting mixture was heated on a water bath, while occasionally stirring, until the intense yellow color of the starting compound disappeared, which occurred after about 30 to 40 minutes. Thereafter, the unconsumed zinc powder was separated by vacuum filtration, the virtually colorless filtrate was essentially an aqueous solution of 2,6-bis- (diethanolamino)-8-piperidino-1,2,3,4-tetrahydropyrimido-[5,4-d]pyrimidine.
The filtrate was adjusted to a pH of 9 by adding concentrated ammonia, and then a 1 N aqueous iodine-potassium iodide solution was added dropwise, whereby the tetrahydropyrimido[5,4-d]pyrimidine obtained by hydrogenation with zinc in formic acid was converted by oxidation into 2,6-bis- (diethanolamino)-8-piperidino-pyrimido-[5,4-d]-pyrimidine. The completion of the oxidation was checked by means of a starch solution. The major amount of the oxidation product already separated out as a deep yellow crystalline precipitate during the addition of the iodine solution. After the oxidation reaction was complete, the reaction mixture was allowed to stand for a short period of time, and then the precipitate was separated by vacuum filtration,washed with water and dried. It had a melting point of 157°C to 158°C. The yield was 8.0 g, which corresponds to 95% theory.

Therapeutic Function

Platelet aggregation inhibitor

mopidamol Preparation Products And Raw materials

Raw materials

Preparation Products

mopidamol Suppliers

Global( 8)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +17819995354 United States 32298 58 Inquiry
Proteintech China 027-87531629 CHINA 6290 58 Inquiry
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 China 6710 58 Inquiry
Absin Bioscience Inc. 021-38015121-8802 CHINA 6208 58 Inquiry
Lanospharma Laboratories Co.,Ltd 13440048448 China 6329 56 Inquiry
Shaanxi Dideu Newmaterial Co., Ltd. 029-63373950 17392213970 China 9936 58 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 11973 58 Inquiry
TargetMol Chemicals Inc. 15002134094 China 23192 58 Inquiry
mopidamol 2,2',2'',2'''-[(4-Piperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol 2,2',2'',2'''-[[4-(1-Piperidinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol 2,2',2'',2'''-[[4-Piperidinopyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetraethanol Compound RA-233 RA-233 Ethanol, 2,2',2'',2'''-[[4-(1-piperidinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakis- (9CI) Rapenton 13665-88-8 C19H31N7O4