Dipyridamole | 58-32-2

Dipyridamole Properties

Melting point	165-166 °C (lit.)
Boiling point	593.96°C (rough estimate)
Density	1.2046 (rough estimate)
refractive index	1.6910 (estimate)
storage temp.	room temp
solubility	DMSO: soluble
form	powder
pka	pKa 6.4 (Uncertain)
color	yellow
Water Solubility	Soluble in chloroform, methanol, dilute acids, ethanol. Slightly soluble in water.
Merck	14,3346
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
NIST Chemistry Reference	Pyrimidine, 2,6-bis(diethanolamino)-4,8-dipiperidino-pyrimido-(5,4-d)-(58-32-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

2

RTECS

KK7450000

HS Code

29335990

Toxicity

LD50 in rats: 8.4 g/kg orally; 208 mg/kg i.v. (Takenaka)

NFPA 704

	0
2		0

Dipyridamole price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	D9766	Dipyridamole ≥98% (HPLC)	58-32-2	1G	₹4254.23	2022-06-14	Buy
Sigma-Aldrich(India)	D9766	Dipyridamole ≥98% (HPLC)	58-32-2	5G	₹12654.43	2022-06-14	Buy
Sigma-Aldrich(India)	D9766	Dipyridamole ≥98% (HPLC)	58-32-2	10G	₹20491.73	2022-06-14	Buy
Sigma-Aldrich(India)	D9766	Dipyridamole ≥98% (HPLC)	58-32-2	25G	₹40301.48	2022-06-14	Buy
TCI Chemicals (India)	D2274	Dipyridamole	58-32-2	5G	₹4800	2022-05-26	Buy

Product number	Packaging	Price	Buy
D9766	1G	₹4254.23	Buy
D9766	5G	₹12654.43	Buy
D9766	10G	₹20491.73	Buy
D9766	25G	₹40301.48	Buy
D2274	5G	₹4800	Buy

Dipyridamole Chemical Properties,Uses,Production

Chemical Properties

Yellow Powder

Uses

Dipyridamole prevents platelets sticking to the replacement heart valve and causing a blood clot on the valve. It is used to dilate blood vessels in people with peripheral arterial disease and coronary artery disease. This compound has been shown to suppress high glucose-induced osteopontin mRNA expression and protein secretion, as well as inhibit cAMP and cGMP hydrolysis. Research indicates that Dipyridamole is a non-specific nucleoside transport inhibitor with the ability to increase the effects of adenosine in sinoatrial and atrioventricular nodes. Dipyridamole is an inhibitor of ENT1 and ENT2.

Definition

ChEBI: A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.

General Description

Dipyridamole, 2,2',2',2'''-[(4,8-di-1piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]-tetrakisethanol (Persantine), may be used for coronary andmyocardial insufficiency. Its biggest use today, however, isas an antithrombotic in patients with prosthetic heart valves.It is a bitter, yellow, crystalline powder, soluble in diluteacids, methanol, or chloroform. A formulation containingdipyridamole and aspirin (Aggrenox) is currently beingmarketed as an antithromobotic.
Dipyridamole is a long-acting vasodilator. Its vasodilatingaction is selective for the coronary system; it is indicatedfor long-term therapy of chronic angina pectoris. Thedrug also inhibits adenosine deaminase in erythrocytesand interferes with the uptake of the vasodilator adenosineby erythrocytes. These actions potentiate the effect ofprostacyclin (PGI₂), which acts as an inhibitor to plateletaggregation.

Biological Activity

Coronary vasodilator; adenosine transport inhibitor. Phosphodiesterase inhibitor (IC 50 values are 0.37, 0.38, 0.45, 0.9 and 4.5 μ M? for PDE11, 6, 10, 5 and 8 respectively).

Mechanism of action

Dipyridamole exerts its antiplatelet function by increasing cellular concentrations of cAMP via its inhibition of the degradating enzyme, cyclic nucleotide PDE3. It also blocks adenosine uptake, which acts at A2 adenosine receptors to stimulate platelet adenyl cyclase. Less common uses for this drug include inhibition of embolization from prosthetic heart valves when used in combination with warfarin (the only currently recommended use) and reduction of thrombosis in patients with thrombotic disease when used in combination with aspirin. Alone, dipyridamole has little, if any, benefit in the treatment of thrombotic conditions.

Clinical Use

Dipyridamole is a pyrimidopyrimidine derivative with vasodilatory and antiplatelet properties.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Human systemic effects cardiomyopathy including infarction. Mutation data reported. Used as a coronary vasodilator. When heated to decomposition it e

Dipyridamole Preparation Products And Raw materials

Raw materials

5-AMINOOROTIC ACID Nitric acid Hydrogen Potassium cyanate Diethanolamine

Phosphorus oxychloride Piperidine Ethyl acetoacetate Phosphorus oxychloride

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Preparation Products

Dipyridamole Suppliers

Global( 476)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Glenmark Pharmaceuticals Limited	+912240189999	Maharashtra, India	93	58	Inquiry
Lakshmi Farmachem	+91-9948795885 +91-9550886476	Telangana, India	407	58	Inquiry
Solara Active Pharma Sciences Ltd	+91-8046632100 +91-7075706520	Bangalore, India	65	58	Inquiry
Cohance Lifesciences (Previously RA Chem Pharma Ltd)	+91-4044758595 +91-4044758595	Telangana, India	47	58	Inquiry
Vijaya Pharma And Life Science	+91-8939866271 +91-8939866271	Tamil Nadu, India	320	58	Inquiry
Mylan Laboratories Ltd	+91-4023550543 +91-4030866666	Telangana, India	150	58	Inquiry
SETV ASRV LLP	+91-9731133411 +91-9731133411	Telangana, India	531	58	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
SOLARA ACTIVE PHARMA SCIENCES LTD	+91 44 4344 6700	New Delhi, India	89	58	Inquiry
GLENMARK LIFE SCIENCES LTD	+91 22 4018 9999	New Delhi, India	103	58	Inquiry

Supplier	Advantage
Glenmark Pharmaceuticals Limited	58
Lakshmi Farmachem	58
Solara Active Pharma Sciences Ltd	58
Cohance Lifesciences (Previously RA Chem Pharma Ltd)	58
Vijaya Pharma And Life Science	58
Mylan Laboratories Ltd	58
SETV ASRV LLP	58
Manus Aktteva	34
SOLARA ACTIVE PHARMA SCIENCES LTD	58
GLENMARK LIFE SCIENCES LTD	58

Dipyridamole Spectrum

Dipyridamole(58-32-2)MS Dipyridamole(58-32-2)¹HNMR Dipyridamole(58-32-2)¹³CNMR Dipyridamole(58-32-2)IR1 Dipyridamole(58-32-2)IR2 Dipyridamole(58-32-2)Raman

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2,2',2'',2'''-((4,8-Di(piperidin-1-yl)pyrimido[5,4-d]-pyrimidine-2,6-diyl)bis(azanetriyl))tetraet Corosan Coroxin Curantyl Dipyridamine Dipyridan Dipyudamine Ethanol, 2,2',2'',2'''-(4,8-dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyldinitrilo)tetra- Ethanol, 2,2',2'',2'''-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis- ethanol,2,2’,2’’,2’’’-((4,8-dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)din etraethanol Gulliostin itrilo)tetra- Justpertin Kurantil Natyl NSC-515776 Peridamol Permiltin Piroan Prandiol Prandiol 75 Protangix Pyrimido(5,4-d)pyrimidine, 2,6-bis(bis(2-hydroxyethyl)amino)-4,8-diperidino- Pyrimido(5,4-d)pyrimidine, 2,6-bis(bis(2-hydroxyethyl)amino)-4,8-dipiperidino- 2,2',2'',2'''-((4,8-Di(piperidin-1-yl)pyriMido[5,4-d]pyriMidine-2,6-diyl)bis(azanetriyl))tetraethanol DypyridaMole API 2,6-Bis(diethanolamine)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine 2,2',2'',2'''-[(4,8-Dipiperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol 2,6-BIS(DIETHANOLAMINE)-4,8-DIPIPERIDINOPYRIMIDO[5,4-D]PYRIMIDINE 2,6-bis(diethanolamino)-4,8-dipiperidinopyrimido-[5,4-d]pyrimidin 2,6-BIS(DIETHANOLAMINO)-4,8-DIPIPERIDINOPYRIMIDO[5,4-D]PYRIMIDINE 2,2',2'',2'''-4,8-DIPIPERIDINO-PYRIMIDO [5,4-D] PYRIMIDINE-2,6-DIYLDINITRILOTETRAETHANOL 2,2',2'',2'''-[(4,8-DIPIPERIDINYLPYRIMIDO[5,4-D]PYRIMIDINE-2,6-DIYL)DINITRILO]TETRAKISETHANOL Dipyridamole (FDA) Dipyridamole,98% Dypyridamol DIPYRIDAMOLE CORONARY VASODILATOR DIPYRIDAMOLE,USP Dipyrdamole 2,2',2'',2'''-((4,8-Di(piperidin-1-yl)pyrimido[5,4-d]-pyrimidine-2,6-diyl)bis(azanetriyl))tetr 2,2',2'',2'''-[(4,8-Dipiperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol 2,2’,2’’,2’’’-(4,8-dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyldinitrilo)t 2,2’,2’’,2’’’-[(4,8-Di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol Agilease Apricor Cardioflux Cardoxil Chilcolan Cleridium Cleridium 150 cleridium150 Coribon Coridil Coronarine pyrimido(5,4-d)pyrimidine,2,6-bis(bis(2-hydroxyethyl)amino)-4,8-dipiperidino RA 8 ra8 Stenocardil