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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Structure
CAS No.
6713-54-8
Chemical Name:
2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
Synonyms
Nsc20089;Homouric;tetratomic;homouric acid;Dipyridamole Impurity 8;2,6,8,10-Tetrahydroxy-homopurine;Pyrimido[5,4-d]Pyrimidine Impurity 1;Pyrimido[5,4-d]pyrimidine-2,4,6,8-tetrol;pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraol;pyriMido[5,4-d][1,3]diazine-2,4,6,8-tetrol
CBNumber:
CB6875585
Molecular Formula:
C6H4N4O4
Molecular Weight:
196.12
MOL File:
6713-54-8.mol
Modify Date:
2022/12/21 16:56:50
Request For Quotation

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Properties

Density 1.89±0.1 g/cm3(Predicted)
pka 5.90±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Chemical Properties,Uses,Production

Uses

2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is a pharmaceutical intermediate used in the preparation of Dipyridamole, an antiplatelet drug that is used primarily in the treatment of ischaemic heart disease and stroke. 2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is also used as a herbicide to control broadleaf weeds in wheat crops.

Synthesis

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4d)Pyrimidine is prepared by the reaction of 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid and urea. The specific synthesis steps are as follows:
5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid was charged into a two nicked flask, Urea (7.7 g, 128.0 mmol) was added dropwise with 125 ml of NaOH solution (500 g of sodium hydroxide + 1500 g of purified water) After dripping rapidly warming to 100 ° C,Insulation for one hour; continue to stir 3h,(25 ° C), filtered to obtain a solid, add purified water 250ml, heated to 60 ° C, heat lh, and then add dilute hydrochloric acid to ΡΗ = 4, cooled to room temperature filtration, washed and dried to obtain pyrimidine [5 , 4-d] pyrimidine-2,4,6,8-tetraol (tetrahydroxy), and recrystallized (ethanol solvent) to give 10.9 g in 86.9% yield.
2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine synthesis

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Preparation Products And Raw materials

Raw materials

5-AMINOOROTIC ACID Urea

Preparation Products

2,4,6,8-TETRACHLOROPYRIMIDO[5,4-D]PYRIMIDINE 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Suppliers

Global( 125)Suppliers
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VGS SYNTHESIS PRIVATE LIMITED +91-9866975588 +91-9866975588 Hyderabad, India 1818 58 Inquiry
Manus Aktteva +91 (79) 6512-3395 New Delhi, India 581 34 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21662 55 Inquiry
Zhejiang ZETian Fine Chemicals Co. LTD +8618957127338 China 2136 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49403 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29820 58 Inquiry
Supplier Advantage
VGS SYNTHESIS PRIVATE LIMITED 58
Manus Aktteva 34
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
CHEMSWORTH 30
Capot Chemical Co.,Ltd. 60
Henan Tianfu Chemical Co.,Ltd. 55
Zhejiang ZETian Fine Chemicals Co. LTD 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58

6713-54-8(2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine)Related Search:

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Dipyridamole Mono-O-b-D-glucuronide Dipyridamole 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine 2,4,6,8-TETRACHLOROPYRIMIDO[5,4-D]PYRIMIDINE
2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(2,2,3,3,4,4,5,5,6,6-decadeuteriopiperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol 2,2',2'',2'''-[[4-[(2-Hydroxyethyl)aMino]-8-(1-piperidinyl)pyriMido[5,4-d]pyriMidine-2,6-diyl]dinitrilo]tetrakisethanol (DipyridaMole IMpurity) Dipyridamole Tripiperidine Dipyridamole Tri(diethanolamine) 6-Des(diethanolamino)-6-chloro Dipyridamole
4,8-dichloro-2,6-dipiperidinopyrimido[5,4-d]pyrimidine Desethanol Dipyridamole Pyrimido[5,4-d]pyrimidin-4-ol (8CI) 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine
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1,5-dihydropyrimido[5,4-d]pyrimidine-2,4,6,8(3H,7H)tetrone 2,6,8,10-Tetrahydroxy-homopurine 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Homouric homouric acid 1,2,3,4,5,6,7,8-Octahydropyrimido[5,4-d]pyrimidine-2,4,6,8-tetrone Pyrimido[5,4-d]pyrimidine-2,4,6,8(1H,3H,5H,7H)-tetrone Pyrimido[5,4-d]pyrimidine-2,4,6,8-tetrol Nsc20089 pyriMido[5,4-d][1,3]diazine-2,4,6,8-tetrol pyriMido[5,4-d]pyriMidine-2,4,6,8(1H,3H,5H,7H)-tetraone pyrimido[5,4-d]pyrimidine-2,4,6,8-tetraol 1H,2H,3H,4H,5H,6H,7H,8H-[1,3]DIAZINO[5,4-D]PYRIMIDINE-2,4,6,8-TETRONE 1,5-dihydropyrimido[5,4-d]pyrimidine-2,4,6,8-tetrone ,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Dipyridamole Impurity 8 Pyrimido[5,4-d]Pyrimidine Impurity 1 2,4,6,8-TETRAHYDROXYPYRIMIDO-[5,4-D]PYRIMIDIN Pyrimido[5,4-d]pyrimidine-2,4,6,8(3H,7H)-tetrone, 1,5-dihydro- 2,4,6,8-Tetrahydroxy-pynmido[5,4-d]pynmidine tetratomic 6713-54-8 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine 2,4,6, 8-tetrahydroxy pyrimidine and [5, 4-D] pyrimidine 6713-54-8 Heterocycle-Pyrimidine series