Endoxifen

Endoxifen Structure
CAS No.
112093-28-4
Chemical Name:
Endoxifen
Synonyms
Avacopan;Endoxifen;Endoxifen(Z);(Z)-Endoxifen;Endoxifen (Z-isomer);salt CAS1032008-74-4;Tamoxifen Impurity 15;Endoxifen HCl Endoxifen Z-isomer;(Z)-4-Hydroxy-N-desmethyl Tamoxifen;Endoxifen Z-isomer (contains 3% E isomer))
CBNumber:
CB31872472
Molecular Formula:
C25H27NO2
Molecular Weight:
373.49
MOL File:
112093-28-4.mol
MSDS File:
SDS
Modify Date:
2024/7/11 17:04:31

Endoxifen Properties

Melting point 127-129°C
Boiling point 519.3±50.0 °C(Predicted)
Density 1.099±0.06 g/cm3(Predicted)
storage temp. Amber Vial, -86°C Freezer, Under Inert Atmosphere
solubility DMSO : 50 mg/mL (133.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form Powder
pka 10.36±0.15(Predicted)
color White to off-white
Stability Light Sensitive, Temperature Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H302-H361-H372-H410
Precautionary statements  P201-P264-P280-P301+P330+P331-P312

Endoxifen Chemical Properties,Uses,Production

Chemical Properties

Off-White to Pink Solid

Uses

A novel active metabolite of the anti-cancer drug Tamoxifen. It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast ca

Endoxifen Preparation Products And Raw materials

Raw materials

Preparation Products

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Endoxifen Spectrum

(Z)-4-Hydroxy-N-desmethyl Tamoxifen 4-[(1Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol Endoxifen Phenol, 4-[(1Z)-1-[4-[2-(MethylaMino)ethoxy]phenyl]-2-phenyl-1-butenyl]- (Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer) see D292043 (Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer) (Z)-4-Hydroxy-N-DesMethyl TaMoxifen (Endoxifen) (Z)-Endoxifen Endoxifen (Z-isomer) Avacopan 4-[(1Z)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol (Z)-4-Hydroxy-N-desmethyl Tamoxifen (mixture of isomers) (Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains 3% E isomer) Endoxifen(Z) salt CAS1032008-74-4 4-[(Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol (E/Z)-4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol (Z)-4-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol Endoxifen Z-isomer (contains 3% E isomer)) Phenol, 4-[(1Z)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]- Tamoxifen Citrate Impurity 17((Z)-4-Hydroxy-N-Desmethyl Tamoxifen) Endoxifen HCl Endoxifen Z-isomer Tamoxifen Impurity 15 Potassium Channel,Endoxifen (Z-isomer),Endoxifen (Zisomer),Endoxifen (Z isomer),Inhibitor,KcsA,inhibit,Estrogen Receptor/ERR 112093-28-4 Inhibitors Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals Aromatics Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals