TAMOXIFEN-N-OXIDE

TAMOXIFEN-N-OXIDE Structure
CAS No.
75504-34-6
Chemical Name:
TAMOXIFEN-N-OXIDE
Synonyms
Tamoxifen epoxide;TAMOXIFEN-N-OXIDE;Tamoxifen Citrate Impurity 12 (Tamoxifen N-oxide);(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine-N-oxide;2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine N-oxide;Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, N-oxide, (Z)-;Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-, N-oxide
CBNumber:
CB2506809
Molecular Formula:
C26H29NO2
Molecular Weight:
387.51
MOL File:
75504-34-6.mol
Modify Date:
2024/7/2 8:55:04

TAMOXIFEN-N-OXIDE Properties

storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility DMF: 20 mg/mL; DMSO: 2 mg/mL; Ethanol: 20 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL
form A crystalline solid
pka 4.49±0.40(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H350-H360
Precautionary statements  P201-P202-P280-P308+P313-P405-P501

TAMOXIFEN-N-OXIDE Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A metabolite of Tamoxifen, a nonsteroidal estrogen antagonist of interest in the treatment of some forms of breast cancer. Tamoxifen is a Protein Kinase C inhibitor, and induces apoptosis in human malignant glioma cell lines

Definition

ChEBI: An N-oxide derived from tamoxifen.

TAMOXIFEN-N-OXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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TAMOXIFEN-N-OXIDE (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine-N-oxide Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, N-oxide, (Z)- Tamoxifen epoxide 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine N-oxide Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-, N-oxide Tamoxifen Citrate Impurity 12 (Tamoxifen N-oxide) 75504-34-6 Aromatics Nitric Oxide Reagents Various Metabolites and Impurities Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Protein Kinase Inhibitors and Activators