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4Hydroxy Tamoxifen

4Hydroxy Tamoxifen Structure
CAS No.
82413-23-8
Chemical Name:
4Hydroxy Tamoxifen
Synonyms
4’-hydroxy Tamoxifen;Tamoxifen Citrate Impurity 18;4'-Hydroxy TaMoxifen (contains up to 10% E isoMer);Tamoxifen Citrate Impurity 13 (4'-Hydroxytamoxifen);4-[(1Z)-1-[[4-[2-(Dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]phenol;Phenol, 4-[(1Z)-1-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]-
CBNumber:
CB41175806
Molecular Formula:
C26H29NO2
Molecular Weight:
387.51
MOL File:
82413-23-8.mol
Modify Date:
2024/10/23 13:36:13
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4Hydroxy Tamoxifen Properties

Melting point 150-153°C
Boiling point 514.4±50.0 °C(Predicted)
Density 1.092±0.06 g/cm3(Predicted)
storage temp. Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility Chloroform (Slightly), Dichloromethane, Methanol (Slightly)
form Solid
pka 10.32±0.15(Predicted)
color White to Off-White
Stability Light Sensitive

4Hydroxy Tamoxifen Chemical Properties,Uses,Production

Description

4’-hydroxy Tamoxifen is one of five main phase I metabolites of tamoxifen , a well-known estrogen receptor antagonist in breast but partial estrogen receptor agonist in endometrium. 4’-hydroxy Tamoxifen is a product of cytochrome P450 (CYP)2D6 and CYP2B6 activity. With the addition of a hydroxyl group, 4’-hydroxy tamoxifen has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. At 10-100 μM, 4’-hydroxy tamoxifen is cytotoxic, in a non-apoptotic manner, to HEC-1B and HEC-1A human endometrial adenocarcinoma cell lines.

Chemical Properties

White Solid

Uses

A metabolite of Tamoxifen (T006000).

4Hydroxy Tamoxifen Preparation Products And Raw materials

Raw materials

Preparation Products

4Hydroxy Tamoxifen Suppliers

Global( 28)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Shenzhen Excellent Biomedical Technology Co.,Ltd. +undefined18318671572 China 1092 58 Inquiry
Shenzhen Excellent Biomedical Technology Co., Ltd. 0755-26050679 18318671572 China 9786 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6213 81 Inquiry
BOC Sciences 1-631-485-4226; 16314854226 United States 12952 65 Inquiry
Shanghai YuZn Pharm. Technology Co.,Ltd. 15921286451; 15921286451 China 5118 58 Inquiry
Hubei Xinyang Medical Technology Co., Ltd 15347293736 15347293736 China 9137 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24642 58 Inquiry
Neobioscience Co., Ltd. 4006-800-892 CHINA 6207 58 Inquiry
Cayman Chemical Company 800-364-9897 China 21645 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Shenzhen Excellent Biomedical Technology Co.,Ltd. 58
Shenzhen Excellent Biomedical Technology Co., Ltd. 58
Cayman Chemical Company 81
BOC Sciences 65
Shanghai YuZn Pharm. Technology Co.,Ltd. 58
Hubei Xinyang Medical Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
Neobioscience Co., Ltd. 58
Cayman Chemical Company 58

82413-23-8(4Hydroxy Tamoxifen)Related Search:

N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) Tamoxifen Impurity 3 4-Benzyloxy β-Hydroxy TaMoxifen TaMoxifen DiMer 1-(4-(2-Dimethylamino)-2-ethoxyphenyl butanone
N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture) Tamoxifen EP Impurity D (E)-4-Alloxycarboxyl Tamoxifen Endoxifen desdimethyltamoxifen
TAMOXIFEN-N-OXIDE Droloxifene (E)-4-Acetoxy Tamoxifen N-Desmethyl Tamoxifen Methanethiosulfonate 2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine
alpha-[4-[2-(dimethylamino)ethoxy]phenyl]-beta-ethyl-alpha-phenylphenethyl alcohol (E)-4-Hydroxy-N-desmethyl Tamoxifen (E/Z)-Tamoxifen
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4-[(1Z)-1-[[4-[2-(Dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]phenol 4'-Hydroxy TaMoxifen (contains up to 10% E isoMer) Phenol, 4-[(1Z)-1-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]- Tamoxifen Citrate Impurity 13 (4'-Hydroxytamoxifen) 4’-hydroxy Tamoxifen Tamoxifen Citrate Impurity 18 82413-23-8 Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals