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1,1,1,3,3,3-Hexafluoro-2-propanol

1,1,1,3,3,3-Hexafluoro-2-propanol Structure
CAS No.
920-66-1
Chemical Name:
1,1,1,3,3,3-Hexafluoro-2-propanol
Synonyms
HFIP;HEXAFLUOROISOPROPANOL;HFP;HFIPA;HEXAFLUORO-2-PROPANOL;(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl formate;1,1,1,3,3,3-HEXAFLUOROISOPROPANOL;N-benzyl-3-methoxy-2-(N-methylacetamido)propanamide;Butter powder;1,1,1,3,3,3-HEXAFLUOROISOPROPYL ALCOHOL
CBNumber:
CB3251829
Molecular Formula:
C3H2F6O
Molecular Weight:
168.04
MOL File:
920-66-1.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
Request For Quotation

1,1,1,3,3,3-Hexafluoro-2-propanol Properties

Melting point −4 °C(lit.)
Boiling point 59 °C(lit.)
Density 1.596 g/mL at 25 °C(lit.)
vapor pressure 269 hPa (30 °C)
refractive index n20/D 1.275(lit.)
Flash point 4,4°C
storage temp. Store below +30°C.
solubility soluble in Chloroform, Ethyl Acetate
pka pK1:9.42 (25°C)
form Solid
color White to yellow
Specific Gravity 1.596
PH 3-4 (H2O)Aqueous solution
Water Solubility 1000 g/L (25 ºC)
λmax 229nm(lit.)
BRN 1841007
Stability Stable. Incompatible with strong acids, strong bases, alkali metals.
InChIKey BYEAHWXPCBROCE-UHFFFAOYSA-N
LogP 1.5 at 25℃
Surface tension 67.1mN/m at 1g/L and 19.8℃
CAS DataBase Reference 920-66-1(CAS DataBase Reference)
NIST Chemistry Reference 2-Propanol, 1,1,1,3,3,3-hexafluoro-(920-66-1)
EPA Substance Registry System 1,1,1,3,3,3-Hexafluoro-2-propanol (920-66-1)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS08
Signal word  Danger
Hazard statements  H314-H361-H373
Precautionary statements  P202-P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  C,Xi
Risk Statements  20/22-34
Safety Statements  26-36/37/39-45-27
RIDADR  UN 2922 8/PG 2
WGK Germany  2
RTECS  UB6450000
F  27
Hazard Note  Corrosive
TSCA  T
HazardClass  8
PackingGroup  II
HS Code  29055910
Toxicity LD50 orally in Rabbit: 1500 mg/kg
NFPA 704
0
3 0

1,1,1,3,3,3-Hexafluoro-2-propanol price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) H0424 1,1,1,3,3,3-Hexafluoropropan-2-ol min. 99.0 % 920-66-1 25G ₹5500 2022-05-26 Buy
TCI Chemicals (India) H0424 1,1,1,3,3,3-Hexafluoropropan-2-ol min. 99.0 % 920-66-1 100G ₹12800 2022-05-26 Buy
TCI Chemicals (India) H0424 1,1,1,3,3,3-Hexafluoropropan-2-ol min. 99.0 % 920-66-1 500G ₹40800 2022-05-26 Buy
ottokemi H 1341 Hexafluoroisopropanol, for spectroscopy 99.5% 920-66-1 50mL ₹20709 2022-05-26 Buy
ottokemi H 1341 Hexafluoroisopropanol, for spectroscopy 99.5% 920-66-1 100mL ₹31509 2022-05-26 Buy
Product number Packaging Price Buy
H0424 25G ₹5500 Buy
H0424 100G ₹12800 Buy
H0424 500G ₹40800 Buy
H 1341 50mL ₹20709 Buy
H 1341 100mL ₹31509 Buy

1,1,1,3,3,3-Hexafluoro-2-propanol Chemical Properties,Uses,Production

Chemical Properties

1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a clear, colorless, oily, combustible liquid. Odor is described as aromatic.

Uses

1,1,1,3,3,3-Hexafluoro-2-propanol effects the native state of proteins, denaturing them as well as stabilizing the α-helical conformation of unfolded proteins and polypeptides.

Definition

ChEBI: An organofluorine compound formed by substitution of all the methyl protons in propan-2-ol by fluorine. It is a metabolite of inhalation anesthetic sevoflurane.

General Description

1,1,1,3,3,3-Hexafluoro-2-propanol is a solution-phase peptide chemistry solvent. This fluorinated polar solvent of high ionizing power facilitates Friedel–Crafts-type reactions, using covalent reagents in the absence of a Lewis acid catalyst. It also enhances the efficiency of rhodium(I)-catalyzed [4+2] intramolecular cycloaddition of ether-tethered alkynyl dienes and [5+2] cycloaddition of alkynyl vinylcyclopropanes. 1,1,1,3,3,3-Hexafluoro-2-propanol clusters catalyzes the epoxidation of cyclooctene and 1-octene with hydrogen peroxide.

Air & Water Reactions

Water soluble.

Reactivity Profile

1,1,1,3,3,3-Hexafluoro-2-propanol is incompatible with acids, acid chlorides and oxidizing agents.

Fire Hazard

1,1,1,3,3,3-Hexafluoro-2-propanol is probably combustible.

Potential Exposure

A specialty solvent for some poly mers; a lavatory reagent.

Shipping

UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.

Purification Methods

Distil it from 3A molecular sieves, retaining the middle fraction. It has been prepared by reduction of hexafluoroacetone in tetrahydrofuran (THF), In this case hexafluoropropanol forms a stable 1:1 complex which distils at 99-100o/760mm (n 25 1.3283), The complex is decomposed by mixing with 20% oleum and distilling in a vacuum, and the distillate is redistilled to give pure hexafluoropropan-2-ol with b 59o/760mm. The 1H NMR shows a doublet at 4.52ppm (JH,H 2Hz). The benzoyl derivative, [10315-85-2] M 272.1, has m 53.9o after crystalllisation from pentane at -50o, and its IR has at 1760cm-1. [Middleton & Lindsey J Am Chem Soc 86 4948 1964, Urry et al. J Org Chem 32 347 1967.] It has very high peptide solubilising properties, alone or with CH2Cl2 [use as a solvent: Narita et al. Bull Chem Soc Jpn 61 281 1988, Biochemistry 29 2639 1990.] It is CORROSIVE, causes severe eye irritation.

Incompatibilities

HFIP is incompatible with acids, acid chlorides, and oxidizing agents.

Waste Disposal

May be incinerated. In accor dance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be dis posed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste contain ing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.

1,1,1,3,3,3-Hexafluoro-2-propanol Preparation Products And Raw materials

Raw materials

Cyanogen bromide 2-Propanol, 1,1,1,2,3,3,3-heptafluoro- 2-(TRIMETHYLSILOXY)PENTAFLUOROPROPENE Methyl 3,3,3-Trifluoro-2-hydroxy-2-trifluoromethylpropionate Chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether
PHENYL FORMATE AMMONIUM TRIFLUOROACETATE Hexachloroacetone Hexafluoroacetone Sodium trifluoroacetate
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Preparation Products

Sevoflurane HEXAFLUOROISOPROPYL TOSYLATE TRIS(1,1,1,3,3,3-HEXAFLUORO-2-PROPYL) PHOSPHITE

1,1,1,3,3,3-Hexafluoro-2-propanol Suppliers

Global( 719)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd. +91-26463395 +91-7926462688 Gujarat, India 1615 58 Inquiry
SRF Limited +91-9810617574 +91-9650533660 Haryana, India 40 58 Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6768 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
Otto Chemie Pvt. Ltd. +91 9820041841 Mumbai, India 5870 58 Inquiry
Sisco Research Laboratories Pvt. Ltd. +91-22-4268 5800 Mumbai, India 4315 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6739 58 Inquiry
Triveni chemicals 08048762458 New Delhi, India 6088 58 Inquiry
Central Drug House(P) Ltd. 91-11-49404040 New Delhi, India 6157 58 Inquiry
Supplier Advantage
Rivashaa Agrotech Biopharma Pvt. Ltd. 58
SRF Limited 58
JSK Chemicals 58
TCI Chemicals (India) Pvt. Ltd. 58
CLEARSYNTH LABS LTD. 58
Otto Chemie Pvt. Ltd. 58
Sisco Research Laboratories Pvt. Ltd. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Triveni chemicals 58
Central Drug House(P) Ltd. 58

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1,1,1,3,3,3-hexafluoro-2-propanolakahfip,hexafluoroisopropanol 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL, 99.8+ % Hexafluoroisopropanol, 99.5% 1,1,1,3,3,3-Hexafluoro-2-propanol, 10% in dichloromethane, for peptide synthesis 1,1,1,3,3,3-Hexafluoro-2-propanol, for peptide synthesis, 99.8% 1,1,1,3,3,3-Hexafluoro-2-propanol, for spectroscopy, 99.9% 1,1,1,3,3,3-Hexafluoro-2-propanol, pure, 99.5+% 1,1,1,3,3,3-Hexafluoro-2-propanolhighpuritygrade HexafluoroisopropanolD2>99% HexafluoroisopropanolD2>99%2x1ml 1,1,1,3,3,3-Hexafluoro-2-propanol99.9% 1,1,1,3,3,3-Hexafluoropropanol-2 Hexafluoroisopropanol,99+% 2-Propanol, 1,1,1,3,3,3-hexafluoro- 1,1,1,3,3,3-Hexafluoroisopropanol 99% 1,1,1,3,3,3-Hexafluoroisopropanol 99.9% 1,1,1,3,3,3-Hexafluoroisoprapanol Hexafluoroisopropanol (1,1,1,3,3,3-Hexafluoro-2-propanol) 1,1,1,3,3,3-Hexafluoro-2-propanol high purity 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL (PEPTIDE GRADE) 1,1,1,3,3,3-Hexafluoropropan-2-ol99% Hexafluoroisopropanol(HFIP)chromatographygrade 1,1,1,3,3,3-Hexafluoro-2-hydroxypropane 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL, 99.5+%, PURE 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL, 99.9%, FOR SPECTROSCOPY 1,1,1,3,3,3-Hexafluoro-2-propanol, pure 1,1,1,3,3,3-Hexafluoro-2-propanol, for spectroscopy 1,1,1,3,3,3-Hexafluoro-2-propanol, for peptide synthesis 1,1,1,3,3,3-Hexafluoro-2-propanol,99.8%,for peptide synthesis 1,1,1,3,3,3-Hexafluoro-2-propanol,for peptidesynthesis,10% in dichloromethane 1,1,1,3,3,3-Hexafluoroisopropyl alcohol≥ 99% (GC) 2,2,2-Trifluoro-1-(trifluoromethyl)ethanol 2H-Hexafluoroisopropanol Bis(trifluoromethyl)methanol Ethanol, 2,2,2-trifluoro-1-(trifluoromethyl)- Hexafluoroisopropylalcohol HEXAFLUORO-2-PROPYLALCOHOL F6IPROH 1,1,1,3,3,3-HEXAFLUOROPROPANOL 1,1,1,3,3,3-HEXAFLUORO PROPAN-2-OL 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL 1,1,1,3,3,3-Hexafluoro-2-propanol ,99.5% 1,1,1,3,3,3-Hexafluoro-2-propanol,HFP, Hexafluoroisopropanol Sevoflurane Related Compound C (0.2 mL) (1,1,1,3,3,3-hexafluoro-2-propanol) 1,1,1,3,3,3-Hexafluoropropan-2-ol 99% 2H-Perfluoropropan-2-ol 99.9% 2H-HEXAFLUORO-2-PROPANOL 1,1,1,3,3,3-Hexafluoro propan-2-ol 99+ % gas chromatography 1,1,1?,3,3-Hexafluoro-2-propanol 1,1,1,3,3,3-Hexafluoropropan-2-ol 99.9% 2H-Hexafluoropropan-2-ol, HFIP 2H-Perfluoropropan-2-ol, HFIP 1,1,1,3,3,3-HEXAFLUORO- 1,1,1,3,3,3-Hexafluoro-2-propanol, pure, 99.5+% 5GR Hexafluoroisopropyl Alcohol HFIP 1,1,1,3,3,3-Hexafluoro-2-propanol, 99%, for analysis 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL FOR SY 2H-Hexafluoropropan-2-ol, HFIP, Hexafluoroisopropanol