Sevoflurane
- CAS No.
- 28523-86-6
- Chemical Name:
- Sevoflurane
- Synonyms
- FLUOROMETHYL 1,1,1,3,3,3-HEXAFLUOROISOPROPYL ETHER;mr6s4;Ultane;R-E 347;Sevoness;347mmzEbg;Sevofrane;Qi Fu Wan;SEVOFLURANE;Seven halothane
- CBNumber:
- CB1440979
- Molecular Formula:
- C4H3F7O
- Molecular Weight:
- 200.05
- MOL File:
- 28523-86-6.mol
- Modify Date:
- 2024/5/31 17:33:32
| Melting point | <25 °C |
|---|---|
| Boiling point | 58°C |
| Density | 1.505 |
| Flash point | 58°C |
| storage temp. | Refrigerator |
| solubility | Slightly soluble in water, miscible with ethanol (96 per cent). |
| Specific Gravity | 1.505 |
| color | Colourless |
| Water Solubility | Slightly miscible with water. |
| Merck | 14,8475 |
| BRN | 2041023 |
| InChIKey | DFEYYRMXOJXZRJ-UHFFFAOYSA-N |
| CAS DataBase Reference | 28523-86-6(CAS DataBase Reference) |
| EPA Substance Registry System | Propane,1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)- (28523-86-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-36/38 | |||||||||
| Safety Statements | 26-36/37/39-36/37-23 | |||||||||
| RIDADR | UN 3334 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KO0737000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29091990 | |||||||||
| NFPA 704 |
|
Sevoflurane price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR3348 | Sevoflurane certified reference material, pharmaceutical secondary standard | 28523-86-6 | 1ML | ₹20426.78 | 2022-06-14 | Buy |
| TCI Chemicals (India) | F0691 | Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether min. 98.0 % | 28523-86-6 | 5G | ₹9500 | 2022-05-26 | Buy |
Sevoflurane Chemical Properties,Uses,Production
Description
Sevoflurane is a rapidly acting, potent inhalation anesthetic with rapid uptake and and elimination. While somewhat less potent than halothane, sevoflurane does not induce arrhythmias and reportedly has no effect on renal function.
Chemical Properties
Clear, colourless, volatile liquid.
Definition
ChEBI: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Biological Functions
Sevoflurane (Ultane) is the most recently introduced inhalation
anesthetic. It has low tissue and blood solubility,
which allows for rapid induction and emergence and
makes it useful for outpatient and ambulatory procedures.
It has the advantage of not being pungent, a characteristic
that permits a smooth inhalation induction,
and is particularly useful in pediatric anesthesia.
Hypotension is produced by sevoflurane as systemic
vasodilation occurs and cardiac output decreases. Since
it does not directly produce tachycardia, it is a useful alternative
to consider in patients with myocardial ischemia.
However, a concern for reflex-induced tachycardia
remains.
Sevoflurane undergoes hepatic biotransformation
(about 3% of the inhaled dose), and it is somewhat degraded
by conventional CO2 absorbents. The degradation
product from the absorbent has been reported to
be nephrotoxic, although the report is controversial and
not substantiated by more recent studies. Sevoflurane’s
actions on skeletal muscle and on vascular regulation
within the CNS are similar to those described for the
other halogenated hydrocarbon anesthetics.
General Description
Sevoflurane is a volatile, nonpungent, nonflammable, andnonexplosive liquid with a boiling point of 58.6°C. Theblood:gas partition coefficient is 0.65, the oil:gas partitioncoefficient is 50, and the MAC is 2.1%. Sevoflurane reactswith desiccated carbon dioxide adsorbents, to produce compounds(A and B) with known toxicity . The typeof CO2 absorbent used, the temperature of the absorbent,and the duration of exposure can influence the degree towhich sevoflurane breaks down. The major breakdownproduct, compound A, pentafluoroisopropenyl fluoromethylether, (PIFE, C4H2F6O) has been studied extensively.Compound A is nephrotoxic in rats and nonhuman primatesand remains a theoretical risk to humans. As discussedpreviously under the stability of inhaled anesthetics,sevoflurane breakdown by CO2 absorbents generates heatand has resulted in sporadic operating room fires.
Clinical Use
Sevoflurane has been shown to cause epileptic changeson EEGs and case reports of seizures during surgery, especiallyin children, have been reported.
Sevoflurane Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | China | 2503 | 58 | Inquiry |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | China | 305 | 58 | Inquiry |
| Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 | China | 295 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21663 | 55 | Inquiry |
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