Isoflurane
- CAS No.
- 26675-46-7
- Chemical Name:
- Isoflurane
- Synonyms
- Forane;Isoflurane266;2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane;1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER;(2R)-2-chloro-2-(difluoroMethoxy)-1,1,1-trifluoroethane;IsofL;Forene;Aerrane;Terrell;Isourane
- CBNumber:
- CB8437691
- Molecular Formula:
- C3H2ClF5O
- Molecular Weight:
- 184.49
- MOL File:
- 26675-46-7.mol
- Modify Date:
- 2024/3/19 15:37:51
| Melting point | 48.5°C |
|---|---|
| Boiling point | 48.5 °C |
| Density | 1.510 g/mL at 25 °C |
| vapor pressure | 238 mmHg ( 20 °C) |
| refractive index | 1.3002 |
| Flash point | 48-49°C |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, miscible with ethanol and trichloroethylene. |
| Specific Gravity | approximate 1.50 |
| color | Colorless to Almost colorless |
| Water Solubility | Soluble in chloroform and ethyl acetate. Not miscible or difficult to mix in water. |
| Merck | 14,5175 |
| BRN | 1852087 |
| Stability | Stable. |
| InChIKey | PIWKPBJCKXDKJR-UHFFFAOYSA-N |
| CAS DataBase Reference | 26675-46-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether(26675-46-7) |
| EPA Substance Registry System | Isoflurane (26675-46-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H336 | |||||||||
| Precautionary statements | P261-P271-P304+P340+P312-P403+P233-P405-P501 | |||||||||
| Hazard Codes | F,T,Xn | |||||||||
| Risk Statements | 36/37/38-67-48/20 | |||||||||
| Safety Statements | 26-36/37/39-24/25 | |||||||||
| RIDADR | UN 3334 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KN6799000 | |||||||||
| Hazard Note | Flammable/Toxic | |||||||||
| HS Code | 2909191800 | |||||||||
| Toxicity | An isomer of enflurane with similar anesthetic properties. Isoflurane has less effect on myocardial function, leaving the cardiovascular system normally responsive to epinephrine or hypercarbia, and it does not cause a marked increase in seizure susceptibility. It was not widely used because of reports that it caused increases in liver neoplasms in mice, but this observation has been challenged and the compound reintroduced. | |||||||||
| NFPA 704 |
|
Isoflurane price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 792632 | Isoflurane | 26675-46-7 | 250MG | ₹4286.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2874 | Isoflurane pharmaceutical secondary standard, certified reference material | 26675-46-7 | 1.2ML | ₹18066.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 792632 | Isoflurane | 26675-46-7 | 1G | ₹14094.15 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C2485 | 1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether min. 98.0 % | 26675-46-7 | 5G | ₹2600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C2485 | 1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether min. 98.0 % | 26675-46-7 | 25G | ₹7000 | 2022-05-26 | Buy |
Isoflurane Chemical Properties,Uses,Production
Chemical Properties
colourless liquid
Uses
Isoflurane is a halogenated ether used for inhalational anesthesia. Recent studies suggest that there might be a relationship between administration of isoflurane and postoperative cognitive dysfunct ion (POCD).
Biological Functions
Isoflurane (Forane) is a structural isomer of enflurane
and produces similar pharmacological properties: some
analgesia, some neuromuscular blockade, and depressed
respiration. In contrast, however, isoflurane is considered
a particularly safe anesthetic in patients with ischemic
heart disease, since cardiac output is maintained,
the coronary arteries are dilated, and the myocardium
does not appear to be sensitized to the effects of catecholamines.
Also, blood pressure falls as a result of vasodilation,
which preserves tissue blood flow. Isoflurane
causes transient and mild tachycardia by direct sympathetic
stimulation; this is particularly important in the
management of patients with myocardial ischemia.
Unlike enflurane, isoflurane does not produce a
seizurelike EEG pattern. Furthermore, the metabolic
transformation of isoflurane is only one-tenth that of
enflurane, so fluoride production is quite low. Among
the halogenated hydrocarbons, isoflurane is one of the
most popular, since it preserves cardiovascular stability
and causes a low incidence of untoward effects.
General Description
Isoflurane is a volatile liquid (bp＝48.5°C) with an MAC of1.15, a blood:gas partition coefficient of 1.43 and high solubilityin fat. Isoflurane is a structural isomer of enflurane. Itis a known respiratory irritant, but less so than desflurane.Approximately 0.2% of the administered drug undergoesmetabolism, the rest is exhaled unchanged. The metabolismof isoflurane yields low levels of the nephrotoxic fluoride ionas well as a potentially hepatotoxic trifluoroacetylating compound). The relatively low concentrations ofthese compounds have resulted in very low risks of hepatotoxicityand nephrotoxicity. There have been no reports ofseizures caused by isoflurane and only transient increases inheart rate have been reported.
Clinical Use
Isoflurane was introduced in the United States in 1981 and is a potent anesthetic agent with many similarities to its isomer enflurane (potent, nonflammable, and intermediate blood solubility). It does produce significantly fewer cardiovascular effects than enflurane, however, and it can be used safely with epinephrine without as great a concern for arrhythmia production. Isoflurane has a more pungent odor than halothane and, thus, can cause irritation to the throat and respiratory tract, triggering coughing and laryngospasm. To overcome this problem, it often is supplemented with intravenous agents. Less than 0.2% of an administered dose is metabolized, mostly to fluoride and trifluoroacetic acid. Some minimal potential for hepatotoxicity is associated with a trifluoroacetyl halide metabolite.
Isoflurane Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| PIRAMAL ENTERPRISES LTD | +91-22-3802 3000/4000 | New Delhi, India | 45 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Shree Sai Healthcare | 08047620861 | Delhi, India | 6 | 58 | Inquiry |
| Vitus Global Inc | 91-11-40516279 | Delhi, India | 91 | 58 | Inquiry |
| Sudarshan Specaility Chemsolve P Ltd | -42505609 | Maharashtra, India | 12 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMSWORTH | 30 |
| PIRAMAL ENTERPRISES LTD | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Shree Sai Healthcare | 58 |
| Vitus Global Inc | 58 |
| Sudarshan Specaility Chemsolve P Ltd | 58 |
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- Feb 18，2022
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