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Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate

Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate Structure
CAS No.
136285-65-9
Chemical Name:
Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate
Synonyms
Azilsartan impurity Z;Azilsartan Impurity 113;Candesartan Impurity 16;Nicotinamide Impurity 62;Candesartan ester intermediate C3;2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate;Ethyl 2-[(t-butoxycarbonyl)amino]-3-nitrobenzoate;Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate;Ethyl-2-(tertiary butoxy carbonyl aMino)-3-nitro benzoate;ETHYL-2-T-BUTOXY-2-CARBOXYLAMINO-3-NITROBENZOATE 136285-65-9
CBNumber:
CB32537307
Molecular Formula:
C14H18N2O6
Molecular Weight:
310.3
MOL File:
136285-65-9.mol
Modify Date:
2024/5/9 13:11:54
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Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate Properties

Boiling point 390.8±32.0 °C(Predicted)
Density 1.268
storage temp. Sealed in dry,Room Temperature
pka 12.00±0.70(Predicted)

Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate Chemical Properties,Uses,Production

Acquired resistance

A mixture of ethyl 2-carboxy-3-nitrobenzoate(23.9 g) and thionyl chloride (12 ml) in benzene (150 ml) was heated under reflux for 3 hours. The reaction mixture was concentrated to dryness. The resultant acid chloride (26 g, quantitative) was dissolved in methylene chloride (20 ml). The solution was added dropwise to a mixture of sodium azide (9.75 g) in dimethylformamide(DMF) (20 ml) while stirring vigorously. The reaction mixture was poured into ether-hexane (3:1, 200 ml) and water (250 ml) to separate into two layers. The organic layer was washed with water and then dried, followed by evaporation of the solvent. The residue was dissolved in t-butanol (200 ml), and the solution was heated gradually with stirring, followed by heating under reflux for 2 hours. The reaction mixture was concentrated in vacuo to give an oily product Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate (30 g).

Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate Preparation Products And Raw materials

Raw materials

2-CARBOXY-3-ETHYL NITROBENZOATE

Preparation Products

ethyl 2-amino-3-nitro-benzoate

Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate Suppliers

Global( 111)Suppliers
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career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Univar Solutions(China) Co., Ltd. +8615902132654 China 654 58 Inquiry
Neostar United (Changzhou) Industrial Co., Ltd. +86-519-519-85557386 China 12210 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23556 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
Hangzhou Benoy Chemical Co., Ltd +8617342059697 China 315 58 Inquiry
Hebei Dangtong Import and export Co LTD +8615632927689 China 984 58 Inquiry
Supplier Advantage
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
Univar Solutions(China) Co., Ltd. 58
Neostar United (Changzhou) Industrial Co., Ltd. 58
ANHUI WITOP BIOTECH CO., LTD 58
AFINE CHEMICALS LIMITED 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Hangzhou Benoy Chemical Co., Ltd 58
Hebei Dangtong Import and export Co LTD 58

136285-65-9(Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate)Related Search:

Trityl candesartan cilexetil Candesartan cilexetil Trityl candesartan Candesartan Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate
2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]amino]-3-nitro-benzoic acid ethyl ester BENZOIC ACID, 2-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-3-NITRO-METHYL ESTER Methyl 2-ethoxybenzimidazole-7-carboxylate Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER
Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate Ethyl-2-Ethoxy-1-[[(2'-(1h-Tetrazol-5-Yl)Biphenyl-4-Yl)Methyl]Benzimidazole]-7-Carboxylate
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2-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-nitrobenzoic acid ethyl ester Ethyl-2-(tertiary butoxy carbonyl aMino)-3-nitro benzoate 2-[1.1-diMethyl ethyl ethoxy carbonyl]aMino-3-nitro benzoic acid Ethyl Ester ( C3 ) Ethyl 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate Ethyl 2-[(t-butoxycarbonyl)amino]-3-nitrobenzoate Candesartan ester intermediate C3 Benzoicacid, 2-[[(1, 1-diMethylethoxy)carbonyl]aMino]-3-nitro-, ethyl ester Ethyl 2-((((2-methylpentan-2-yl)oxy)carbonyl)amino)-3-nitrobenzoate 2-[1.1-dimethyl ethyl ethoxy carbonyl]amino-3-nitro benzoic acid ethyl ester Azilsartan impurity Z ETHYL-2-T-BUTOXY-2-CARBOXYLAMINO-3-NITROBENZOATE 136285-65-9 2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate Ethyl 2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-nitrobenzoate Azilsartan Impurity 113 Nicotinamide Impurity 62 Candesartan Impurity 16 136285-65-9