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Candesartan

CAS No.: 139481-59-7

Chemical Name:: Candesartan

Synonyms: Atacend;CV-11974;CILEXITIL;CANDESARTAN;tandishatan;Candesartan M1;Candesartan 98%;Candesartan Base;Candesartan (C8);Candesartan (Atacand)

CBNumber:: CB0209324

Molecular Formula:: C24H20N6O3

Molecular Weight:: 440.45

MOL File:: 139481-59-7.mol

Modify Date:: 2024/5/10 17:26:08

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Candesartan Properties

Melting point	183-185°C
Boiling point	754.8±70.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
RTECS	DD6671000
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Soluble in DMSO (up to 40 mg/ml)
form	solid
pka	2.06±0.10(Predicted)
color	White
Water Solubility	Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference	139481-59-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H312-H315-H319-H332-H335
Precautionary statements	P261-P280-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26-36-60-36/37-9
HS Code	29419000

Candesartan Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Uses

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

Definition

ChEBI: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin eceptor antagonist used for the treatment of hypertension.

General Description

Candesartan, (+)-1-[[(cyclohexyloxy)carbonyl]-oxy]ethyl 2- ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate(Atacand), like losartan, possesses the acidic tetrazole system,which most likely plays a role in binding to the angiotensin IIreceptor similarly to the acidic groups of angiotensin II. Also,the imidazole system has been replaced with a benzimidazolepossessing an ester at position. This ester must be hydrolyzedto the free acid. Fortunately, this conversion takesplace fairly easily because of the carbonate in the ester sidechain. This facilitates hydrolysis of the ester so much thatconversion to the free acid takes place during absorption fromthe gastrointestinal tract.

Candesartan Preparation Products And Raw materials

Raw materials

Sodium azide Mineral oil Potassium carbonate Trifluoroacetic acid tert-Butanol

3-Nitrophthalic acid Benzyl bromide Thionyl chloride

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Preparation Products

Candesartan Suppliers

Global( 498)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ALMELO PRIVATE LIMITED	+91-9100991345 +91-8500807769	Telangana, India	114	58	Inquiry
Chemicea Pharmaceuticals Pvt Ltd	+91-918482849343 +91-8482849343	Mumbai, India	461	58	Inquiry
CLEANCHEM LABORATORIES LLP	+91-9951015911 +91-9951015911	Mumbai, India	281	58	Inquiry
GLP Pharma Standards	+91 9866074638	Hyderabad, India	1644	58	Inquiry
CHEMAZON LABORATORIES	+91 9848551964	Hyderabad, India	1320	58	Inquiry
Lupin Ltd	+91-8019896181 +91-8019896181	Maharashtra, India	93	58	Inquiry
Lakshmi Farmachem	+91-9948795885 +91-9550886476	Telangana, India	407	58	Inquiry
Gensynth Laboratories Pvt. Ltd	+91-9502663206 +91-9502663206	Hyderabad, India	22	58	Inquiry
Besil Chem LLP	+91-7760252666 +91-9880731835	Bangalore, India	163	58	Inquiry
Lavybens Pharma	+91-8790466757 +91-8790466756	Telangana, India	80	58	Inquiry

Supplier	Advantage
ALMELO PRIVATE LIMITED	58
Chemicea Pharmaceuticals Pvt Ltd	58
CLEANCHEM LABORATORIES LLP	58
GLP Pharma Standards	58
CHEMAZON LABORATORIES	58
Lupin Ltd	58
Lakshmi Farmachem	58
Gensynth Laboratories Pvt. Ltd	58
Besil Chem LLP	58
Lavybens Pharma	58

Candesartan Spectrum

Candesartan(139481-59-7)¹HNMR

139481-59-7(Candesartan)Related Search:

METSULFURON METHYL Methyl salicylate Kresoxim-methyl Ethoxyquin PHENYL VALERATE

Candesartan Cilexetil DIETHOXYMETHANE Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate

Benzimidazole Tribenuron methyl Thiophanate-methyl TRITYL CANDESARTAN 4-Ethoxyphenol

Methyl Telmisartan Irbesartan

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1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-ethoxy-1H-benzo[d]iMidazole-7-carboxylic acid 2-ethoxy-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]-3h-benzoimidazole-4-carboxylic acid 3-[[2'-(1H-Tetrazol-5-yl)biphenyl-4-yl]Methyl]-2-ethoxy-3H-benziMidazole-4- carboxylic Acid Candesartan M1 2-ETHOXY1-2(1H-TETRAZOL-5YL)1,1-BIPHENYL)-4-YL)-4-YL)METHYL)1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID Candesartan Cilexetil EP IMpurity G 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxy Candesartan Base 2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL]METHYL]-1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID Candesartan[CandesartanCilexetilIntermediates] Candesartan ( For Candesartan Cilexetil ) CANDESARTAN CV-11974 CILEXITIL 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid, CV-11974 2-Ethoxy-1-[2'-(1-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl-methyl]benzimidazole-7-carboxylicacidcyclohexyl-1-chloroethylcarbonate 2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] 2-Ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl] Atacend 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazol-7-carboxylic acid (±)-2-Ethoxy-1-[[2’-(1H-tetrazol-5-y1)[1，l'-biphenyl]-4-y1]methyl]-1H-benzimidazole-7-earboxylic acid 3-(2'-Cyano-biphenyl-4-ylMethyl)-2-ethoxy-3H-benzoiMidazole-4-carboxylic acid Me 2-ethoxy-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)-1H-1,3-benzodiazole-7-carboxylic acid Candesartan (Atacand) Candesartan 98% Candesartan (Candesartan Cilexetil impurity G) Candesartan Solution, 1000ppm Candesartan Cilexetil Impurity 7(EP Impurity G) Candesartan Solution, 100ppm tandishatan Candesartan Cilexetil EP Impurity G(Candesartan) 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid 2-Ethoxy-1-[[(2′-(1Htetrazol-5-Yl)Biphenyl-4-Yl-) Methyl]Benzimidazole-7-Carboxylic Acid Candesartan (C8) 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid Candesartan USP/EP/BP Cesartan intermediates Candesartan EP Impurity G Candesartan Cilexetil EP Impurity G (Candesartan Acid) Candesartan Impurity -G Candesartan Cilexetil EP Impurity G High Quality Intermediates Candesartan CAS: 139481-59-7 Candesartan (CV 11974) candesartan cilexetil impurity1364 CandesartanQ: What is Candesartan Q: What is the CAS Number of Candesartan Q: What is the storage condition of Candesartan Q: What are the applications of Candesartan Candesartan Cilexetil Related Compound G (1-{[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-2-ethoxybe (1087870) Candesartan Cilexetil USP Related Compound G Candesartan Cilexetil Impurity 7(Candesartan Cilexetil EP Impurity G) 3-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-3H-benzo[d]imidazole-4-carboxylic acid [CS-VII (Acid) Candesartan Impurity-G 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-Biphenyl]-4-yl)Methyl)-2-Ethoxy-1H-Benzo[d]iMidazole-7-Carboxylicacid 139481-59-7 C24H20N6O3 Isotope Pharmaceutical raw material Aromatics