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3-Nitrophthalic acid

3-Nitrophthalic acid Structure
CAS No.
603-11-2
Chemical Name:
3-Nitrophthalic acid
Synonyms
3-NPA;o-Nitrophthalic acid;Pomalidomide Impurity 8;3-nitro-1,2-benzenedicarboxylic acid;NSC 3120;AKOS B028734;3-nitrophthalic;3-nitro-phthalate;RARECHEM AL BO 0803;m-Nitrophthalic acid
CBNumber:
CB5323089
Molecular Formula:
C8H5NO6
Molecular Weight:
211.13
MOL File:
603-11-2.mol
MSDS File:
SDS
Modify Date:
2024/7/26 17:49:17

3-Nitrophthalic acid Properties

Melting point 210 °C (dec.) (lit.)
Boiling point 350.79°C (rough estimate)
Density 1.6342 (rough estimate)
vapor density 7.3 (vs air)
refractive index 1.5282 (estimate)
storage temp. Store below +30°C.
solubility water: soluble5%, clear to slightly hazy, colorless to faint yellow or tan
form Powder
pka pK1:1.88 (25°C)
color Off-white to light yellow
Water Solubility 20 g/L (25 ºC)
Decomposition 216 °C
BRN 2054269
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey KFIRODWJCYBBHY-UHFFFAOYSA-N
CAS DataBase Reference 603-11-2(CAS DataBase Reference)
NIST Chemistry Reference 3-Nitrophthalic acid(603-11-2)
EPA Substance Registry System 3-Nitrophthalic acid (603-11-2)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS07
Signal word  Danger
Hazard statements  H315-H318-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38-41
Safety Statements  26-36/39-37/39-36
WGK Germany  3
Hazard Note  Irritant
TSCA  Yes
HS Code  29173980
NFPA 704
1
2 0

3-Nitrophthalic acid price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 369306 3-Nitrophthalic acid 95% 603-11-2 100G ₹4405.78 2022-06-14 Buy
Sigma-Aldrich(India) 137820 3-Nitrophthalic acid 99% 603-11-2 100G ₹9612.6 2022-06-14 Buy
TCI Chemicals (India) N0243 3-Nitrophthalic Acid 603-11-2 25G ₹1800 2022-05-26 Buy
TCI Chemicals (India) N0243 3-Nitrophthalic Acid 603-11-2 500G ₹8100 2022-05-26 Buy
ottokemi N 1928 3-Nitrophthalic acid 98% 603-11-2 100gm ₹792 2022-05-26 Buy
Product number Packaging Price Buy
369306 100G ₹4405.78 Buy
137820 100G ₹9612.6 Buy
N0243 25G ₹1800 Buy
N0243 500G ₹8100 Buy
N 1928 100gm ₹792 Buy

3-Nitrophthalic acid Chemical Properties,Uses,Production

Chemical Properties

Pale yellow crystals. soluble in hot water, methanol, ethanol, slightly soluble in ether, insoluble in chloroform, carbon tetrachloride, carbon disulfide, benzene.

Uses

3-Nitrophthalic Acid is a useful chemical in organic synthesis. It is also an impurity of Apremilast.

Preparation

Phthalic anhydride was added to concentrated sulfuric acid, stirring under the passage of water vapor heating to 80 °C, fuming nitric acid was added dropwise, the reaction temperature to maintain 100-110°C, add the end of the heat above 110°C for 2h, placed in the overnight pour into the water, and filtered. The filter cake was recrystallized with water to obtain 3-Nitrophthalic acid. Yield of about 30%.

General Description

3-Nitrophthalic acid is a degradation product of isoxaben herbicide. It acts as ligand and forms rare-earth complexes.

Safety Profile

A preparative hazard. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise 3-nitrophthalic acid from hot water (1.5mL/g). Dry it in air. The amide has m 201o (from EtOH). [Beilstein 9 H 823, 9 IV 3275.]

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3-Nitrophthalic acid 96% 3-nitrophthalic m-Nitrophthalic acid Phthalic acid, 3-nitro- LABOTEST-BB LT01689746 AKOS B028734 m-Nitro Phthalic Acid 3-Nitro Phthalic Acid 3-NitrophthalicAcid,>99% 3-NITROBENZENE-1,2-DICARBOXYLIC ACID 3-NITROPHTHALIC ACID 3-NITROPHTHALIC ACID pure 3 NITRO PHTHALLIC ACID 3-Nitrophthalic acid,95% 3-Nitrophthalic acid ,98% 3-Nitrophthalic acid, 95% 500GR NSC 3120 3-Nitrobenzene-1,2-dicarboxylic acid, 2,3-Dicarboxynitrobenzene 3-nitro-phthalate 3-Nitrophthalic Acid, 97+% Pomalidomide Impurity 2 RARECHEM AL BO 0803 1,2-Benzenedicarboxylic acid, 3-nitro- 3-nitro-2-benzenedicarboxylicacid 3-Nitro-1,2-benzenedicarboxylic acid 3-NPA 3-Nitrophthalic acid ISO 9001:2015 REACH Apremilast Impurity 86 3-Nitrophthalic acid(3-NPA) 3-NPA 3-nitro-1,2-benzenedicarboxylic acid o-Nitrophthalic acid Pomalidomide Impurity 8 RSSYY(Lurasidone Hydrochloride)-9 3-NITROPHTHALIC ACID >98% On Req 603-11-2 603-111-2 603-11-8 603-11-3 O2NC6H3COOH2 C8H5NO6 C8H5O6N O2NC6H312CO2H2 Organic Building Blocks Building Blocks C8 Carboxylic Acids Carbonyl Compounds intermediate Aromatics C8 Carbonyl Compounds Carboxylic Acids Organic acids Dyes intermediates Phthalic Acids, Esters and Derivatives Organics 1 603-11-2