3-Nitrophthalic acid
![3-Nitrophthalic acid Structure](CAS/GIF/603-11-2.gif)
- CAS No.
- 603-11-2
- Chemical Name:
- 3-Nitrophthalic acid
- Synonyms
- 3-NPA;o-Nitrophthalic acid;Pomalidomide Impurity 8;3-nitro-1,2-benzenedicarboxylic acid;NSC 3120;AKOS B028734;3-nitrophthalic;3-nitro-phthalate;RARECHEM AL BO 0803;m-Nitrophthalic acid
- CBNumber:
- CB5323089
- Molecular Formula:
- C8H5NO6
- Molecular Weight:
- 211.13
- MOL File:
- 603-11-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/26 17:49:17
Melting point | 210 °C (dec.) (lit.) |
---|---|
Boiling point | 350.79°C (rough estimate) |
Density | 1.6342 (rough estimate) |
vapor density | 7.3 (vs air) |
refractive index | 1.5282 (estimate) |
storage temp. | Store below +30°C. |
solubility | water: soluble5%, clear to slightly hazy, colorless to faint yellow or tan |
form | Powder |
pka | pK1:1.88 (25°C) |
color | Off-white to light yellow |
Water Solubility | 20 g/L (25 ºC) |
Decomposition | 216 °C |
BRN | 2054269 |
Stability | Stable. Incompatible with strong oxidizing agents. |
InChIKey | KFIRODWJCYBBHY-UHFFFAOYSA-N |
CAS DataBase Reference | 603-11-2(CAS DataBase Reference) |
NIST Chemistry Reference | 3-Nitrophthalic acid(603-11-2) |
EPA Substance Registry System | 3-Nitrophthalic acid (603-11-2) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS05,GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H315-H318-H335 | |||||||||
Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38-41 | |||||||||
Safety Statements | 26-36/39-37/39-36 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Irritant | |||||||||
TSCA | Yes | |||||||||
HS Code | 29173980 | |||||||||
NFPA 704 |
|
3-Nitrophthalic acid price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 369306 | 3-Nitrophthalic acid 95% | 603-11-2 | 100G | ₹4405.78 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 137820 | 3-Nitrophthalic acid 99% | 603-11-2 | 100G | ₹9612.6 | 2022-06-14 | Buy |
TCI Chemicals (India) | N0243 | 3-Nitrophthalic Acid | 603-11-2 | 25G | ₹1800 | 2022-05-26 | Buy |
TCI Chemicals (India) | N0243 | 3-Nitrophthalic Acid | 603-11-2 | 500G | ₹8100 | 2022-05-26 | Buy |
ottokemi | N 1928 | 3-Nitrophthalic acid 98% | 603-11-2 | 100gm | ₹792 | 2022-05-26 | Buy |
3-Nitrophthalic acid Chemical Properties,Uses,Production
Chemical Properties
Pale yellow crystals. soluble in hot water, methanol, ethanol, slightly soluble in ether, insoluble in chloroform, carbon tetrachloride, carbon disulfide, benzene.
Uses
3-Nitrophthalic Acid is a useful chemical in organic synthesis. It is also an impurity of Apremilast.
Preparation
Phthalic anhydride was added to concentrated sulfuric acid, stirring under the passage of water vapor heating to 80 °C, fuming nitric acid was added dropwise, the reaction temperature to maintain 100-110°C, add the end of the heat above 110°C for 2h, placed in the overnight pour into the water, and filtered. The filter cake was recrystallized with water to obtain 3-Nitrophthalic acid. Yield of about 30%.
General Description
3-Nitrophthalic acid is a degradation product of isoxaben herbicide. It acts as ligand and forms rare-earth complexes.
Safety Profile
A preparative hazard. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Crystallise 3-nitrophthalic acid from hot water (1.5mL/g). Dry it in air. The amide has m 201o (from EtOH). [Beilstein 9 H 823, 9 IV 3275.]
3-Nitrophthalic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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RP Industries | +91-9700187008 +91-9700187008 | Gujarat, India | 58 | 58 | Inquiry |
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GRINDLAYS PHARMACEUTICALS PRIVATE LIMITED | +91-91-22-25278801 +91-2225278801 | Mumbai, India | 83 | 58 | Inquiry |
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DL INTRACHEM | +91-9375014678 +91-9099014678 | Gujarat, India | 55 | 58 | Inquiry |
Supplier | Advantage |
---|---|
RP Industries | 58 |
Danopharm Chemicals Pvt.Ltd. | 58 |
GRINDLAYS PHARMACEUTICALS PRIVATE LIMITED | 58 |
CLEANCHEM LABORATORIES LLP | 58 |
SNECOFRi Pvt Ltd | 58 |
VGS SYNTHESIS PRIVATE LIMITED | 58 |
JSK Chemicals | 58 |
CNS CHEMICALS | 58 |
Alchem Synthon Pvt Ltd | 58 |
DL INTRACHEM | 58 |
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