1-Methyl-3-nitrophthalate

1-Methyl-3-nitrophthalate Structure
CAS No.
21606-04-2
Chemical Name:
1-Methyl-3-nitrophthalate
Synonyms
)-6-nitrobenzoic Acid;Apremilast Impurity 85;1-Methyl-3-nitrophthalate;Sitagliptin Impurity 1-d4;METHYL2-CARBOXY-3-NITROBENZOATE;3-nitro-2-Carboxyl methyl benzoate;Methyl 3-nitro-2-carboxyl benzoate;2-methoxycarbonyl-6-nitrobenzoicaci;3-Nitro-phthalic acid 1-Methyl ester;2-Methoxyxcarbonyl-6-nitrobenzoic acid
CBNumber:
CB3671043
Molecular Formula:
C9H7NO6
Molecular Weight:
225.15
MOL File:
21606-04-2.mol
Modify Date:
2023/6/8 17:06:38

1-Methyl-3-nitrophthalate Properties

Melting point 160.0 to 164.0 °C
Boiling point 409.2±35.0 °C(Predicted)
Density 1.484±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility soluble in Acetone, Dichloromethane, Ethyl Acetate, Methanol
form Solid:particulate/powder
pka 1.87±0.30(Predicted)
color White to Almost white
CAS DataBase Reference 21606-04-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code  2917.39.7000
NFPA 704
0
2 0

1-Methyl-3-nitrophthalate price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) M2795 2-(Methoxycarbonyl)-6-nitrobenzoic Acid min. 98.0 % 21606-04-2 5G ₹4100 2022-05-26 Buy
TCI Chemicals (India) M2795 2-(Methoxycarbonyl)-6-nitrobenzoic Acid min. 98.0 % 21606-04-2 25G ₹14800 2022-05-26 Buy
Product number Packaging Price Buy
M2795 5G ₹4100 Buy
M2795 25G ₹14800 Buy

1-Methyl-3-nitrophthalate Chemical Properties,Uses,Production

Chemical Properties

light yellow crystalline powder

Uses

Methyl 3-Nitrophthalate is an intermediate in the synthesis of (αS)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]-N-[(1S)-1-phenylethyl]-benzenemethanamine which is an impurity of Apremilast (A729700), which is an oral phosphodiesterase 4 inhibitor used for treating psoriatic arthritis.

1-Methyl-3-nitrophthalate Preparation Products And Raw materials

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3-nitro-2-Carboxyl methyl benzoate 1-Methyl-3-nitrophthalate 3-Nitro-1,2-Benzenedi-Carboxylic Acid Monomethyl Ester 3-Nitro-1,2-benzenedicarboxylic acid 1-methyl ester METHYL2-CARBOXY-3-NITROBENZOATE Methyl 3-nitro-2-carboxyl benzoate 3-Nitro-phthalic acid 1-Methyl ester 2-(Methoxycarbonyl)-6-nitrobenzoic acid 2-NITRO-6-METHOXYCARBONYL BENZOIC ACID 1,2-BENZENEDICARBOXYLIC ACID, 3-NITRO-1-METHYL ESTER 2-Methoxyxcarbonyl-6-nitrobenzoic acid 3 - nitro - 2 - carboxyl Methyl benzoic acid )-6-nitrobenzoic Acid Apremilast Impurity 85 1-Methyl 3-nitro-1,2-benzenedicarboxylate 2-methoxycarbonyl-6-nitrobenzoicaci Sitagliptin Impurity 1-d4 21606-04-2