(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
![(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Structure](CAS/20180713/GIF/608141-43-1.gif)
- CAS No.
- 608141-43-1
- Chemical Name:
- (S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt
- Synonyms
- Apremilast Impurity 62;RSSYY(Lurasidone Hydrochloride)-15;(2S)-2-acetamido-4-methylpentanoate;Apremilast Impurity 2 N-Acetyl-L-Leucine Salt;Apremilast Impurity 4 N-Acetyl-L-Leucine Salt;Apremilast Impurity 35 N-acetyl-L-leucine Salt;Apremilast Impurity 21 N-Acetyl-L-Leucine Salt;Apremilast Impurity 55(N-Acetyl-L-leucine Salt);(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin...;[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]azanium
- CBNumber:
- CB12707852
- Molecular Formula:
- C20H34N2O7S
- Molecular Weight:
- 446.56
- MOL File:
- 608141-43-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/17 13:33:44
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
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CAS DataBase Reference | 608141-43-1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Chemical Properties,Uses,Production
Synthesis
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt is prepared by the reaction of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine and N-Acetyl-L-leucine. The specific synthesis steps are as follows:
A 3 L 3-necked round bottom flask was equipped with a mechanical stirrer, thermometer, and condenser and charged with 2-(3 -ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine (137.0 g, 500 mmol), N-acetyl-L-leucine (52 g, 300 mmol), and methanol (1.0 L). The stirred slurry was heated to reflux for 1 hour. The stirred mixture was allowed to cool to ambient temperature and stirring was continued for another 3 hours at ambient temperature. The slurry was filtered andwashed with methanol (250 mL). The solid was air-dried and then dried in vacuo at ambient temperature to a constant weight, giving 109.5 g (98percent yield) of the crude product (85.8percent ee). The crude solid (55.0 g) and methanol (440 mL) were brought to reflux for 1 hour, cooled to room temperature and stirred for an additional 3 hours at ambient temperature. The slurry was filtered and the filter cake was washed with methanol (200 mL). The solid was air-dried and then dried invacuo at 30°C. to a constant weight, yielding 49.6 g (90percent recovery) of(S)-2-(3-ethoxy-4-methoxyphenyl)- 1 -(methylsulphonyl)-eth-2-ylamine-N-acety l-L-leucine salt (98.4percent ee). ChiralHPLC (1/99 EtOH/20 mM KH2PO4 pH 7.0, Ultron Chiral ES-OVS from Agilent Technologies,150 mm4.6 mm, 0.5 mL/min., 240 nm): 18.4 mm (S-isomer, 99.2percent), 25.5 mm (R-isomer,0.8percent).
(S)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine N-acetyl-L-leucine salt Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
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JLS Laboratories Pvt Limited | +91 8790545679 | Hyderabad, India | 62 | 58 | Inquiry |
BNR LABORATORIES | +91-9490673489 +91-9490673489 | Telangana, India | 25 | 58 | Inquiry |
RS LIFE SCIENCES | +91-9963585741 +91-9963585741 | Hyderabad, India | 32 | 58 | Inquiry |
Aventus Labs | +91-7021872517 +91-9324342304 | Maharashtra, India | 168 | 58 | Inquiry |
Glenfin Chemicals Pvt Ltd | +91-9923430013 +91-9323802458 | Maharashtra, India | 63 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
Supplier | Advantage |
---|---|
JLS Laboratories Pvt Limited | 58 |
BNR LABORATORIES | 58 |
RS LIFE SCIENCES | 58 |
Aventus Labs | 58 |
Glenfin Chemicals Pvt Ltd | 58 |
CLEARSYNTH LABS LTD. | 58 |
A.J Chemicals | 58 |
Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
Pharma Affiliates | 58 |
SynZeal Research Pvt Ltd | 58 |
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