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3-Nitrophthalic anhydride

3-Nitrophthalic anhydride Structure
CAS No.
641-70-3
Chemical Name:
3-Nitrophthalic anhydride
Synonyms
1,3-Isobenzofurandione, 4-nitro-;3-Nitrophthalic Acid Anhydride;4-NITRO-ISOBENZOFURAN-1,3-DIONE;NSC 4134;NSC 27006;3-NitrophthaL;Pomalidomide INT;Apremilast Impurity 90;Pomalidomide Impurity 36;3-NITROPHTHALIC ANHYDRIDE
CBNumber:
CB8116378
Molecular Formula:
C8H3NO5
Molecular Weight:
193.11
MOL File:
641-70-3.mol
MSDS File:
SDS
Modify Date:
2024/8/24 19:19:26

3-Nitrophthalic anhydride Properties

Melting point 163-165 °C (lit.)
Boiling point 329.3°C (rough estimate)
Density 1.6392 (rough estimate)
refractive index 1.4700 (estimate)
storage temp. Store below +30°C.
form Crystalline Powder
color Beige to yellow
Water Solubility MAY DECOMPOSE
Sensitive Moisture Sensitive
BRN 179963
CAS DataBase Reference 641-70-3(CAS DataBase Reference)
NIST Chemistry Reference 3-Nitrophthalic anhydride(641-70-3)
EPA Substance Registry System 1,3-Isobenzofurandione, 4-nitro- (641-70-3)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
10-21
TSCA  Yes
HS Code  29173980
NFPA 704
1
2 1

3-Nitrophthalic anhydride price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 8.20903 3-Nitrophthalic anhydride for synthesis 641-70-3 25G ₹4440 2022-06-14 Buy
Sigma-Aldrich(India) 8.20903 3-Nitrophthalic anhydride for synthesis 641-70-3 100G ₹10910 2022-06-14 Buy
Sigma-Aldrich 156884 3-Nitrophthalic anhydride 98% 641-70-3 5G ₹3832.05 2022-06-14 Buy
Sigma-Aldrich(India) 156884 3-Nitrophthalic anhydride 98% 641-70-3 5G ₹3832.05 2022-06-14 Buy
Sigma-Aldrich 156884 3-Nitrophthalic anhydride 98% 641-70-3 25G ₹9114.65 2022-06-14 Buy
Product number Packaging Price Buy
8.20903 25G ₹4440 Buy
8.20903 100G ₹10910 Buy
156884 5G ₹3832.05 Buy
156884 5G ₹3832.05 Buy
156884 25G ₹9114.65 Buy

3-Nitrophthalic anhydride Chemical Properties,Uses,Production

Chemical Properties

Beige to yellow crystalline powder

Uses

An intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472). Reactions with aminoquinazolinones yield phthalimidoquinazolinones.

Preparation

3-Nitrophthalic anhydride can be prepared by heating 3-nitrophthalic acid under various conditions and by the action of acetic anhydride, essentially as in the procedure described. The direct nitration of phthalic anhydride yields 3-nitrophthalic anhydride together with the isomeric 4-nitro compound.

Purification Methods

Crystallise it from *C6H6, *C6H6/pet ether, Me2CO, AcOH, or Ac2O (m 164-165o). Dry it at 100o. [Beilstein 17 III/IV 6149, 17/11 V 266.]

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