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Vilanterol Trifenatate

CAS No.: 503070-58-4

Chemical Name:: Vilanterol Trifenatate

Synonyms: vilanterol trifenatate;Vilanterol Trifenate;Vilanterol triphenylacetate;GW642444M;GW 642444M;GW-642444M;GW642444M Trifenate;GW642444 (trifenatate);Vilanterol Trifenatate (API);GW642444M; GW 642444M; GW-642444M

CBNumber:: CB32563287

Molecular Formula:: C44H49Cl2NO7

Molecular Weight:: 774.78

MOL File:: 503070-58-4.mol

MSDS File:: SDS

Modify Date:: 2024/3/11 17:00:25

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Vilanterol Trifenatate Properties

Melting point	131.9-134.2℃
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Dichloromethane (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
Stability	Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Vilanterol Trifenatate Chemical Properties,Uses,Production

Chemical Properties

Vilanterol trifenatate is a white powder with a molecular weight of 774.8, and the empirical formula is C24H33Cl2NO5.C20H16O2. It insoluble in water and slightly soluble in methanol, ethanol, acetonitrile and propan-2-ol. It is slightly hygroscopic. It is provided in a micronized form.

Uses

Vilanterol Trifenatate is a long-acting β2 adrenergic receptor Agonist with alonger than 24-hour activity in humans, and is being developed to be used in combination with FF. It is also highly selective for the β2-receptor, with over 1000-fold greater selectivity compared to β1-receptors. It demonstrates prolonged bronchodilation in subjects with asthma and COPD.

Definition

ChEBI: Vilanterol Trifenatate is a triphenylacetate salt obtained by combining vilanterol with one equivalent of triphenylacetic acid. Used in combination with fluticasone furoate for treatment of bronchospasm associated with chronic obstructive pulmonary disease. It has a role as a beta-adrenergic agonist and a bronchodilator agent. It contains a vilanterol(1+).

Preparation

Vilanterol trifenatate is synthesized by incorporation of an oxygen atom at the homobenzylic position of the right-hand side phenyl ring of (R)-salmeterol and has suitable chemical properties for inhaled administration. The combination in fluticasone furoate (FF) and vilanterol trifenatate (VI) in a single inhaler is the first once daily combination available on the market for the treatment of stable COPD.

Dosage

The recommended and maximum dose is one inhalation of vilanterol trifenatate 25 micrograms once daily either morning or evening but at the same time every day.

Mode of action

Vilanterol Trifenatate is a selective long-acting beta2-receptor agonist (also referred to as a LABA). The pharmacologic effects of beta2-adrenoceptor agonist drugs, including vilanterol trifenatate, are at least in part attributable to stimulation of intracellular adenylate cyclase, the enzyme that catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

Vilanterol Trifenatate Preparation Products And Raw materials

Raw materials

4H-1,3-Benzodioxin, 6-[(1R)-2-bromo-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,2-dimethyl- (1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol 2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Vilanterol

Triphenylacetic acid

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Preparation Products

Vilanterol Trifenatate Suppliers

Global( 195)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
AVD pharmaceuticals Pvt Ltd	+919860835260	Pune, India	102	58	Inquiry
MELODY HEALTHCARE PVT LTD	+undefined2228780912	Maharashtra, India	20	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
MSN LABORATORIES PRIVATE LTD	+91 40 30438600	New Delhi, India	230	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Melody Health Care Private Limited	08048372882Ext 446	Maharashtra, India	3	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry

Supplier	Advantage
AVD pharmaceuticals Pvt Ltd	58
MELODY HEALTHCARE PVT LTD	58
Ralington Pharma	58
MSN LABORATORIES PRIVATE LTD	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Melody Health Care Private Limited	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
Pharma Affiliates	58

Vilanterol Trifenatate Spectrum

Vilanterol Trifenatate(503070-58-4)¹HNMR

503070-58-4(Vilanterol Trifenatate)Related Search:

Carbamic acid, N-[2-(2,2-dimethyl-4H-1,3-benzodioxin-5-yl)-2-oxoethyl]-, 1,1-dimethylethyl ester Benzaldehyde, 5-[(1R)-2-[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]-1-hydroxyethyl]-2-hydroxy- Phenylacetyl chloride 1,4-Phenylenediacetic acid Ethylenediaminetetraacetic acid

Vilanterol Vilanterol Impurity 14 Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Vilanterol Impurity 3 Triphenylacetate Vilanterol Impurity 6 Triphenylacetate

5-(2,2-diMethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one Vilanterol Impurity 23 Vilanterol Impurity 7 Triphenylacetate Vilanterol Impurity 25 (1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol

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Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1) GW 642444M GW642444M GW-642444M Vilanterol Trifenatate (API) 4-[(R)-2-[[6-[2-(2,6-Dichlorobenzyloxy)ethoxy]hexyl]amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol triphenylacetate GW642444M; GW 642444M; GW-642444M Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-6-2-(2,6-dichlorophenyl)MethoxyethoxyhexylaMinoMethyl-4-hydroxy-1,3-benzenediMethanol (1 GW642444 (trifenatate) (R)-4-(2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl 2,2,2-triphenylacetate Pharmaceuticals Chemical Vilanterol Trifenatate Powder Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1 GW642444M Trifenate (R)-4-(2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol2,2,2-triphenylacetate Vilanterol TrifenatateQ: What is Vilanterol Trifenatate Q: What is the CAS Number of Vilanterol Trifenatate Q: What is the storage condition of Vilanterol Trifenatate Q: What are the applications of Vilanterol Trifenatate Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1) 503070-58-4 Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1) vilanterol trifenatate Vilanterol Trifenate Vilanterol triphenylacetate VilanterolImpurity8Triphenylacetate 1-(3-(6-((pyridin-3-ylmethyl)amino)-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl)ethan-1-ol 503070-58-4 C44H49Cl2NO7 C24H33Cl2NO5C20H16O2 Intermediate 503070-58-4