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2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid

2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Structure
CAS No.
1239233-87-4
Chemical Name:
2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
Synonyms
Febuxostat-2;Febuxostat Impurity C (DA);Febuxostat Diacid Impurity;2-(3-carboxy-4-isobutoxyphenyl);Febuxostat Dicarboxylic Acid Impurity;2-(3-carboxy-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid;2-(3-carboxy-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid;2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid;2-[3-carboxyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid;5-Thiazolecarboxylic acid, 2-[3-carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-
CBNumber:
CB32695012
Molecular Formula:
C16H17NO5S
Molecular Weight:
335.37
MOL File:
1239233-87-4.mol
Modify Date:
2024/7/10 17:45:06

2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Properties

Melting point 218-222°C
Boiling point 568.9±60.0 °C(Predicted)
Density 1.327±0.06 g/cm3(Predicted)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
pka 1.21±0.37(Predicted)
form Solid
color White to Off-White

2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Chemical Properties,Uses,Production

Uses

2-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid is an impurity of Febuxostat (F229000), an xanthine oxidase/ xanthine dehydrogenase inhibitor used for the treatment of hyperuricemia and chronic gout.

2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Febuxostat Dicarboxylic Acid Impurity 2-(3-carboxy-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Febuxostat Impurity 26 (2-(3-carboxy-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid) Febuxostat Impurity C (DA) 2-[3-carboxyl-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid Febuxostat impurity 6/Febuxostat Dicarboxylic Acid/2-(3-carboxy-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat-2 2-(3-carboxy-4-isobutoxyphenyl) 5-Thiazolecarboxylic acid, 2-[3-carboxy-4-(2-methylpropoxy)phenyl]-4-methyl- 2-(3-carboxy-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat Diacid Impurity 2-[3-carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid Febuxostat Dicarboxylic Acid Impurity 2-[3-Carboxy-4-(2-methylpropoxy)phenyl]-4-methyl-5- thiazolecarboxylic acid 1239233-87-4 Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals ZY