PI-1840
- CAS No.
- 1401223-22-0
- Chemical Name:
- PI-1840
- Synonyms
- PI-1840;CS-2559;PI 1840;PI1840;N-isopropyl-2-(4-propylphenoxy)-N-((3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)methyl)acetamide;N-(1-methylethyl)-2-(4-propylphenoxy)-N-[[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]methyl]-acetamide;Acetamide, N-(1-methylethyl)-2-(4-propylphenoxy)-N-[[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]methyl]-;cell proliferation,Proteasome,Caspase,proteasome substrates,poly ADP ribose polymerase,inhibit,NF-κB,Autophagy,cell cycle,anticancer,PI-1840,Apoptosis,Bcl-2 Family,MG-63 cells,Nuclear factor-kappaB,Inhibitor,U2-OS cells,PARP,PI1840,Nuclear factor-κB
- CBNumber:
- CB32716337
- Molecular Formula:
- C22H26N4O3
- Molecular Weight:
- 394.47
- MOL File:
- 1401223-22-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:06
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P280-P305+P351+P338 |
PI-1840 Chemical Properties,Uses,Production
Uses
PI 1840 is a novel rapidly reversible proteasome inhibitor with antitumor activity.
Enzyme inhibitor
This potent proteasome inhibitor (FW = 394.38 g/mol) selectively targets its chymotrypsin-like activity, or CT-L (IC50 = 27 nM), while showing much weaker action (IC50 values >100 μM) against its Trypsin-Like (T-L) and peptidylglutamyl peptide hydrolyzing, or PGPH activities. Mass spectrometry and equilibrium dialysis show no evidence of covalent linkage of PI-1840 with any proteasomal protein component. In intact cancer cells, PI-1840 inhibits CT-L activity, inducing the accumulation of proteasome substrates p27, Bax and IκB-α, thereby inhibiting survival pathways and viability, and inducing apoptosis. PI=1840 is also >100x more active against the constitutive proteasome, compared to immunoproteasome.
PI-1840 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | China | 2989 | 60 | Inquiry |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | China | 9771 | 58 | Inquiry |
| Shanghai Hao Zhun Biological Technology Co., Ltd. | 15800340161 | CHINA | 6846 | 58 | Inquiry |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4264 | 55 | Inquiry |
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