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Mosapride

Mosapride Structure
CAS No.
112885-41-3
Chemical Name:
Mosapride
Synonyms
Moza;Mosapid;TAK-370;Mosid-MT;MOSAPRIDE;Mosapride reference;Mosapride USP/EP/BP;((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide/mosapride;4-AMINO-5-CHLORO-2-ETHOXY-N-((4-(4-FLUOROBENZYL)-2-MORPHOLINYL)METHYL)BENZAMIDE;4-AMINO-5-CHLORO-2-ETHOXY-N-[4-(4-FLUORO-BENZYL)-MORPHOLIN-2-YLMETHYL]-BENZAMIDE
CBNumber:
CB3273304
Molecular Formula:
C21H25ClFN3O3
Molecular Weight:
421.89
MOL File:
112885-41-3.mol
MSDS File:
SDS
Modify Date:
2023/9/20 16:43:00
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Mosapride Properties

Melting point 151-153°C
Boiling point 549.2±50.0 °C(Predicted)
Density 1.272±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 13.52±0.46(Predicted)
color White to Off-White
CAS DataBase Reference 112885-41-3(CAS DataBase Reference)

Mosapride Chemical Properties,Uses,Production

Description

Mosapride citrate, a new gastroprokinetic benzamide was introduced in Japan as Gasmotin for the relief of gastrointestinal symptoms in patients with chronic gastritis, gastro-oesophageal reflux, dyspepsia and post-surgery use. Mosapride is synthesized by final amidation between the corresponding benzoic acid, itself obtained in 3 steps from methyl 4-acetamido salicylate, and the appropriate 2-aminomethyl-morpholine. Mosapride is a 5-HT4 partial agonist without notable activity for D2, 5-HT1 , 5-HT2, alpha-1 and alpha-2 receptors. In dogs, mosapride was as potent as cisapride to stimulate antral and duodenal motility. In most of species including man, mosapride undergoes extensive cleavage to a N-debenzylated metabolite which retains partial 5-HT4 activity but has potent 5-HT3 antagonist activity.

Chemical Properties

White to Off-White Crystalline Solid

Uses

A selective 5-HT4 receptor agonist. Gastroprokinetic.

Hazard

A poison by ingestion.

Safety Profile

A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx, F-, and Cl-.

Mosapride Preparation Products And Raw materials

Raw materials

2-Ethoxy-4-amino-5-chlorobenzoic acid 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine

Preparation Products

Mosapride citrate

Mosapride Suppliers

Global( 190)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29901 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23556 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 9030 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
Career Henan Chemica Co 58
ANHUI WITOP BIOTECH CO., LTD 58
Shaanxi Dideu Medichem Co. Ltd 58

Mosapride Spectrum

Mosapride(112885-41-3)MSMosapride(112885-41-3)1HNMR

112885-41-3(Mosapride)Related Search:

4-AMINO-5-CHLORO-2-ETHOXY-N-[[4-(4-FLUOROBENZYL)-2-MORPHOLINYL]METHYL]BENZAMIDE CITRATE DIHYDRATE Mosapride Impurity 3 Mosapride Impurity 6 Mosapride Impurity 7 4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide
Mosapride Impurity 8 Mosapride Impurity 2 Mosapride Citric Amide Mosapride N-Oxide Des-4-fluorobenzyl Mosapride-d5
Mosapride Impurity 4 Mosapride Lactose Conjugate Mosapride Impurity 1 5-Amino-4-chloro-2-methylphenol 3-Hydroxyazetidine hydrochloride
2-(4-FLUOROBENZYLAMINO)ETHANOL 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE
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4-AMINO-5-CHLORO-2-ETHOXY-N-[[[4-(4-FLUOROPHENYL)METHYL]-2-MORPHOLINYL]METHYL]-BENZAMIDE ((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide/mosapride 4-Amino-5-Chloro-2-Ethoxy-N-((4-(4-Fluorobenzyl)-2-Morpholinyl)Methyl)Benzamide/Mosapride MOSAPRIDE Mosapride/4-Amino-5-Chloro-2-Ethoxy-N-((4-(4-Fluorobenzyl)-2-Morpholinyl)Methyl)Benzamide Mosapid Mosid-MT Moza BenzaMide,4-aMino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)Methyl]-2-Morpholinyl]Methyl]- 4-AMINO-5-CHLORO-2-ETHOXY-N-((4-(4-FLUOROBENZYL)-2-MORPHOLINYL)METHYL)BENZAMIDE 4-AMINO-5-CHLORO-2-ETHOXY-N-[4-(4-FLUORO-BENZYL)-MORPHOLIN-2-YLMETHYL]-BENZAMIDE Mosapride reference TAK-370 Mosapride USP/EP/BP Mosapride-FreebaseQ: What is Mosapride-Freebase Q: What is the CAS Number of Mosapride-Freebase Q: What is the storage condition of Mosapride-Freebase Q: What are the applications of Mosapride-Freebase 112885-41-3 12885-41-3 112885-41-5 C21H25ClFN3O3 API TAK-370, AS-4370, Gasmotin Pharmaceutical Intermediates Amines Aromatics Agonist Intermediates & Fine Chemicals Pharmaceuticals Agro Products