Mosapride citrate
![Mosapride citrate Structure](CAS/GIF/112885-42-4.gif)
- CAS No.
- 112885-42-4
- Chemical Name:
- Mosapride citrate
- Synonyms
- as4370;Gasmotin;enzamidecitrate;AS-4370 citrate;TAK-370 citrate;MOSAPRIDE CITRATE;Mosapride citrate,>99%;Mosapride Citrate (TAK-370;Mosapride citrate USP/EP/BP;Mosapridecitrate/TAK-370citrate/AS-4370citrate
- CBNumber:
- CB6696030
- Molecular Formula:
- C27H33ClFN3O10
- Molecular Weight:
- 614.02
- MOL File:
- 112885-42-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
Melting point | 143-145° |
---|---|
storage temp. | Inert atmosphere,2-8°C |
solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated) |
form | Solid |
color | White to Off-White |
Stability | Hygroscopic |
CAS DataBase Reference | 112885-42-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H332-H335 | |||||||||
Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
Toxicity | LD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera) | |||||||||
NFPA 704 |
|
Mosapride citrate Chemical Properties,Uses,Production
Description
Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.
Uses
As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.
Biological Activity
5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.
Mosapride citrate Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
Hetero Drugs Limited | 08048372500Ext 439 | Hyderabad, India | 174 | 58 | Inquiry |
Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Eshyasi Pharma Limited | 08068441145Ext 848 | Vadodara, India | 5 | 58 | Inquiry |
Jai Radhe Sales | 0091-79-26431096 | New Delhi, India | 157 | 57 | Inquiry |
Anzen Exports | 91-33-24548159 | Kolkata, India | 164 | 58 | Inquiry |
Supplier | Advantage |
---|---|
Hetero Drugs Limited | 58 |
Clearsynth Labs | 58 |
Hetero Drugs Limited | 58 |
Medilink Pharmachem | 50 |
CLEARSYNTH LABS LTD. | 58 |
A.J Chemicals | 58 |
Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
Eshyasi Pharma Limited | 58 |
Jai Radhe Sales | 57 |
Anzen Exports | 58 |
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