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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Neuronal Signaling >5-HT Receptor agonists >Mosapride citrate

Mosapride citrate

Mosapride citrate Structure
CAS No.
112885-42-4
Chemical Name:
Mosapride citrate
Synonyms
as4370;Gasmotin;enzamidecitrate;AS-4370 citrate;TAK-370 citrate;MOSAPRIDE CITRATE;Mosapride citrate,>99%;Mosapride Citrate (TAK-370;Mosapride citrate USP/EP/BP;Mosapridecitrate/TAK-370citrate/AS-4370citrate
CBNumber:
CB6696030
Molecular Formula:
C27H33ClFN3O10
Molecular Weight:
614.02
MOL File:
112885-42-4.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
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Mosapride citrate Properties

Melting point 143-145°
storage temp. Inert atmosphere,2-8°C
solubility DMSO (Slightly), Ethanol (Slightly, Sonicated)
form Solid
color White to Off-White
Stability Hygroscopic
CAS DataBase Reference 112885-42-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
Toxicity LD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera)
NFPA 704
0
3 0

Mosapride citrate Chemical Properties,Uses,Production

Description

Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.

Uses

As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.

Biological Activity

5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.

Mosapride citrate Preparation Products And Raw materials

Raw materials

Mosapride Citric acid

Preparation Products

Mosapride citrate Suppliers

Global( 282)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Hetero Drugs Limited +91-4023704923 +91-4023704923 Telangana, India 296 58 Inquiry
Clearsynth Labs 91-22-45045900 Maharashtra, India 3889 58 Inquiry
Hetero Drugs Limited 08048372500Ext 439 Hyderabad, India 174 58 Inquiry
Medilink Pharmachem +91 (79) 3007-0133 New Delhi, India 424 50 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Eshyasi Pharma Limited 08068441145Ext 848 Vadodara, India 5 58 Inquiry
Jai Radhe Sales 0091-79-26431096 New Delhi, India 157 57 Inquiry
Anzen Exports 91-33-24548159 Kolkata, India 164 58 Inquiry
Supplier Advantage
Hetero Drugs Limited 58
Clearsynth Labs 58
Hetero Drugs Limited 58
Medilink Pharmachem 50
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Eshyasi Pharma Limited 58
Jai Radhe Sales 57
Anzen Exports 58

Mosapride citrate Spectrum

Mosapride citrate(112885-42-4)1HNMR

112885-42-4(Mosapride citrate)Related Search:

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Mosapride Impurity 4 Mosapride Lactose Conjugate Mosapride Impurity 1 Morpholin-2-yl-methylamine 2-Methylmorpholine
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4-AMINO-5-CHLORO-2-ETHOXY-N-[[4-(4-FLUOROBENZYL)-2-MORPHOLINYL]METHYL]BENZAMIDE CITRATE DIHYDRATE 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide 2-hydroxy-1,2,3-propanetricarboxylate Gasmotin enzamidecitrate yl)methyl)-,2-hydroxy-1,2,3-propanetricarboxylate(1:1) 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamidecitrate 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide 4-azanyl-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide Benzamide, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-, 2-hydroxy-1,2,3-propanetricarboxylate 4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate MOSAPRIDE CITRATE (+-)-4-amino-5-chloro-2-ethoxy-n-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)b as4370 benzamide,4-amino-5-chloro-2-ethoxy-n-((4-((4-fluorophenyl)methyl)-2-morpholin AS-4370 citrate TAK-370 citrate Mosapride citrate,>99% Mosapride citrate USP/EP/BP Mosapride Citrate DISCONTINUED PLEASE SEE M730995 Mosapride Citrate (TAK-370 Mosapride CitrateQ: What is Mosapride Citrate Q: What is the CAS Number of Mosapride Citrate Q: What is the storage condition of Mosapride Citrate Q: What are the applications of Mosapride Citrate Mosapridecitrate/TAK-370citrate/AS-4370citrate 112885-42-4 C21H25ClFN3O3C6H8O7C C21H25ClFN3O3C6H8O72H20 C21H25ClFN3O3C6H8O72H2O C21H25ClFN3O3C6H8O7 C21H25ClFN3O3C6H8O7C27H33ClFN3O10 C27H33ClFN3O10 Inhibitors APIS API TAK-370, AS-4370, Gasmotin Gastroprokinetic Agent