ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Imide, amidine >3-Hydroxyazetidine hydrochloride

3-Hydroxyazetidine hydrochloride

CAS No.: 18621-18-6

Chemical Name:: 3-Hydroxyazetidine hydrochloride

Synonyms: AZETIDIN-3-OL HYDROCHLORIDE;3-AZETIDINOL HYDROCHLORIDE;3-HYDROXYAZETIDINE HCL;Azetidin-3-ol hydrochloride, 3-Hydroxyazetane hydrochloride;AZETAN-2-ONE;BUTTPARK 75\04-67;Azetidine-3-ol.Hcl;Baricitinib-009-HCl;3-hydroxyazatidine HCl;3-Hydroxyl-azetidine HCl

CBNumber:: CB0455455

Molecular Formula:: C3H8ClNO

Molecular Weight:: 109.55

MOL File:: 18621-18-6.mol

MSDS File:: SDS

Modify Date:: 2025/4/17 18:22:24

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3-Hydroxyazetidine hydrochloride Properties

Melting point	85-90 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	White to Off-White
Water Solubility	Soluble in water, DMSO, methanol.
Sensitive	Hygroscopic
Stability	Hygroscopic
InChI	InChI=1S/C3H7NO.ClH/c5-3-1-4-2-3;/h3-5H,1-2H2;1H
InChIKey	UQUPQEUNHVVNKW-UHFFFAOYSA-N
SMILES	C1(O)CNC1.Cl
CAS DataBase Reference	18621-18-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

Hazard Codes

C,Xi,Xn

Risk Statements

36/37/38-41-37/38-22

Safety Statements

26-36/37/39

RIDADR

UN1759

WGK Germany

Hazard Note

Harmful/Corrosive

HazardClass

IRRITANT

HS Code

29339900

NFPA 704

	1
2		0

3-Hydroxyazetidine hydrochloride price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	680079	3-Hydroxyazetidine hydrochloride 97%	18621-18-6	1G	₹8789.9	2022-06-14	Buy
Sigma-Aldrich(India)	680079	3-Hydroxyazetidine hydrochloride 97%	18621-18-6	5G	₹29898.65	2022-06-14	Buy
TCI Chemicals (India)	H1264	3-Hydroxyazetidine Hydrochloride	18621-18-6	1G	₹5000	2022-05-26	Buy
TCI Chemicals (India)	H1264	3-Hydroxyazetidine Hydrochloride	18621-18-6	5G	₹15800	2022-05-26	Buy

Product number	Packaging	Price	Buy
680079	1G	₹8789.9	Buy
680079	5G	₹29898.65	Buy
H1264	1G	₹5000	Buy
H1264	5G	₹15800	Buy

3-Hydroxyazetidine hydrochloride Chemical Properties,Uses,Production

Description

3-hydroxyazaecyclobutane hydrochloride is an azaecyclobutane compound that is an important intermediate in the synthesis of Brectinib, which is obtained through a multi-step reaction. Brectinib was approved by the European Union. The monotherapy or in combination with methotrexate for the treatment of adult patients with moderate to severe active rheumatoid arthritis with inadequate or intolerant relief from one or more antirheumatic drugs. It is also the first JAK inhibitor approved in the European Union for the treatment of rheumatoid arthritis.

Chemical Properties

white crystal

Synthesis

A solution of l-(diphenylmethyl)-3-hydroxy azetidine hydrochloride (11.8 g) in absolute ethanol (700 mL) was hydrogenated at room temperature over Pd(OH)2/C in a Parr shaker (4 atm). After 12 hr the catalyst was filtered off and the filtrate evaporated to dryness to give3-hydroxyazetidine hydrochloride (4.20 g, 94%).

3-Hydroxyazetidine hydrochloride Preparation Products And Raw materials

Raw materials

Ethanol Palladium Ethyl acetate Benzhydrylamine Hydrochloric acid

Methanol Epichlorohydrin Isopropyl alcohol Sodium carbonate 1-Azetidinecarboxylic acid, 2-hydroxy-, 1,1-dimethylethyl ester

1-benzylazetidin-3-ol hydrochloride 3-Azetidinol, 1-acetyl-, acetate (ester) (9CI) 1-benzhydrylazetidin-3-Ol 1-tert-Butylazetidin-3-ol 1-Benzylazetidin-3-ol

1-Azabicyclo[1.1.0]butane 1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride

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Preparation Products

1-N-Boc-3-hydroxyazetidine 1-Boc-3-(Amino)azetidine ABT-492

3-Hydroxyazetidine hydrochloride Suppliers

Global( 542)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
BTC pharm India	+918790379245	AndhraPradesh, India	1262	58	Inquiry
GLR Innovations	+91 9891111994	New Delhi, India	4535	58	Inquiry
sales@alchemecopharma.com	+91-91777666469 +91-7799666469	Telangana, India	83	58	Inquiry
Sam Research Labs	+91 9873930190	Hyderabad, India	219	58	Inquiry
Avra Laboratories Pvt Ltd	+91-8008572391 +91-8008572391	Hyderabad, India	43	58	Inquiry
RVR Labs Pvt Ltd	+91-9912882943 +91-9912882943	Hyderabad, India	53	58	Inquiry
Aventus Labs	+91-7021872517 +91-9324342304	Maharashtra, India	168	58	Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd.	+91-26463395 +91-7926462688	Gujarat, India	1615	58	Inquiry
ALS INDIA LIFE SCIENCES	+91-8977036379 +91-8977036379	Hyderabad, India	1878	58	Inquiry
JSK Chemicals	+919879767970	Gujarat, India	3756	58	Inquiry

Supplier	Advantage
BTC pharm India	58
GLR Innovations	58
sales@alchemecopharma.com	58
Sam Research Labs	58
Avra Laboratories Pvt Ltd	58
RVR Labs Pvt Ltd	58
Aventus Labs	58
Rivashaa Agrotech Biopharma Pvt. Ltd.	58
ALS INDIA LIFE SCIENCES	58
JSK Chemicals	58

3-Hydroxyazetidine hydrochloride Spectrum

3-Hydroxyazetidine hydrochloride(18621-18-6)¹HNMR 3-Hydroxyazetidine hydrochloride(18621-18-6)FT-IR

18621-18-6(3-Hydroxyazetidine hydrochloride)Related Search:

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Mosapride citrate 1-(DIPHENYLMETHYL)-3-HYDROXYAZETIDINE HYDROCHLORIDE 3-AZETIDINOL 3-Methoxyazetidine hydrochloride 3-PROPOXY-AZETIDINE HYDROCHLORIDE

1-(Diphenylmethyl)-3-methyl-3-azetidinol hydrochloride 3-ETHOXY-AZETIDINE HYDROCHLORIDE 3-ISOPROPOXY-AZETIDINE HYDROCHLORIDE

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3-HYDROXYAZETIDINE HYDROCHLORIDE BUTTPARK 75\04-67 AZETIDIN-3-OL, HYDROCHLORIDE SALT AZETAN-2-ONE 3-hydroxyazatidine HCl 3-Hydroxyazetidine hydroc... 3-hydroxy-1-azetidine hydrochloride 3-Hydroxyazetidine Hydrochloride, 95+% 3 - hydroxy nitrogen heterocyclic butadiene hydrochloride 3-Azetidinol, hydrochloride (1:1) -Hydroxyazetidine hydrochloride 3-Hydroxyazetidine Hcl Salt 3-hydroxyazacyclobutane hydrochloride 3-HydroxyazetidineHydrochloride> 3-Hydroxyazetidine HydrochL Baricitinib-009-HCl Azetidine-3-ol.Hcl 3-Hydroxyl-azetidine HCl 3-AZETIDINOL HYDROCHLORIDE 3-HYDROXYAZETIDINE HCL AZETIDIN-3-OL HYDROCHLORIDE Azetidin-3-ol hydrochloride, 3-Hydroxyazetane hydrochloride Baricitinib Impurity 2 HCl Baricitinib Impurity 11 HCl 3-Hydroxyazetidine hydrochloride, 98% 18621-18-6 8621-18-6 C3H7ClNO C3H8NOCl C3H7NOHCl C3H7NOClH Azetidines Amino Acids & Derivatives Heterocyclic Building Blocks N-Containing Others B-Amino Amino Acids 13C, 2H, 15N pharmacetical Azetidine Alcohols and Derivatives Heterocycles