Benzhydrylamine
- CAS No.
- 91-00-9
- Chemical Name:
- Benzhydrylamine
- Synonyms
- BENZHYDRYLAMINE;1,1-Diphenylmethanamine;NSC 49127;AURORA KA-7667;Benzhydralamine;Benzyldrylamine;benzohydrylamine;Benzylhydrylamine;a-Phenylbenzylamine;diphenylMethylaMino
- CBNumber:
- CB7409604
- Molecular Formula:
- C13H13N
- Molecular Weight:
- 183.25
- MOL File:
- 91-00-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/18 13:26:42
| Melting point | 12 °C (lit.) |
|---|---|
| Boiling point | 295 °C (lit.) |
| Density | 1.063 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform, DMSO, Methanol |
| form | Liquid |
| pka | 8.41±0.10(Predicted) |
| Specific Gravity | 1.063 |
| color | Clear colorless to yellow |
| Water Solubility | Miscible with chloroform, dimethylsulfoxide and methanol. Slightly miscible with water. |
| Sensitive | Air Sensitive |
| Merck | 14,1076 |
| BRN | 776434 |
| CAS DataBase Reference | 91-00-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Aminodiphenylmethane(91-00-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 2810 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DA4407300 | |||||||||
| F | 9-23 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214990 | |||||||||
| NFPA 704 |
|
Benzhydrylamine price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A53605 | Benzhydrylamine 97% | 91-00-9 | 5G | ₹2478.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A53605 | Benzhydrylamine 97% | 91-00-9 | 25G | ₹5488.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A53605 | Benzhydrylamine 97% | 91-00-9 | 100G | ₹14906.03 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B0124 | Benzhydrylamine min. 97.0 % | 91-00-9 | 25ML | ₹4700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B0124 | Benzhydrylamine min. 97.0 % | 91-00-9 | 100ML | ₹12100 | 2022-05-26 | Buy |
Benzhydrylamine Chemical Properties,Uses,Production
Chemical Properties
Colorless liquid
Uses
Benzhydrylamine is fine-chemical intermediate used for chiral resolution. It acts as an active pharmaceutical ingredient intermediate. It is also employed as a building block for chemical synthesis. Further, it is used in the preparation of furan-2-carboxylic acid benzhydrylamide by reacting with furan-2-carbonyl chloride.
Synthesis
1) synthesis of diphenylketoxime
After benzophenone 10g, oxammonium hydrochloride 6g, 95% ethanol 20mL are put into reaction flask stirring and dissolving, gradation adds sodium hydrate solid 11g.Finish, reaction solution is heated to 88 DEG C of reaction 2h, then pours in dilute hydrochloric acid solution by reaction solution, occurs white solid, filter to obtain diphenylketoxime 10.7g, yield 99%.
2) synthesis of benzhydrylamine
Diphenylketoxime 0.25g, 95% ethanol 5mL are put into reaction flask, after solution change is clear, adds concentration into 5 × 10 7cFU/mL waxy Bacillus solution 50mL, constant temperature 30 DEG C (rotating speed 200r/min) oscillatory reaction in shaking table.TLC detect without raw material time, add appropriate diatomite in reaction solution and carry out centrifugation, get supernatant liquid acidifying, with dichloromethane extraction, aqueous layer basified and with dichloromethane extraction concentrate to obtain benzhydrylamine 9.0g, yield 91%.
Purification Methods
Crystallise the amine from H2O. The free base absorbs CO2 from the atmosphere; store it accordingly. The hydrochloride M 219.7 m 293-295o, crystallises from H2O. [Beilstein 12 H 1323, 12 IV 3282.]
Benzhydrylamine Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Sarex Overseas | +91-9920438667 +91-9920438667 | Mumbai, India | 57 | 58 | Inquiry |
| Allchem Lifescience Pvt. Ltd | +919867655500 | Gujarat, India | 971 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| Cyclo Pharma Chem | +91-9879685500 +91-9879685500 | Gujarat, India | 9 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1879 | 58 | Inquiry |
| Sintilla Medcoms Pvt Ltd | +91-4027808001 +91-8886733867 | Telangana, India | 307 | 58 | Inquiry |
| BTC pharm India | +918790379245 | Telangana, India | 145 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| GLR Innovations | 58 |
| Sarex Overseas | 58 |
| Allchem Lifescience Pvt. Ltd | 58 |
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| Cyclo Pharma Chem | 58 |
| JSK Chemicals | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
| Sintilla Medcoms Pvt Ltd | 58 |
| BTC pharm India | 58 |