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DIHYDROMETHYSTICIN
- CAS No.
- 19902-91-1
- Chemical Name:
- DIHYDROMETHYSTICIN
- Synonyms
- dhm;Nsc112159;PseudoMethysticin;DIHYDROMETHYSTICIN;DIHYDROMETHYLSTICIN;7,8-dihydromethysticin;7,8-DIHYDROMETHYLSTICIN;Methysticin, 7,8-dihydro-;Dihydroanesthetic capsicin;Dihydromethysticin ((+)-Dihydromethysticin)
- CBNumber:
- CB3307966
- Molecular Formula:
- C15H16O5
- Molecular Weight:
- 276.28
- MOL File:
- 19902-91-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:06
| storage temp. | 2-8°C |
|---|---|
| solubility | Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly) |
| Boiling point | 476.1±45.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| Melting point | 117-118 °C |
| form | Solid |
| color | White to Off-White |
| BRN | 91699 |
| Stability | Hygroscopic |
| InChIKey | RSIWXFIBHXYNFM-NSHDSACASA-N |
| LogP | 1.810 (est) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
DIHYDROMETHYSTICIN Chemical Properties,Uses,Production
Description
Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties. Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM. Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice. It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.
DIHYDROMETHYSTICIN Preparation Products And Raw materials
Global( 128)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Chengdu Greenpure Biopharma CO.,Ltd | +8618283602253 | China | 952 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3424 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9626 | 58 | Inquiry |
| Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213302 +8618374838656 | China | 1025 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | China | 18446 | 58 | Inquiry |
19902-91-1(DIHYDROMETHYSTICIN)Related Search:
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6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-2h-pyran-2-on(s)
6-dihydro-4-methoxy-6-(3,4-(methylenedioxy)phenethyl)-(s)-2h-pyran-2-on
7,8-dihydromethysticin
dhm
DIHYDROMETHYLSTICIN
7,8-DIHYDROMETHYLSTICIN
5,6-Dihydro-4-methoxy-6-[2-(1,3-benzodioxol-5-yl)ethyl]-2H-pyran-2-one
6-[2-(1,3-Benzodioxol-5-yl)ethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one
2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[3,4-(methylenedioxy)phenethyl]-, (S)-
2H-Pyran-2-one, 6-[2-(1,3-benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-, (S)-
Methysticin, 7,8-dihydro-
Nsc112159
PseudoMethysticin
(6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-Methoxy-2H-pyran-2-one
DIHYDROMETHYSTICIN
Dihydromethysticin ((+)-Dihydromethysticin)
2H-Pyran-2-one, 6-[2-(1,3-benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-, (6S)-
Dihydromethysticin,Inhibitor,inhibit,CYPs,Cytochrome P450
(S)-6-(2-(Benzo[d][1,3]dioxol-5-yl)ethyl)-4-methoxy-5,6-dihydro-2H-pyran-2-one
Dihydroanesthetic capsicin
19902-91-1
Coumarins