Dihydrokawain
- CAS No.
- 587-63-3
- Chemical Name:
- Dihydrokawain
- Synonyms
- MARINDININ;DIHYDROKAVAIN;DIHYDROKAWAIN;dihydro-kawai;DIHYDROKAWAIN;DIHYDROKAVAIN(P);7,8-Dihydrokavain;7,8-DIHYDROKAWAIN;(S)-(+)-7,8-Dihydrokavain;Dihydrokavain (7,8-Dihydrokawain
- CBNumber:
- CB4314738
- Molecular Formula:
- C14H16O3
- Molecular Weight:
- 232.27
- MOL File:
- 587-63-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:08
Melting point | 58-60° |
---|---|
alpha | D24 +31° (methanol) |
Boiling point | 314.44°C (rough estimate) |
Density | 1.1649 (rough estimate) |
refractive index | 1.5557 (estimate) |
storage temp. | 2-8°C |
solubility |
DMF:25.0(Max Conc. mg/mL);107.62(Max Conc. mM) DMSO:25.0(Max Conc. mg/mL);107.62(Max Conc. mM) Ethanol:5.0(Max Conc. mg/mL);21.52(Max Conc. mM) |
form | Solid |
color | White to off-white |
optical activity | [α]/D 29±2°, c = 0.5 in methanol |
BRN | 15362 |
InChIKey | VOOYTQRREPYRIW-LBPRGKRZSA-N |
LogP | 1.950 (est) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312+P330-P501 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
Dihydrokawain Chemical Properties,Uses,Production
Chemical Properties
White-pale yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the rhizome of kava-kava (Piper methysticum G. Forst).
Uses
(+)-(S)-Dihydrokavain is a kavalactone found in kava beverages consumed by South Pacific islanders. Furthermore, roots and extracts of the kava plant have been used in herbal medicine to treat sleep disturbances, as well as stress and anxiety.
Definition
ChEBI: Dihydrokavain is a member of 2-pyranones and an aromatic ether.
Application
Dihydrokavain is one of the six major kavalactones found in the kava plant; appears to contribute significantly to the anxiolytic effects of kava, based on a study in chicks.Used in herbal medicine to treat sleep disturbances, as well as stress and anxiety.
Preparation
Starting from 2,3-O-isopropylidene-D-glyceraldehyde (2) as chiral material, the naturally occurring (S)-(+)-dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)-(+)-dihydrokavain (1a) is demonstrated for the first time by total synthesis from a chiral source. Its opposite enantiomer, (R)-(–)-dihydrokavain (1b), was also synthesized after inversion of the chiral center in a Mitsunobu reaction.
A Total Synthesis of (+)- and (–)-Dihydrokavain with a Sonochemical Blaise Reaction as the Key Step
Dihydrokawain Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | China | 953 | 58 | Inquiry |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | China | 2931 | 58 | Inquiry |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3772 | 58 | Inquiry |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49403 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29821 | 58 | Inquiry |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | China | 4088 | 58 | Inquiry |
Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
587-63-3(Dihydrokawain)Related Search:
1of4
chevron_right