Chenodeoxycholic acid
- CAS No.
- 474-25-9
- Chemical Name:
- Chenodeoxycholic acid
- Synonyms
- CDCA;CHENODIOL;CHENODEOXYCHOLATE;3ALPHA,7ALPHA-DIHYDROXY-5BETA-CHOLANIC ACID;Chenix;ChenodeoxychoL;3a,7a-Dihydroxy-5b-cholanoic acid;Fluibil;Kebilis;chendol
- CBNumber:
- CB4285737
- Molecular Formula:
- C24H40O4
- Molecular Weight:
- 392.57
- MOL File:
- 474-25-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/2 18:12:07
| Melting point | 165-167 °C (lit.) |
|---|---|
| Boiling point | 437.26°C (rough estimate) |
| alpha | 12 º (c=1, CHCl3) |
| Density | 0.9985 (rough estimate) |
| refractive index | 1.4460 (estimate) |
| Flash point | 9℃ |
| storage temp. | room temp |
| solubility | PRACTICALLY INSOLUBLE |
| form | Powder |
| pka | pKa 4.34 (Uncertain) |
| color | White to off-white |
| Water Solubility | PRACTICALLY INSOLUBLE |
| Merck | 13,2062 |
| BRN | 3219887 |
| InChIKey | RUDATBOHQWOJDD-BSWAIDMHSA-N |
| LogP | 3.05 at 20℃ |
| CAS DataBase Reference | 474-25-9(CAS DataBase Reference) |
| EPA Substance Registry System | Chenodiol (474-25-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 63 | |||||||||
| Safety Statements | 22-24/25-45-36/37 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | FZ1980000 | |||||||||
| HS Code | 29181990 | |||||||||
| NFPA 704 |
|
Chenodeoxycholic acid price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C9377 | Chenodeoxycholic acid | 474-25-9 | 5G | ₹18976.23 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C0750 | Chenodeoxycholic Acid min. 97.0 % | 474-25-9 | 5G | ₹4400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C0750 | Chenodeoxycholic Acid min. 97.0 % | 474-25-9 | 25G | ₹11800 | 2022-05-26 | Buy |
| ottokemi | C 1903 | Chenodeoxycholic acid 98% | 474-25-9 | 100mg | ₹2205 | 2022-05-26 | Buy |
| ottokemi | C 1903 | Chenodeoxycholic acid 98% | 474-25-9 | 500mg | ₹4095 | 2022-05-26 | Buy |
Chenodeoxycholic acid Chemical Properties,Uses,Production
Description
Chenodeoxycholic acid is the first agent to be introduced into the US market for the treatment of radiolucent gallstones. Large scale clinical trials have demonstrated the safety and efficacy of this agent. Chenodeoxycholic acid reduces the biliary concentration of cholesterol relative to that of bile acids and phospholipid, reducing the saturation and thus the lithogenicity of the bile. Success rates in dissolving gallstones are in the range of 50-70% within 4-24 months of treatment. Continuation of the drug after stone dissolution may be required to prevent reoccurrence. Chenodeoxycholic acid is the 7α-isomer of ursodeoxycholic acid which was introduced into the European market in 1978.
chenodeoxycholic acid structure
Chemical Properties
Off-White Solid
History
Chenodeoxycholic acid was isolated in 1924 from goose gall by Adolf Windaus and human gall by Heinrich Wieland.Its complete structural configuation was elucidated by Hans Lettre at the University of Gottingen.
In 1968, William Admirand and Donald Small at Boston University Medical School established that in patients with gallstones their bile was saturated with cholesterol, sometimes even exhibiting microcrystals, whereas this was not the case in normal people.It was then found that biliary levels of cholic acid and chenodeoxycholic acid were lower in patients with cholesterol gallstones than in normal people. Leslie Thistle and John Schoenfield at the Mayo Clinic in Rochester, Minnesota, then administered individual bile salts by mouth for four months and found that chenodeoxycholic acid reduced the amount of cholesterol in the bile.This led to a national collaborative study in the United States, which confirmed the effectiveness of chenodeoxycholic acid in bringing about dissolution of gallstones in selected patients. However, recent developments such as laparoscopic cholecystectomy and endoscopic biliary techniques have curtailed the role of chenodeoxycholic acid and ursodeoxycholic acid in the treatment of cholelithiasis.
Uses
A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus fa cilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol.
World Health Organization (WHO)
Chenodeoxycholic acid was introduced in 1975 for the treatment of cholelithiasis. It is available in several countries and the World Health Organization is not aware that registration has been refused in any other country.
General Description
Chenodeoxycholic acid is a bile acid synthesized in the liver from cholesterol.
Purification Methods
This major bile acid in vertebrates (~80mg) is chromatographed on silica gel (5g) and eluted with CHCl3/EtOAc (3:2) and crystallised from EtOAc/hexane. It has IR: max 1705 cm-1(CHCl3). It also crystallises from EtOAc, EtOAc/heptane after purifying via the poorly soluble Na and K salt if necessary. [Kametani et al. J Org Chem 4 7 2331 1982, Beilstein 10 IV 1604.]
Chenodeoxycholic acid Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SynThink RESEARCH CHEMICALS | +91-8177860948 +91-8177860948 | Mumbai, India | 494 | 58 | Inquiry |
| Arch Pharmalabs Ltd | +91-2242871210 +91-2242871210 | Maharashtra, India | 51 | 58 | Inquiry |
| Medec Dragon Private Limited | +91-9768474716 | Maharashtra, India | 59 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SynThink RESEARCH CHEMICALS | 58 |
| Arch Pharmalabs Ltd | 58 |
| Medec Dragon Private Limited | 58 |
| Clearsynth Labs | 58 |
| CHEMSWORTH | 30 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
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