Ursodeoxycholic acid
- CAS No.
- 128-13-2
- Chemical Name:
- Ursodeoxycholic acid
- Synonyms
- UDCA;URSODIOL;URSODESOXYCHOLIC ACID;Ursodeoxycholic;URSODEOXYCHOLATE;3-alpha,7-beta-dihydroxy-5-beta-cholanoicacid;Tauroursodiol;Urosodeoxycholic Acid;actigall;3-alpha,7-beta-dihydroxy-5-beta-cholan-24-oicaci
- CBNumber:
- CB1285736
- Molecular Formula:
- C24H40O4
- Molecular Weight:
- 392.57
- MOL File:
- 128-13-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/2 18:12:07
| Melting point | 203-204 °C (lit.) |
|---|---|
| Boiling point | 437.26°C (rough estimate) |
| alpha | 60 º (c=2, EtOH) |
| Density | 0.9985 (rough estimate) |
| refractive index | 60.5 ° (C=2, EtOH) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | ethanol: 50 mg/mL, clear |
| pka | pKa 5.04±0.04(H2O t = 25.0±0.1 I = 0.00)(Approximate) |
| form | Solid. Powder. |
| color | White - almost white. |
| Water Solubility | practically insoluble |
| Merck | 14,9889 |
| BRN | 3219888 |
| InChIKey | RUDATBOHQWOJDD-UZVSRGJWSA-N |
| LogP | 3-3.38 at 20℃ |
| CAS DataBase Reference | 128-13-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | FZ2000000 | |||||||||
| F | 10 | |||||||||
| HS Code | 29181990 | |||||||||
| Toxicity | LD50 in mice (g/kg): 0.1 i.v. (Ardenne, Reitnauer); in rats, mice (mg/kg): 2000, 6000 s.c.; 1000, 1200 i.p., 310, 260 i.v. (Ward) | |||||||||
| NFPA 704 |
|
Ursodeoxycholic acid price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1579 | Ursodiol Pharmaceutical Secondary Standard; Certified Reference Material | 128-13-2 | 500MG | ₹9103.83 | 2022-06-14 | Buy |
| ALFA India | ALF-B20490-14 | Ursodeoxycholic acid, 99% | 128-13-2 | 25g | ₹20682 | 2022-05-26 | Buy |
| ALFA India | ALF-B20490-06 | Ursodeoxycholic acid, 99% | 128-13-2 | 5g | ₹5412 | 2022-05-26 | Buy |
| ALFA India | ALF-B20490-03 | Ursodeoxycholic acid, 99% | 128-13-2 | 1g | ₹3881 | 2022-05-26 | Buy |
| TCI Chemicals (India) | U0030 | Ursodeoxycholic Acid | 128-13-2 | 5G | ₹5600 | 2022-05-26 | Buy |
Ursodeoxycholic acid Chemical Properties,Uses,Production
Chemical Properties
WHITE CRYSTALLINE POWDER
Uses
Ursodeoxycholic acid (UDCS) is a cell protectant used extensively to mitigate hepatic and biliary diseases. Ursodeoxycholic acid may be used to study its specific activities that range from reduction of cholesterol absorpition, cholesterol gallstone dissolution to suppression of immune response. It is also used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7.
Definition
ChEBI: Ursodeoxycholic acid is a bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones. It has a role as a human metabolite and a mouse metabolite. It is a bile acid, a dihydroxy-5beta-cholanic acid and a C24-steroid. It is a conjugate acid of an ursodeoxycholate.
General Description
Ursodeoxycholic acid (UDCA) is a secondary bile acid that helps regulate cholesterol. Mass spectrometry-based analysis of UDCA is routinely performed in clinical diagnostic testing applications such as neonatal testing of inborn errors of bile acid synthesis, differentiating among types of familial intrahepatic cholestasis, and therapeutic monitoring of patient responses to UDCA therapy. This Certified Spiking Solution? is suitable as a starting material in preparation of linearity standards, calibrators, and controls for use in LC-MS/MS and GC/MS bile acid testing methods.
Purification Methods
Recrystallise ursodiol from wet Et2O, EtOH or EtOH/MeOH. [Iwasaki Hoppe Seyler's Z Physiol Chem 244 181, 183 1936, Beilstein 10 III 1635.]
Ursodeoxycholic acid Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Sonia Organics | +91-9538454135 +91-9538454135 | Karnataka, India | 28 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 404 | 58 | Inquiry |
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| AARTIA KEM SCIENCE | +91-8291072530 +91-8291072530 | Maharashtra, India | 70 | 58 | Inquiry |
| Honour Lab Limited | +919845977466 | Telangana, India | 164 | 58 | Inquiry |
| Shilpa Medicare Limited (SML) | +91-8532238704 +91-9320649838 | Karnataka, India | 61 | 58 | Inquiry |
| Glenmark Pharmaceuticals Limited | +912240189999 | Maharashtra, India | 93 | 58 | Inquiry |
| IOL Chemicals And Pharmaceuticals Limited | +91-9878429978 +91-9878996045 | Punjab, India | 30 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| Sonia Organics | 58 |
| SNECOFRi Pvt Ltd | 58 |
| Medi Pharma Drug House | 58 |
| AARTIA KEM SCIENCE | 58 |
| Honour Lab Limited | 58 |
| Shilpa Medicare Limited (SML) | 58 |
| Glenmark Pharmaceuticals Limited | 58 |
| IOL Chemicals And Pharmaceuticals Limited | 58 |
| Ralington Pharma | 58 |
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