22(R)-HYDROXYCHOLESTEROL

CAS No.: 17954-98-2

Chemical Name:: 22(R)-HYDROXYCHOLESTEROL

Synonyms: 22R-OHC;22(R)-OH-CH;Narthesterol;22α-hydroxycholesterol;22BF-HYDROXYCHOLESTEROL;Cholesterol 22α-Hydroxy;22α-Hydroxy Cholesterol;22(R)-Hydroxycholestero;Chlorambucil Impurity 8;22(R)-HYDROXYCHOLESTEROL

CBNumber:: CB3350290

Molecular Formula:: C27H46O2

Molecular Weight:: 402.65

MOL File:: 17954-98-2.mol

MSDS File:: SDS

Modify Date:: 2023/5/18 11:31:14

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22(R)-HYDROXYCHOLESTEROL Properties

Melting point	171-174°C
Boiling point	513.1±23.0 °C(Predicted)
Density	1.03±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	15.01±0.20(Predicted)
color	White to Off-White
InChIKey	RZPAXNJLEKLXNO-QUOSNDFLSA-N

SAFETY

Risk and Safety Statements

WGK Germany	3

22(R)-HYDROXYCHOLESTEROL price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	H9384	22(R)-Hydroxycholesterol ≥98%	17954-98-2	1MG	₹10121.38	2022-06-14	Buy
Sigma-Aldrich(India)	H9384	22(R)-Hydroxycholesterol ≥98%	17954-98-2	5MG	₹33828.13	2022-06-14	Buy

Product number	Packaging	Price	Buy
H9384	1MG	₹10121.38	Buy
H9384	5MG	₹33828.13	Buy

22(R)-HYDROXYCHOLESTEROL Chemical Properties,Uses,Production

Description

The liver X receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols. LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. 22(R)-hydroxy Cholesterol is an endogenous agonist for LXRs that activates LXRα with an EC₅₀ value of 325 nM. 22(R)-hydroxy Cholesterol, acting through LXR heterodimerized with the retinoid X receptor, induces the expression of the ABCA1 reverse cholesterol transporter. This activity increases the efflux of cholesterol from enterocytes and thus inhibits the overall absorption of cholesterol. 22(R)-hydroxy Cholesterol can be used as a substrate to monitor cholesterol transport or as an endogenous positive control for testing LXR agonists which have potential as therapeutic agents for the treatment of atherosclerosis.

Uses

Bovine aortic endothelial cells were treated with 22(R)-Hydroxycholesterol to study the effects on production of free radicals and in studies related to fatty acid metabolism.

Definition

ChEBI: An oxysterol that is the 22R-hydroxy derivative of cholesterol.

General Description

22(R)-hydroxycholesterol is a diastereomer of 22(S)-hydroxycholesterol. It is present in neonate brain.

22(R)-HYDROXYCHOLESTEROL Preparation Products And Raw materials

Raw materials

Preparation Products

22(R)-HYDROXYCHOLESTEROL Suppliers

Global( 65)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	18648	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	China	9425	58	Inquiry
GIHI CHEMICALS CO.,LIMITED	+8618058761490	China	50000	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33350	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry

Supplier	Advantage
Pharma Affiliates	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Henan Aochuang Chemical Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

22(R)-HYDROXYCHOLESTEROL Spectrum

22(R)-HYDROXYCHOLESTEROL(17954-98-2)¹HNMR

17954-98-2(22(R)-HYDROXYCHOLESTEROL)Related Search:

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22(R)-HYDROXYCHOLESTEROL 5-CHOLESTENE 5,20-ALPHA, 22-ALPHA, 25D-SPIROSTEN-3-BETA-OL ACETATE

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22α-Hydroxycholesterol, 5-Cholestene-3β,22(R)-diol, 5-Cholestene-3β,22[R]-diol (22R)-Cholest-5-ene-3β,22-diol 22R-OHC (3beta,22R)-Cholest-5-ene-3,22-diol Cholest-5-ene-3,22-diol, (3beta,22R)- (20S,22R)-Cholest-5-ene-3β,22-diol (3β,22R)-Cholest-5-ene-3,22-diol Cholest-5-ene-3β,22(R)-diol Narthesterol 5-Cholestene-3β,22(R)-diol 5-Cholestene-3β,22[R]-diol 22BETA-HYDROXYCHOLESTEROL 22BF-HYDROXYCHOLESTEROL 22-ALPHA-HYDROXYCHOLESTEROL 22(R)-HYDROXYCHOLESTEROL 22(R)-OH-CH 22-HYDROXYCHOLESTEROL (22R) 3BETA,22BETA-DIHYDROXY-5-CHOLESTENE 5-CHOLESTEN-3-BETA, 22(R)-DIOL 5-CHOLESTENE-3BETA,22[R]-DIOL CHOLEST-5-ENE-3BETA,22R-DIOL 22[R]-Hydroxycholesterol (not deuterated) 22α-hydroxycholesterol (22a-Hydroxycholesterol, 5-Cholestene-322(R)-diol) Cholesterol 22α-Hydroxy 22α-Hydroxy Cholesterol 22(R)-Hydroxycholestero Cholest-5-ene-3,22-diol, (3β,22R)- Chlorambucil Impurity 8 5-CHOLESTEN-3β, 22(R)-DIOL 17954-98-2 Lipids Sterols Cholesterol and Derivatives BioChemical Biochemicals and Reagents Hydroxycholesterol Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Steroids