Formamidine acetate
- CAS No.
- 3473-63-0
- Chemical Name:
- Formamidine acetate
- Synonyms
- FAA;forMiMidaMide acetate;Formamidinium acetate;FORMAMIDINE ACETATE SALT;IMINOFORMAMIDE ACETATE;Methanimidamide(9CI);Methanimidamide monoacetate;FORMAMIDINE ACETIC ACID SALT;ormamidine acetate;FORMAMIDINE ACETATE
- CBNumber:
- CB3408896
- Molecular Formula:
- C3H8N2O2
- Molecular Weight:
- 104.11
- MOL File:
- 3473-63-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/18 8:51:57
| Melting point | 158-161 °C (dec.)(lit.) |
|---|---|
| Density | 1.124 |
| storage temp. | Store below +30°C. |
| solubility | 832g/l |
| form | Liquid |
| color | Clear colorless to light yellow |
| PH | 8 (400g/l, H2O, 20℃) |
| Water Solubility | 832 g/L (21 ºC) |
| Sensitive | Hygroscopic |
| BRN | 3563488 |
| InChI | InChI=1S/C2H4O2.CH4N2/c1-2(3)4;2-1-3/h1H3,(H,3,4);1H,(H3,2,3) |
| InChIKey | XPOLVIIHTDKJRY-UHFFFAOYSA-N |
| SMILES | C(C)(=O)O.C(=N)N |
| CAS DataBase Reference | 3473-63-0(CAS DataBase Reference) |
| EPA Substance Registry System | Methanimidamide, monoacetate (3473-63-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317 | |||||||||
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P362+P364 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 43-36/37/38 | |||||||||
| Safety Statements | 36/37-37/39-26-36/37/39-27 | |||||||||
| WGK Germany | 2 | |||||||||
| F | 3-9-21 | |||||||||
| Autoignition Temperature | 565 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29252000 | |||||||||
| Toxicity | LD50 orally in Rabbit: 2510 mg/kg LD50 dermal Rat > 2000 mg/kg | |||||||||
| NFPA 704 |
|
Formamidine acetate price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F15803 | Formamidine acetate salt 99% | 3473-63-0 | 100G | ₹3518.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F15803 | Formamidine acetate salt 99% | 3473-63-0 | 500G | ₹13314.75 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.14653 | Formamidine acetate for synthesis | 3473-63-0 | 100G | ₹7840 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.14653 | Formamidine acetate for synthesis | 3473-63-0 | 500G | ₹14920 | 2022-06-14 | Buy |
| TCI Chemicals (India) | F0154 | Formamidine Acetate | 3473-63-0 | 25G | ₹1800 | 2022-05-26 | Buy |
Formamidine acetate Chemical Properties,Uses,Production
Description
Formamidine acetate is an anti-tuberculosis drug that belongs to the class of aminoglycosides. It has been shown to have a potent cytotoxic effect on malignant brain cells in vitro. It inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. It also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.
Chemical Properties
white to light yellow crystalline powder
Uses
Formamidine acetate is used as an intermediate in the synthesis of active pharmaceutical ingredients. It is also used as a condensing agent for the preparation of pyrimidine and imidazole heterocycles.
Purification Methods
Unlike the hydrochloride, the acetate salt is not hygroscopic. It is recrystallised from a small volume of acetic acid, by addition of EtOH and the crystals are washed with EtOH then Et2O and dried in a vacuum. [Taylor et al. Org Synth 46 39 1966, Beilstein 2 IV 82.]
Formamidine acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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