THIOLUTIN
- CAS No.
- 87-11-6
- Chemical Name:
- THIOLUTIN
- Synonyms
- T-00098;NSC 3927;THIOLUTIN;Acetopyrrothin;Thiolutin ,80%;acetopyrrothine;THIOLUTIN USP/EP/BP;THIOLUTIN (ACETOPYRROTHIN);Thiolutin, from Streptomyces;Thiolutin NSC 3927
- CBNumber:
- CB3435551
- Molecular Formula:
- C8H8N2O2S2
- Molecular Weight:
- 228.29
- MOL File:
- 87-11-6.mol
- Modify Date:
- 2023/6/8 9:01:59
| Melting point | 273-276℃ |
|---|---|
| Boiling point | 200°C (rough estimate) |
| Density | 1.4614 (rough estimate) |
| refractive index | 1.5690 (estimate) |
| storage temp. | −20°C |
| solubility | DMSO: 5 mg/mL |
| form | Yellow crystalline solid. |
| pka | 10.54±0.20(Predicted) |
| color | Brilliant-yellow needles from 1-butanol |
| Stability | Stable for 3 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| EPA Substance Registry System | Thiolutin (87-11-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T+,T | |||||||||
| Risk Statements | 28 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | JP1355000 | |||||||||
| HS Code | 29419090 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 25 s.c.; 25 orally (Seneca) | |||||||||
| NFPA 704 |
|
THIOLUTIN Chemical Properties,Uses,Production
Description
Thiolutin is a natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases (IC50 = 3 μg/ml). Because of this, it can be used for the analysis of mRNA stability. Thiolutin also inhibits endothelial cell adhesion (IC50 < 1 μM) and S180 tumor-
Chemical Properties
Yellow solid
Uses
Thiolutin is an antibiotic isolated from several strains of Streptomyces albus. Thiolutin is a natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases.
Biological Activity
Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC 50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis.
Safety Profile
Poison by ingestion andsubcutaneous routes. When heated to decomposition itemits very toxic fumes of NOx and SOx.
THIOLUTIN Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 94)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24099 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | China | 25009 | 65 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9268 | 58 | Inquiry |
| InvivoChem | 13549236410 | China | 6755 | 58 | Inquiry |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | China | 5012 | 58 | Inquiry |
87-11-6(THIOLUTIN)Related Search:
acetopyrrothine
6-acetamido-4-methyl-2-dithiolo(4.3-b)pyrrol-5(4h)-one
6-acetamido-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4h)-one
6-(acetylamino)-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4h)-one
N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide
N-(4-methyl-5-oxo-[1,2]dithiolo[4,3-b]pyrrol-6-yl)ethanamide
T-00098
4-Methyl-6-(acetylamino)-4,5-dihydro-1,2-dithiolo[4,3-b]pyrrole-5-one
4-Methyl-6-(acetylamino)-1,2-dithiolo[4,3-b]pyrrole-5(4H)-one
Thiolutin from Streptomyces luteosporeus
Aureothricin, Farcinicin, Propiopyvothine
6-acetamido-4-methyl-1,2-dithiolo[4,3-b]pyrrol-5-one
Thiolutin NSC 3927
NSC 3927
Acetopyrrothin
Thiolutin ,80%
N-(5-keto-4-methyl-dithiolo[4,3-b]pyrrol-6-yl)acetamide
N-acetylpyrrothine, Farcinicine, Acetopyrrothine
N-(4-Methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetaMide
3-acetamido-5-methylpyrrolin-4-one(4,3-d)-1,2-dithiole
N-(4,5-DIHYDRO-4-METHYL-5-OXO-1,2-DITHIOLO[4,3-B]PYRROL-6-YL)ACETAMIDE
THIOLUTIN
THIOLUTIN USP/EP/BP
Thiolutin, from Streptomyces
Acetamide, N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-
THIOLUTIN (ACETOPYRROTHIN)
87-11-6
1987-11-6
C8H8N2S2O2
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