Gentamicin sulfate
- CAS No.
- 1405-41-0
- Chemical Name:
- Gentamicin sulfate
- Synonyms
- GENTAMICIN SULPHATE STERILE;Gentak;U-gencin;GENTAMICIN 2,5-SULFATE HYDRATE;100ppm;Apogen;Pangram;sch9724;Garacin;Gentalin
- CBNumber:
- CB2733991
- Molecular Formula:
- C60H127N15O26S
- Molecular Weight:
- 1506.8
- MOL File:
- 1405-41-0.mol
- Modify Date:
- 2024/5/29 17:48:59
| Melting point | 218-237°C |
|---|---|
| alpha | D25 +102° |
| Density | 1.000 g/cm3 |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL As stock solution, store at −20°C. Stable at 37°C for 5 days. |
| form | powder |
| color | colorless to light yellow |
| PH | 4.0-5.5 (0.1g/mL in H2O) |
| Odor | odorless |
| optical activity | [α]20/D +110±8°, c = 1% in H2O |
| Water Solubility | Soluble in water |
| Merck | 13,4403 |
| InChIKey | RDEIXVOBVLKYNT-HDZPSJEVSA-N |
| CAS DataBase Reference | 1405-41-0(CAS DataBase Reference) |
| EPA Substance Registry System | Gentamicin sulfate (1405-41-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H317-H334 | |||||||||
| Precautionary statements | P261-P272-P280-P284-P302+P352-P333+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 42/43 | |||||||||
| Safety Statements | 23-36/37-45-22-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | LY2625000 | |||||||||
| F | 3 | |||||||||
| HS Code | 29419010 | |||||||||
| Toxicity | LD50 in mice (mg base/kg): 430 i.p.; 485 s.c.; 75 i.v.; >9050 orally (Black) | |||||||||
| NFPA 704 |
|
Gentamicin sulfate price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G3632 | Gentamicin sulfate salt potency: ≥590?I.U. Gentamicin base per mg | 1405-41-0 | 250MG | ₹3572.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G3632 | Gentamicin sulfate salt potency: ≥590?I.U. Gentamicin base per mg | 1405-41-0 | 1G | ₹7696.58 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1077 | Gentamicin Sulfate Pharmaceutical Secondary Standard; Certified Reference Material | 1405-41-0 | 1G | ₹10792.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G3632 | Gentamicin sulfate salt potency: ≥590?I.U. Gentamicin base per mg | 1405-41-0 | 10G | ₹31457.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G4918 | Gentamicin sulfate meets EP, USP testing specifications | 1405-41-0 | 250MG | ₹4384.13 | 2022-06-14 | Buy |
Gentamicin sulfate Chemical Properties,Uses,Production
Chemical Properties
White to buff-colored powder, hygroscopic, easily soluble in water, insoluble in lipids, insoluble in organic solvents, stable in chemical properties, relatively stable to changes in temperature and pH, the pH of 4% aqueous solution is 4.0-6.0. There are five basic centers in the gentamicin molecule, which is a basic compound, and the drug is the sulfate of gentamicin. Gentamicin is a complex of C components, the main components of which are C1, C2, C1a, and C2a.
Uses
Gentamicin sulfate is an aminoglycoside antibiotic. Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antibacterial. Antibiotic complex consists of three closely related components, gentamicins C1, C2, C1a, and also gentamicin A which differs from the other members of the complex but is similar to Kanamycin C. Gentamicin C1: R1=R2=CH3 Gentamicin C2: R1=CH3; R2=H Gentamicin C1A: R1=R2=H.
General Description
Gentamicin sulfate is a sulfate salt of an antibiotic complex produced by fermentation of Micromonospora purpurea or M. echinospora. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base. Three closely related components that are chemically amino-saccharides. White to buff-colored powder. pH (4% solution) 3.5 to 5.5. Odorless.
Air & Water Reactions
Water soluble. Hygroscopic.
Reactivity Profile
Gentamycin sulfate is very stable in solution, even in moderately acidic to strongly basic aqueous media.
Fire Hazard
Flash point data for Gentamycin sulfate are not available; however, Gentamycin sulfate is probably combustible.
Safety Profile
Poison by intravenous, intraperitoneal, and intramuscular routes. Moderately toxic by subcutaneous route. Human systemic effects: level changes for metals other than Na/K/Fe/Ca/P/Cl. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx. See also other gentamycin entries.
References
Schroeder et al (2000) Modulation of RNA function by aminoglycoside antibiotics. EMBO.J. 4 1. PMID: 10619838.
Casemore (1967) Gentamicin as a bactericidal agent in virological tissue cultures. J.Clin.Pathol. 20 298. PMID: 4972293
Martin, N.L., et al. Gentamicin interaction with Pseudomonas aeruginosa cell envelope. J. Comp. Neurol. 1986, 29(6), 1079-1087. DOI:10.1128/AAC.29.6.1079
Kadurugamuwa, J.L., et al. Surface action of gentamicin on Pseudomonas aeruginosa. J. Bacteriol. 1993, 175(18), 5798-805. DOI:10.1128/jb.175.18.5798-5805.1993
Gentamicin sulfate Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Unicorn Pharmachem Private Limited. | 91-22-23483128 | Maharashtra, India | 114 | 58 | Inquiry |
| Vipul Drugs Pvt., Ltd. | 91-22-26101436 | Maharashtra, India | 102 | 58 | Inquiry |
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