DEMECOLCINE
- CAS No.
- 477-30-5
- Chemical Name:
- DEMECOLCINE
- Synonyms
- COLCEMID;COLCHAMINE;(S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one;omain;Osamin;omaine;C-12669;nsc3096;Colcemide;ColchaMin
- CBNumber:
- CB3460085
- Molecular Formula:
- C21H25NO5
- Molecular Weight:
- 371.43
- MOL File:
- 477-30-5.mol
- Modify Date:
- 2024/7/2 8:55:06
| Melting point | 73-75°C |
|---|---|
| alpha | D20 -129.0° (c = 1 in chloroform) |
| Boiling point | 501.11°C (rough estimate) |
| Density | 1.2350 (rough estimate) |
| refractive index | 1.5614 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: 10 mg/mL |
| form | powder |
| pka | 8.48±0.40(Predicted) |
| color | White to off-white |
| Sensitive | Air & Light Sensitive |
| BRN | 2822892 |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P301+P310 | |||||||||
| Hazard Codes | T,T+ | |||||||||
| Risk Statements | 25-26/27/28 | |||||||||
| Safety Statements | 22-24/25-45-36/37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GH0800000 | |||||||||
| F | 8-10-23 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| Toxicity | LD50 oral in mouse: 25530ug/kg | |||||||||
| NFPA 704 |
|
DEMECOLCINE price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D7385 | Demecolcine ≥98% (HPLC) | 477-30-5 | 5MG | ₹18294.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7385 | Demecolcine ≥98% (HPLC) | 477-30-5 | 10MG | ₹31219.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7385 | Demecolcine ≥98% (HPLC) | 477-30-5 | 50MG | ₹101083.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D1925 | Demecolcine solution 10?μg/mL in HBSS, ACF Qualified, BioXtra | 477-30-5 | 20ML | ₹6105.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D1925 | Demecolcine solution 10?μg/mL in HBSS, ACF Qualified, BioXtra | 477-30-5 | 100ML | ₹10294.58 | 2022-06-14 | Buy |
DEMECOLCINE Chemical Properties,Uses,Production
Description
Colcemid is a colchicine derivative that inhibits tubulin polymerization as potently as colchicine (IC50 = 2.1 and 2.4 μM, respectively) but is less toxic. At very low (nanomolar) concentrations, colcemid suppresses microtubule dynamicity and inhibits cell migration, while at micromolar levels it blocks microtubule assembly, arresting cells in metaphase. Mitotic block by colcemid is used to synchronize cells and for karyotyping in cytogenetic studies. Prolonged exposure to colcemid can activate p53, leading to apoptosis.
Chemical Properties
Faintly Yellow Crystalline Powder
Uses
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Definition
ChEBI: A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than olchicine and is used as an antineoplastic.
General Description
Colcemid is also known as demecolcine. Its generic name is N-methyl-N-deacetyl-colchicine. Colcemid depolymerizes microtubules and blocks mitosis at metaphase.
Safety Profile
Poison by ingestion, intraperitoneal, parenteral, intravenous, and intramuscular routes. Human systemic effects by ingestion: (skin and appendages) hair effects. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Colcemide is purified by chromatography on silica and eluting with CHCl3/MeOH (9:1), and by recrystallisation from EtOAc/Et2O to form yellow prisms. UV in EtOH has max 243nm ( 30,200) and 350nm ( 16,3000). [Synthesis, IR, NMR, MS: Capraro & Brossi Helv Chim Acta 62 965 1979, Beilstein 8 IV 3319.]
DEMECOLCINE Preparation Products And Raw materials
DEMECOLCINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20308 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25247 | 58 | Inquiry |