Simvastatin Impurity 39

Simvastatin Impurity 39 Structure
CAS No.
79902-42-4
Chemical Name:
Simvastatin Impurity 39
Synonyms
-EthylSimvastatin;2′-Ethyl Simvastatin;Simvastatin Impurity 2;Simvastatin EP Impurity 9;Simvastatin EP Impurity I;(1S,3R,7S,8S,8aR)-8-(2-((2R,4R);2' Ethyl Simvastatin,2'Ethyl Simvastatin;Simvastatin Impurity 25(Simvastatin EP Impurity I);(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,;(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl isobutyrate
CBNumber:
CB34813300
Molecular Formula:
C23H34O5
Molecular Weight:
390.51
MOL File:
79902-42-4.mol
Modify Date:
2023/4/23 13:52:06

Simvastatin Impurity 39 Properties

Melting point 136 - 138°C
Boiling point 549.0±50.0 °C(Predicted)
Density 1.13±0.1 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Dichloromethane (Slightly), Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 13.49±0.40(Predicted)
color White to Off-White

Simvastatin Impurity 39 Chemical Properties,Uses,Production

Uses

2''-Ethyl Simvastatin is an impurity of Simvastatin (S485000), a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.

Simvastatin Impurity 39 Preparation Products And Raw materials

Raw materials

Preparation Products

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2′-Ethyl Simvastatin (1S,3R,7S,8S,8aR)-8-(2-((2R,4R) Simvastatin EP Impurity I Simvastatin Impurity 25(Simvastatin EP Impurity I) (1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl isobutyrate -EthylSimvastatin (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7, Simvastatin Impurity 2 2' Ethyl Simvastatin,2'Ethyl Simvastatin Propanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester Simvastatin EP Impurity 9 79902-42-4